Abstract: A tissue ablating laser device (100) comprises a laser source (110) configured to generate a base laser beam (140) and a beam shaping optics (120) configured to receive the base laser beam (140) and to transform the base laser beam (140) to an emitting laser beam (143). The beam shaping optics (120) further is configured to focus the base laser beam (140) such that the emitting laser beam (143) has a focusing angle (142) of about 10° or less.

Abstract: A nozzle device (1) comprises a plurality of multi-fluid nozzles (5) and a body (2) with a bore (8). The bore (8) has a laser entrance (82) and a laser exit (81). The nozzle device (1) is adapted to be mounted to a laser medical device such that a laser beam generated by the laser medical device enters the laser entrance (82) of the bore (8) of the body (2) and exits the laser exit (81) of the bore (8) of the body (2). The body (2) houses the multi-fluid nozzles (5) and the multi-fluid nozzles (5) are arranged around the laser exit (81) of the bore (8) of the body (2). The nozzle device (1) allows to conditioning a tissue at and near where it is cut or drilled by the laser beam of the laser medical device. Thus, the nozzle device (1) is particularly suitable for a laser osteotomic device allowing to minimize collateral damages of the tissue when being cut or drilled.

Abstract: A laser source (101) comprises: (i) a first beam generating configuration (111, 112, 113) adapted to generate a pulsed primary ablating laser beam (162) with pulses having a first emission spectrum and a first temporal pulse width to ablate one type of tissue, (ii) a second beam generating configuration (121, 122, 123) adapted to generate a pulsed secondary ablating laser beam (163) with pulses having a second emission spectrum different from the first emission spectrum and a second temporal pulse width to ablate another type of tissue different than the one type of tissue ablated by the primary laser beam (162), (iii) a third beam generating configuration (121, 122, 123, 126) adapted to generate a pulsed analysis laser beam (161) with at least one pulse having a third emission spectrum and a third temporal pulse width shorter than the first temporal pulse width and shorter than the second temporal pulse width, and (iv) a beam directing optics (125) with beam aligning elements adapted to align the primary abl

Abstract: A cutting device for cutting a sternum of a patient comprises a laser source, a beam adjusting structure, a support and a correction arrangement. The laser source is adapted to generate a cut laser beam. The beam adjusting structure is arranged for directing the laser beam along a predefined cut geometry at the sternum. The support carries the laser source. The support has a mounting structure adapted to be fixed to a rib cage of the patient such that the laser source is in a predefined position with respect to the sternum. The correction arrangement is adapted to automatically identify a movement of the laser source relative to the sternum causing the cut laser beam to deviate from the predefined cut geometry and adjust the position of the laser source relative to the sternum to correct the deviation of the cut laser beam with respect to the predefined cut geometry.

Abstract: A method of cutting a bone (2) comprises the steps of: preparing the bone (2) in order to be accessible to an osteotomic instrument; predefining an osteotomic geometry on the bone (2); and applying the osteotomic instrument to the bone (2) thereby cutting the bone (2) along the osteotomic geometry and generating a cut surface (21) to the bone (2). The method further comprises delivering a laser beam to the cut surface (21) of the bone (2) such that the cut surface (21) of the bone (2) is ablated. The method according to the invention allows to improve healing of a bone at its cut surface after being cut by the osteotomic instrument.

Abstract: A laser device (100) has an ablation laser source (401) adapted to provide an ablating laser beam (402; 402i) for ablating a target tissue (120). It further comprises a plume analyzing arrangement (250) adapted to identify and/or quantify substances in the debris of the plume (110) generated by the ablating laser beam (402) ablating the target tissue (120) particularly substances being biomarkers of the ablated target tissue (120).

Abstract: A laser ablating device for cutting human or animal natural or artificial hard tissue includes: a cutting laser source adapted to provide a pulsed cutting laser beam lasing at a wavelength suitable for ablating the hard tissue; an imaging laser source adapted to provide an imaging laser beam covering a broadband spectral region; and a beam mixing structure and a movable scanner mirror positioned after the beam mixing structure. The beam mixing structure is adapted to redirect the cutting laser beam of the cutting laser source and/or the imaging laser beam of the imaging laser source such that an optical axis of the cutting laser beam is parallel to an optical axis of the imaging laser beam. The scanner mirror is arranged to direct the imaging laser beam and the cutting laser beam when having parallel optical axes.

Abstract: A cutting device for cutting a patient's sternum includes a laser source adapted to generate a cut laser beam, a beam adjusting structure arranged for directing the cut laser beam generated by the laser source along a predefined cut geometry at the sternum, a support that carries the laser source and, optionally, a correction arrangement. The support has a mounting structure adapted to be fixed to a patient's rib cage such that the laser source is in a predefined position with respect to the sternum. The correction arrangement is adapted to automatically identify a movement of the laser source relative to the sternum causing the cut laser beam to deviate from the predefined cut geometry. It is further adapted to automatically adjust the position of the laser source relative to the sternum to correct the deviation of the cut laser beam with respect to the predefined cut geometry.

Abstract: A photoablation device includes a laser source to propagate a focused laser beam with a beam waist, wherein a radius of the beam increases from the waist in a direction of propagation of the beam; an adjusting structure to adjust an intensity of the beam; a position detector to detect a position of the source in relation to the tissue; a positioning device to move the source in relation to the tissue; and a controller. The controller is to define a photoablation zone of the beam, wherein the zone ends in a cutting face located offset from the waist in the direction of propagation; adjust the intensity of the beam at the face of the zone using the adjusting structure; and move the beam towards the tissue by using the positioning device, wherein the position of the source detected by the position detector is evaluated.

Abstract: A Computer Assisted and Robot-Guided Laser Osteotome (CARLO) medical device (1) for perforating hard tissue, having a photoablation laser source (31) mounted in a robotic arm (2), and optical system (37) for focusing a laser beam in a target plane of the ostetomy line featuring an autotracking navigation system (8).

Abstract: A method of cutting a bone (2) comprises the steps of: preparing the bone (2) in order to be accessible to an osteotomic instrument; predefining an osteotomic geometry on the bone (2); and applying the osteotomic instrument to the bone (2) thereby cutting the bone (2) along the osteotomic geometry and generating a cut surface (21) to the bone (2). The method further comprises delivering a laser beam to the cut surface (21) of the bone (2) such that the cut surface (21) of the bone (2) is ablated. The method according to the invention allows to improve healing of a bone at its cut surface after being cut by the osteotomic instrument.

Abstract: A nozzle device (1) comprises a plurality of multi-fluid nozzles (5) and a body (2) with a bore (8). The bore (8) has a laser entrance (82) and a laser exit (81). The nozzle device (1) is adapted to be mounted to a laser medical device such that a laser beam generated by the laser medical device enters the laser entrance (82) of the bore (8) of the body (2) and exits the laser exit (81) of the bore (8) of the body (2). The body (2) houses the multi-fluid nozzles (5) and the multi-fluid nozzles (5) are arranged around the laser exit (81) of the bore (8) of the body (2). The nozzle device (1) allows to conditioning a tissue at and near where it is cut or drilled by the laser beam of the laser medical device. Thus, the nozzle device (1) is particularly suitable for a laser osteotomic device allowing to minimize collateral damages of the tissue when being cut or drilled.

Abstract: A photoablation device (1) for photoablation of human or animal tissue (8) comprises: a laser source (2) being arranged to propagate a focused laser beam (21) with a beam waist, wherein a radius of the laser beam (21) increases from the beam in waist into a direction of propagation (213) of the laser beam (21); an adjusting structure (41, 47) being arranged for adjusting an intensity of the laser beam (21); a position detector (6) for detecting a position of the laser source (2) in relation to the tissue (8); a positioning device (3) being arranged to move the laser source (2) in relation to the tissue (8); and a controller unit (4).

Abstract: A Computer Assisted and Robot-Guided Laser Osteotome (CARLO) medical device (1) for perforating hard tissue, having a photoablation laser source (31) mounted in a robotic arm (2), and optical system (37) for focusing a laser beam in a target plane of the ostetomy line featuring an autotracking navigation system (8).

Abstract: An optical detection arrangement for small volume chemical analysis comprises a light source (22), a capillary tube (23) and a photoelectric detector (24). The arrangement of the light source (22) relative to the capillary tube (23) is such, that probing light (P) emitted from the light source (22) strikes a sample (S) to be analyzed, which is flowing through the capillary tube (23), whereas the photoelectric detector (24) is arranged relative to the capillary tube (23) such, that it is capable of detecting light comming from the capillary tube. The photoelectric detector (24) is connected with an evaluation electronics.

Abstract: A flow cell for calorimetric measurements comprises a body (2) with at least one flow channel (3), which extends between an inlet opening (4) and an outlet opening (5), and a thermoelectric detector (16) for monitoring temperature changes, which occur during chemical or biochemical processes in a measuring volume (17). The measuring volume (17) is arranged in close vicinity of the outlet opening (5). The body (2) of the flow cell (1) has a good thermal conductivity of a magnitude such, that a fluid flowing through the flow channel (3) is thermostatizised prior to entering the measuring volume (17) solely by flowing through the flow channel (3) and free of any external thermostatization means. Thus, a flow cell is provided, which is capable of self-thermostatizing a fluid flowing therethrough.

Abstract: An interferometric apparatus for monitoring changes of the refractive index of An interferometri1capillary tubes comprising a source of coherent light, which is arranged with respect to a capillary tube which is part of a capillary liquid chromatographic system or a capillary electrophoretic system, such that the coherent light beam strikes the capillary tube about perpendicular to its longitudinal extension. In the forward direction of the coherent light beam, behind the capillary tube, the apparatus comprises a photoelectric detector for monitoring a resulting interference fringe pattern and the shifts thereof, which is connected to an evaluation electronics.

Abstract: An analytic separation arrangement includes a system of tubes including a separation zone, preferably a separation column, which tubes upstream the separation zone are connected with reservoirs for a carrier and a chemical sample to be seperated and analyzed, and downstream the separation zone are connected with a waste container for the carrier containing the sample and also are connected with transporting means for the carrier and the sample. The tube system is associated with an optical detector for monitoring changes in the absorption, in the fluorescence or in the optical activity of the carrier when it is transported through the tube system and past the optical detector, which is arranged in the path of the carrier behind the separation zone but in front of the waste container. Between the separation zone and the optical detector there is arranged in the path of the carrier a refractive index equalizing unit.

Abstract: A detection cell (4) is part of an interferometer for measuring changes in the refractive index of a medium located in a capillary (2). In order to simplify the evaluation of an interference fringe pattern, the capillary (2) is arranged in a matching fluid (15), the refractive index of which corresponds to that of the material of the capillary. The matching fluid (15) acts at the same time as a temperature-control bath for the capillary, thereby substantially increasing the temperature stability.