Patents by Inventor Alfredo DARMAN-IN-SHEEMAN

Alfredo DARMAN-IN-SHEEMAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synthetic library of specific binding molecules
    Patent number: 11459377
    Abstract: The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure represented by the following formula (I): FW 1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4 comprising (1) isolating RNA from a member of a species in the Elasmobranchii subclass; (2) amplifying DNA sequences from RNA obtained; (3) selecting a DNA sequence from the database prepared; (4) amplifying DNA sequences encoding two or more contiguous peptide domains of FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4; (5) ligating together said amplified DNA sequences to form DNA sequences encoding an antigen specific binding molecule; (6) cloning the amplified DNA obtained into a display vector; and (7) transforming a host with said display vector to produce a library of said antigen specific antigen binding molecules.
    Type: Grant
    Filed: February 11, 2019
    Date of Patent: October 4, 2022
    Assignee: ELASMOGEN LIMITED
    Inventors: Caroline Jane Barelle, William James Jonathan Finlay, Alfredo Darman-In-Sheeman, Andrew Justin Radcliffe Porter
  • SYNTHETIC LIBRARY OF SPECIFIC BINDING MOLECULES
    Publication number: 20200002403
    Abstract: The present invention provides methods for the production of a library of antigen specific antigen binding molecules having a peptide domain structure represented by the following formula (I): FW 1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4 comprising (1) isolating RNA from a member of a species in the Elasmobranchii subclass; (2) amplifying DNA sequences from RNA obtained; (3) selecting a DNA sequence from the database prepared; (4) amplifying DNA sequences encoding two or more contiguous peptide domains of FW1-CDR1-FW2-HV2-FW3a-HV4-FW3b-CDR3-FW4; (5) ligating together said amplified DNA sequences to form DNA sequences encoding an antigen specific binding molecule; (6) cloning the amplified DNA obtained into a display vector; and (7) transforming a host with said display vector to produce a library of said antigen specific antigen binding molecules.
    Type: Application
    Filed: February 11, 2019
    Publication date: January 2, 2020
    Applicant: THE UNIVERSITY COURT OF THE UNIVERSITY OF ABERDEEN
    Inventors: Caroline Jane BARELLE, William James Jonathan FINLAY, Alfredo DARMAN-IN-SHEEMAN, Andrew Justin Radcliffe PORTER