Patents by Inventor Alfredo Capretta

Alfredo Capretta has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA aptamers for eosinophil peroxidase detection
    Patent number: 12680104
    Abstract: This disclosure relates to DNA aptamers that bind eosinophil peroxidase, including uses thereof, such as in eosinophil peroxidase detection assays. Also provided is a method for detecting the presence of eosinophil peroxidase in a sample, using the DNA aptamers that bind eosinophil peroxidase. Further provided is a kit for detecting the presence of eosinophil peroxidase in a sample, using the DNA aptamers that bind eosinophil peroxidase.
    Type: Grant
    Filed: October 14, 2022
    Date of Patent: July 14, 2026
    Assignee: MCMASTER UNIVERSITY
    Inventors: John D. Brennan, Monsur Ali, Michael Wolfe, Dawn White, Manali Mukherjee, Parameswaran Nair, Alfredo Capretta
  • DNAzyme-based sensor for
    Patent number: 12674193
    Abstract: This disclosure relates to catalytic nucleic acid probes, biosensors and lateral flow biosensor systems and methods and kits of using the probes, biosensors and lateral flow biosensor systems for detecting microorganisms such as Staphylococcus aureus.
    Type: Grant
    Filed: November 18, 2022
    Date of Patent: July 7, 2026
    Assignee: MCMASTER UNIVERSITY
    Inventors: Monsur Ali, Dawn White, Saeed Mohammadi, John D. Brennan, Yingfu Li, Alfredo Capretta
  • DNAZYME FOR EOSINOPHIL PEROXIDASE AND USES THEREOF
    Publication number: 20260176675
    Abstract: This disclosure relates to catalytic nucleic acids, catalytic nucleic acid probes, biosensors, lateral flow devices, and kits for detecting the presence or absence of eosinophil peroxidase. Also provided are methods for detecting the presence or absence of eosinophil peroxidase in a test sample, using the catalytic nucleic acids, catalytic nucleic acid probes, biosensors, lateral flow devices, and kits.
    Type: Application
    Filed: November 9, 2023
    Publication date: June 25, 2026
    Inventors: Monsur Ali, Manali Mukherjee, Alfredo Capretta, Parameswaran Nair, John Brennan
  • MULTIVALENT TRIDENT APTAMERS FOR MOLECULAR RECOGNITION, METHODS OF MAKING AND USES THEREOF
    Publication number: 20260098270
    Abstract: Multivalent trident aptamers comprising the general formula [A-SA]2 or 3-L-[SB-B] in which a central branched linker molecule (L) possesses 2 or 3 variable arms ([A-SA]2 or 3), and a root ([SB-B]), connected by a central carbon atom, to provide enhanced affinity and/or avidity with a target are described, as well as methods of making and using the multivalent trident aptamers are provided.
    Type: Application
    Filed: September 22, 2023
    Publication date: April 9, 2026
    Applicant: MCMASTER UNIVERSITY
    Inventors: Yingfu LI, John BRENNAN, Jiuxing LI, Zijie ZHANG, Jimmy GU, Ryan AMINI, Alexandria MANSFIELD, Jianrun XIA, Dawn WHITE, Hannah D. STACEY, Jann C. ANG, Gurpreet PANESAR, Alfredo CAPRETTA, Carlos FILIPE, Karen MOSSMAN, Bruno J. SALENA, Cynthia BALION, Leyla SOLEYMANI, Matthew S. MILLER, Deborah YAMAMURA, Sam AFKHAMI, Michael Rein D'AGOSTINO
  • DNA APTAMERS FOR EOSINOPHIL PEROXIDASE DETECTION
    Publication number: 20230295635
    Abstract: This disclosure relates to DNA aptamers that bind eosinophil peroxidase, including uses thereof, such as in eosinophil peroxidase detection assays. Also provided is a method for detecting the presence of eosinophil peroxidase in a sample, using the DNA aptamers that bind eosinophil peroxidase. Further provided is a kit for detecting the presence of eosinophil peroxidase in a sample, using the DNA aptamers that bind eosinophil peroxidase.
    Type: Application
    Filed: October 14, 2022
    Publication date: September 21, 2023
    Inventors: John D. Brennan, Monsur Ali, Michael Wolfe, Dawn White, Manali Mukherjee, Parameswaran Nair, Alfredo Capretta
  • DNAZYME-BASED SENSOR FOR STAPHYLOCOCCUS AUREUS
    Publication number: 20230257802
    Abstract: This disclosure relates to catalytic nucleic acid probes, biosensors and lateral flow biosensor systems and methods and kits of using the probes, biosensors and lateral flow biosensor systems for detecting microorganisms such as Staphylococcus aureus.
    Type: Application
    Filed: November 18, 2022
    Publication date: August 17, 2023
    Inventors: Monsur Ali, Dawn White, Saeed Mohammadi, John D. Brennan, Yingfu Li, Alfredo Capretta