Patents by Inventor Alfredo C. Castro

Alfredo C. Castro has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Patent number: 7851637
    Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Grant
    Filed: June 17, 2005
    Date of Patent: December 14, 2010
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Wei Deng, Kristopher M. Depew, Michael A. Foley, Christian C. Fritz, Asimina T. Georges Evangelinos, Michael J. Grogan, Nafeeza Hafeez, Edward B. Holson, Brian T. Hopkins, Nii O. Koney, Tao Liu, David A. Mann, Lisa A. Marcaurelle, Daniel A. Snyder, Dennis J. Underwood, Andrew A. Wylie, Lin-Chen Yu, Linping Zhang
  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Patent number: 7842815
    Abstract: One aspect of the present invention relates to heterocyclic compounds that bind to bcl proteins and inhibit Bcl function. Another aspect of the present invention relates to compositions comprising a heterocyclic compound of the invention. The present invention provides methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Grant
    Filed: November 15, 2006
    Date of Patent: November 30, 2010
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Alfredo C. Castro, Edward B. Holson, Brian T. Hopkins, Nii O. Koney, Daniel A. Snyder, Thomas T. Tibbitts
  • METHODS OF USE OF CYCLOPAMINE ANALOGS
    Publication number: 20100286180
    Abstract: The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: December 27, 2007
    Publication date: November 11, 2010
    Applicants: Infinity Pharmaceuticals, Inc., Johns Hopkins University
    Inventors: Alfredo C. Castro, Michael J. Grogan, William Matsui, Karen J. McGovern, Martin Tremblay
  • Cyclopamine analogs
    Patent number: 7812164
    Abstract: The invention provides novel derivatives of cyclopamine having the following formula:
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: October 12, 2010
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Brian Austad, Mark L. Behnke, Alfredo C. Castro, Michael J. Grogan, Somarajannair Janardanannair, Andre Lescarbeau, Stephane Peluso, Martin Tremblay
  • Compounds and Methods for Inhibiting the Interaction of BCL Proteins with Binding Partners
    Publication number: 20100190791
    Abstract: The present invention relates to heterocyclic compounds that bind to Bcl proteins and inhibit Bcl function, compositions comprising such compounds, and methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Application
    Filed: April 2, 2010
    Publication date: July 29, 2010
    Applicant: INFINITY PHARMACEUTICALS, INC.
    Inventors: ALFREDO C. CASTRO, MICHAEL J. GROGAN, EDWARD B. HOLSON, BRIAN T. HOPKINS, NII O. KONEY, STEPHANE PELUSO, DANIEL A. SNYDER
  • Compounds and methods for inhibiting the interaction of BCL proteins with binding partners
    Patent number: 7745464
    Abstract: The present invention relates to heterocyclic compounds that bind to Bcl proteins and inhibit Bcl function, compositions comprising such compounds, and methods for treating and modulating disorders associated with hyperproliferation, such as cancer.
    Type: Grant
    Filed: December 15, 2006
    Date of Patent: June 29, 2010
    Inventors: Alfredo C. Castro, Michael J. Grogan, Edward B. Holson, Brian T. Hopkins, Nii O. Koney, Stephane Peluso, Daniel A. Snyder
  • Heterocyclic Cyclopamine Analogs and Methods of Use Thereof
    Publication number: 20100144775
    Abstract: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Application
    Filed: December 2, 2009
    Publication date: June 10, 2010
    Inventors: Alfredo C. Castro, Michael J. Grogan, Martin Tremblay
  • Heterocyclic cyclopamine analogs and methods of use thereof
    Patent number: 7648994
    Abstract: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Grant
    Filed: March 7, 2008
    Date of Patent: January 19, 2010
    Assignee: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Martin Tremblay
  • CYCLOPAMINE ANALOGS
    Publication number: 20090216022
    Abstract: The invention provides novel derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: August 27, 2008
    Publication date: August 27, 2009
    Inventors: Brian Austad, Mark L. Behnke, Alfredo C. Castro, Andre B. Charette, Michael J. Grogan, Somarajannair Janardanannair, Andre Lescarbeau, Stephane Peluso, Martin Tremblay
  • INHIBITORS OF FATTY ACID AMIDE HYDROLASE
    Publication number: 20090099131
    Abstract: The present invention provide compounds, and pharmaceutical compositions thereof, encompassed by the formulae (I), (II) or (III). The present invention also provides methods for treating an FAAH mediated disease, disorder or condition by administering a therapeutically effective amount of a provided compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof. Additionally, the present invention provides methods for inhibiting FAAH in a patient by administering a therapeutically effective amount of a compound of the formulae (I), (II) or (III), or a pharmaceutical composition thereof, to a patient in need thereof.
    Type: Application
    Filed: October 10, 2007
    Publication date: April 16, 2009
    Applicant: Infinity Discovery, Inc.
    Inventors: Julian Adams, Mark L. Behnke, Alfredo C. Castro, Catherine A. Evans, Louis Grenier, Michael J. Grogan, Tao Liu, Daniel A. Snyder, Thomas T. Tibbitts
  • CYCLOPAMINE ANALOGS
    Publication number: 20090012109
    Abstract: The invention provides novel derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: August 27, 2008
    Publication date: January 8, 2009
    Inventors: Brian Austad, Mark L. Behnke, Alfredo C. Castro, Andre B. Charette, Michael J. Grogan, Somarajannair Janardanannair, Andre Lescarbeau, Stephane Peluso, Martin Tremblay
  • CYCLOPAMINE ANALOGS
    Publication number: 20080293754
    Abstract: The invention provides novel derivatives of cyclopamine having the following formula:
    Type: Application
    Filed: December 27, 2007
    Publication date: November 27, 2008
    Inventors: Brian Austad, Mark L. Behnke, Alfredo C. Castro, Andre B. Charette, Michael J. Grogan, Somarajannair Janardanannair, Andre Lescarbeau, Stephane Peluso, Martin Tremblay
  • HETEROCYCLIC CYCLOPAMINE ANALOGS AND METHODS OF USE THEREOF
    Publication number: 20080293755
    Abstract: The present invention relates to steroidal alkaloids that can be used in the treatment of hedgehog pathway related disorders, particularly cancer.
    Type: Application
    Filed: March 7, 2008
    Publication date: November 27, 2008
    Applicant: Infinity Discovery, Inc.
    Inventors: Alfredo C. Castro, Michael J. Grogan, Martin Tremblay
  • CYCLOPAMINE ANALOGUES AND METHODS OF USE THEREOF
    Publication number: 20080269272
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Application
    Filed: July 10, 2008
    Publication date: October 30, 2008
    Inventors: Julian Adams, Alfredo C. Castro, Michael A. Foley, Somarajan Nair Janardanan Nair, Marta Nevalainen, James R. Porter, Martin R. Tremblay
  • Cyclopamine analogues and methods of use thereof
    Patent number: 7407967
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Grant
    Filed: April 18, 2007
    Date of Patent: August 5, 2008
    Assignee: Infinity Pharmaceuticals, Inc.
    Inventors: Julian Adams, Alfredo C. Castro, Michael A. Foley, Somarajan Nair Janardanan Nair, Marta Nevalainen, James R. Porter, Martin R. Tremblay
  • Cyclopamine analogues and methods of use thereof
    Patent number: 7230004
    Abstract: The present invention provides compositions and methods for modulating smoothened-dependent pathway activation. The present invention provides analogs of cyclopamine that can be used to counteract the phenotypic effects of unwanted activation of a hedgehog pathway, such as resulting from hedgehog gain-of-function, Ptc loss-of-function or smoothened gain-of-function mutations. The compounds of the present invention are particularly useful in treating cancers.
    Type: Grant
    Filed: August 26, 2005
    Date of Patent: June 12, 2007
    Assignee: Infinity Discovery, Inc.
    Inventors: Julian Adams, Alfredo C. Castro, Michael A. Foley, Somarajan Nair Janardanan Nair, Marta Nevalainen, James R. Porter, Martin R. Tremblay
  • Cell adhesion inhibitors
    Patent number: 7001921
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Grant
    Filed: July 24, 2003
    Date of Patent: February 21, 2006
    Assignee: Biogen Idec MA Inc.
    Inventors: Steven P. Adams, Ko-Chung Lin, Wen-Cherng Lee, Alfredo C. Castro, Craig N. Zimmerman, Charles E. Hammond, Yu-Sheng Liao
  • Cell adhesion inhibitors
    Patent number: 6875743
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Grant
    Filed: November 28, 2000
    Date of Patent: April 5, 2005
    Assignee: Biogen, Inc.
    Inventors: Ko-Chung Lin, Steven P. Adams, Alfredo C. Castro, Craig N. Zimmerman, Julio Hernan Cuervo, Wen-Cherng Lee, Charles E. Hammond, Mary Beth Carter, Ronald G. Almquist
  • Cell adhesion inhibitors
    Patent number: 6630512
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Grant
    Filed: October 23, 2001
    Date of Patent: October 7, 2003
    Assignee: Biogen, Inc.
    Inventors: Steven P. Adams, Ko-Chung Lin, Wen-Cherng Lee, Alfredo C. Castro, Craig N. Zimmerman, Charles E. Hammond, Yu-Sheng Liao, Julio Hernan Cuervo, Juswinder Singh
  • Cell adhesion inhibitors
    Patent number: 6624152
    Abstract: The present invention relates to novel compounds that are useful for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. This invention also relates to pharmaceutical formulations comprising these compounds and methods of using them for inhibition and prevention of cell adhesion and cell adhesion-mediated pathologies. The compounds and pharmaceutical compositions of this invention can be used as therapeutic or prophylactic agents. They are particularly well-suited for treatment of many inflammatory and autoimmune diseases.
    Type: Grant
    Filed: August 22, 2001
    Date of Patent: September 23, 2003
    Assignee: Biogen, Inc.
    Inventors: Steven P. Adams, Ko-Chung Lin, Wen-Cherng Lee, Alfredo C. Castro, Craig N. Zimmerman, Charles E. Hammond, Yu-Sheng Liao