Abstract: Provided are compounds of Formula (I): or stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R1, R2, R3, and R4 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of using a compound of Formula (I), or stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing.

Abstract: Disclosed are novel compounds that accumulate in Gram-negative bacteria. Also disclosed are method of antimicrobial treatment using the compounds.

Abstract: Provided is a compound of formula (I): or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein A, B, X1, X2, X3, and X4 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of using a compound of formula (I), or a stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing.

Abstract: Provided are compounds of Formula (I): or stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing, wherein R1, R2, R3, and R4 are as defined herein. Also provided is a pharmaceutically acceptable composition comprising a compound of Formula (I), or stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing. Also provided are methods of using a compound of Formula (I), or stereoisomer or tautomer thereof, or a pharmaceutically acceptable salt of any of the foregoing.

Abstract: A non-impact method for testing either or both the rigidity and/or the stability of one or more loads placed on a carriage by subjecting the carriage to an acceleration single pulse profile including displacing the carriage in a first direction and accelerating the carriage according to the acceleration single pulse profile such that along part of the acceleration single pulse profile the carriage is displaced in a second direction opposite to the first direction. A device for testing stability and/or rigidity of one or more loads is also provided.

Abstract: Embodiments of the present disclosure are directed to a detailed lit indicator and touch detection in the same location through a metal surface. When the light behind the metal is turned off there will be no visible appearance of an indicator. When touched the metal will have no perceptible movement and never experience any deformation or evidence of usage over the life of the product.

Abstract: Disclosed are novel compounds that accumulate in Gram-negative bacteria. Also disclosed are method of antimicrobial treatment using the compounds.

Abstract: Disclosed are compounds that accumulate in Gram-negative bacteria. Also disclosed are method of antimicrobial treatment using the compounds.

Abstract: An bucket for a rope shovel provides a structure which is resistant to great mechanical forces and stress during operation of the bucket. The bucket comprises a tubular body (11) with an interior having a closed curvature (8). The tubular body (11) is formed by at least one plate (4) which is folded until its ends are butted and has weld beads (9a, 9b, 9c) and/or weld plugs (9c) to form the body (11) with a tubular shape. The tubular body (11) has an exterior with reinforcement layers (12, 13, 14, 15) comprising at least a plate (4). The lower front portion of the tubular body (11) has a lip (25) which is formed sheets (25a, 25b, 25c, 25d) that are overlapped and nested. Each sheet is formed by at least one plate (4). The upper portion of the tubular body (11) has engagement supports (20, 21, 22 which are also made of at least one plate (4).

Abstract: Disclosed are compounds that accumulate in Gram-negative bacteria. Also disclosed are method of antimicrobial treatment using the compounds.

Abstract: A bucket for a rope shovel formed as a resistant structure against great mechanical efforts which said bucket is subjected to during its operation, said bucket comprising a body (11) formed with a tubular shape leaving in its interior a closed curvature (8), wherein said body is formed by at least one plate (4) which is folded until its ends are butted, requiring weld beads (9a, 9b, 9c) and/or weld plugs (9c) in order to form said body (11) with a tubular shape, wherein said body (11) has in its exterior a plurality of reinforcement layers (12, 13, 14, 15) which are constituted by at least a plate (4) wherein on the lower front portion of the body (11) is present a lip (25) which is formed by a plurality of sheets (25a, 25b, 25c, 25d) overlapped and nested, each sheet being formed by at least one plate (4) wherein in the upper portion of the body (11) engagement means (20, 21, 22) are placed which are also made of at least one plate (4).

Abstract: The invention relates to a machine for testing cushioning material for packaging, which improves the test method and performs a more precise characterization of cushioning for packaging. The machine is formed by: a load arm (1); a lift motor (2) on the upper part thereof; several guides that connect (i) a rigid platform (6) for positioning the sample to be tested, replaceable by a load cell (6?), and (ii) an impact platform comprising sensors (7) for monitoring the position thereof and measuring acceleration during impact; a spindle (4) for moving the load arm; and, on the lower part thereof, a seismic mass (5) for reducing the transmission of the impact.

Abstract: The invention relates to a machine that simulates movement during transport, for the testing of packaging elements. The machine comprises: a load platform (1), the lower part of said platform having attached thereto a plurality of upper ball joints (3, 61,71) with a ±30° rotation angle, coplanar with the axis of rotation of a rotating support (5, 5?, 5?); and a lower platform (6) which is located opposite the load platform (1) and which is provided with anchors for attaching same to a vertical vibration table (25,26). Additionally, a central support (7) is located between the load platform (1) and the lower platform (6). Furthermore, a plurality of mutually independent hydraulic servo-actuators (8,8?,8?) are attached between the upper spherical ball joints (3) and the lower ball joints (4), said servo-actuators (8,8?,8?) being placed along two perpendicular planes that pass through the center of the rotating support (5, 5?, 5?), forming a 90° angle.

Abstract: A hopper box for a heavy lift truck such as mining trucks that minimizes the height of the gravity center of the load includes sheets that generate a floor, a front wall and two side walls. The sheets includes at least one sheet having a first longitudinal concave curved portion as a floor which continues with a longitudinal upper elongated portion which comprises the front wall thereby generating a single longitudinal curved, collapsed and elongated C-shaped sheet. A multiple number of such sheet may be provided and are placed in a juxtaposed manner until reaching the width by incorporating two side walls having on its lower face two longitudinal rigid U-shaped beams, wherein are also included half-round cross stiffeners on its ends.

Abstract: A process for preparing a compressed popcorn (15) food product is provided. Process steps include: cooking (1), cooling (2), fractioning (3), heating (4), compressing (5) and ejection and packing (6). Popcorn (15) is made from maize grains (13) which are then compressed (5) to obtain compressed food product portions. The invention also relates to a manufactured food product (53) comprising compressed popcorn (15) resulting from the maize grains (13) and a sweetener (14) cooked without the addition of fat substances. The resulting food product (53) may also include additional food ingredients. The different shapes of the compression containers (50) make it possible to obtain different types of candies, food bars or blocks, etc.

Abstract: A hopper box for a heavy lift truck such as mining trucks that minimizes the height of the gravity center of the load includes sheets that generate a floor, a front wall and two side walls. The sheets includes at least one sheet having a first longitudinal concave curved portion as a floor which continues with a longitudinal upper elongated portion which comprises the front wall thereby generating a single longitudinal curved, collapsed and elongated C-shaped sheet. A multiple number of such sheet may be provided and are placed in a juxtaposed manner until reaching the width by incorporating two side walls having on its lower face two longitudinal rigid U-shaped beams, wherein are also included half-round cross stiffeners on its ends.

Abstract: The invention relates to a device for limiting the speed of moving traffic. The device comprises at least one protruding element positioned on the surface of a road that is open to traffic. The protruding element wherein the shape and dimensions thereof are such that it affects only vehicles of certain sizes, the speed of which is going to be controlled. Likewise, vehicles travelling at an acceptable speed and along an appropriate path are also not affected by the device of the invention.

Abstract: The invention relates to a machine that simulates movement during transport, for the testing of packaging elements. The machine comprises: a load platform (1), the lower part of said platform having attached thereto a plurality of upper ball joints (3, 61,71) with a ±30° rotation angle, coplanar with the axis of rotation of a rotating support (5, 5?, 5?); and a lower platform (6) which is located opposite the load platform (1) and which is provided with anchors for attaching same to a vertical vibration table (25,26). Additionally, a central support (7) is located between the load platform (1) and the lower platform (6). Furthermore, a plurality of mutually independent hydraulic servo-actuators (8,8,8) are attached between the upper spherical ball joints (3) and the lower ball joints (4), said servo-actuators (8,8?,8?) being placed along two perpendicular planes that pass through the center of the rotating support (5, 5?, 5?), forming a 90° angle.

Abstract: The invention relates to a machine for testing cushioning material for packaging, which improves the test method and performs a more precise characterization of cushioning for packaging. The machine is formed by: a load arm (1); a lift motor (2) on the upper part thereof; several guides that connect (i) a rigid platform (6) for positioning the sample to be tested, replaceable by a load cell (6?), and (ii) an impact platform comprising sensors (7) for monitoring the position thereof and measuring acceleration during impact; a spindle (4) for moving the load arm; and, on the lower part thereof, a seismic mass (5) for reducing the transmission of the impact.

Abstract: The invention relates to a device for limiting the speed of moving traffic. The device comprises at least one protruding element designed to be positioned on the surface of a road that is open to traffic. The protruding element is characterized in that the shape and dimensions thereof are such that it affects only vehicles of certain sizes, the speed of which is to be controlled. Likewise, vehicles travelling at an acceptable speed and along an appropriate path are also not affected by the device of the invention.