Patents by Inventor Alfredo Giner-Sorolla

Alfredo Giner-Sorolla has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method of making inosine monophosphate derivatives and immunopotentiating uses thereof
    Patent number: 5614504
    Abstract: A method of making inosine-5'-monophosphate and its derivatives resistant to 5'-nucleotidase by chemically modifying inosine-5'-monophosphate to the formula: ##STR1## wherein R is selected from the group consisting of an alkyl, alkoxy and secondary amino compounds whereby inosine-5'-monophosphate biological activity is retained in vitro and extended to in vivo.
    Type: Grant
    Filed: April 21, 1995
    Date of Patent: March 25, 1997
    Assignee: The University of South Florida
    Inventors: John W. Hadden, Alfredo Giner-Sorolla
  • Methods of imparting immunomodulating activity with dihydrothiazolo purine derivatives
    Patent number: 4510144
    Abstract: There are prepared compounds of the formulae ##STR1## Where R.sup.1 is H, lower alkyl S--, ##STR2## NH.sub.2 or halogen, R.sup.2 is OH, lower alkyl S--, halogen, NH.sub.2 or SH,R is OH, SH, lower alkyl S--, or halogen andR.sup.3 is OH, SH, lower alkyl S--, halogen or NH.sub.2.The compounds have antiviral and immuno-modulating activity.
    Type: Grant
    Filed: September 30, 1982
    Date of Patent: April 9, 1985
    Assignee: Newport Pharmaceuticals International
    Inventors: John W. Hadden, Lionel N. Simon, Alfredo Giner-Sorolla
  • Method of imparting immunomodulating, antiviral or antitumor activity
    Patent number: 4457919
    Abstract: There are prepared compounds of the formula ##STR1## where R.sup.1 is alkyl of 1 to 8 carbon atoms and R.sup.2 is the ester group of an unsubstituted monocarboxylic acid, aromatic carboxylic acid, aminocarboxylic acid, unsubstituted dicarboxylic acid, phosphoric acid, or nitric acid or a glycoside or an acetaldehyde acetal. The compounds are immunomodulators, have antiviral activity and antitumor activity and also are enzyme inhibitors. The compounds can also be used to introduce the corresponding alcohol into biological systems, in some cases with enhanced potency.
    Type: Grant
    Filed: May 17, 1982
    Date of Patent: July 3, 1984
    Assignees: Newport Pharmaceutical International, Inc., Sloan-Kettering Institute
    Inventors: Lionel N. Simon, Alfredo Giner-Sorolla, Alvin Guttag
  • Purine-dihydrothiazoles
    Patent number: 4387226
    Abstract: There are prepared compound of the formulae ##STR1## Where R.sup.1 is H, lower alkyl S--, lower alkyl ##STR2## NH.sub.2 or halogen, R.sup.2 is OH, lower alkyl S--, halogen, NH.sub.2 or SHR is OH, SH, lower alkyl S--, or halogen andR.sup.3 is OH, SH, lower alkyl S--, halogen or NH.sub.2.The compounds have antiviral and immunomodulating activity.
    Type: Grant
    Filed: August 26, 1981
    Date of Patent: June 7, 1983
    Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute For Cancer Research
    Inventors: John W. Hadden, Lionel N. Simon, Alfredo Giner-Sorolla
  • Esters
    Patent number: 4340726
    Abstract: There are prepared compounds of the formula ##STR1## where R.sup.1 is alkyl of 1 to 8 carbon atoms and R.sup.2 is the ester group of an unsubstituted monocarboxylic acid, aromatic carboxylic acid, aminocarboxylic acid, unsubstituted dicarboxylic acid, phosphoric acid, or nitric acid or a glycoside or an acetaldehyde acetal. The compounds are immunomodulators, have antiviral activity and antitumor activity and also are enzyme inhibitors. The compounds can also be used to introduce the corresponding alcohol into biological systems, in some cases with enhanced potency.
    Type: Grant
    Filed: March 14, 1980
    Date of Patent: July 20, 1982
    Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute for Cancer Research
    Inventors: Lionel N. Simon, Alfredo Giner-Sorolla, Alvin Guttag
  • 9-(Hydroxy alkyl)purines
    Patent number: 4221910
    Abstract: There are prepared compounds of the formula ##STR1## where X is OH, R.sup.2 is CH.sub.3 and R.sup.1 is alkyl of 1 to 8 carbon atoms. The compounds are immunopotentiators, have antiviral activity and anti-leukemic activity.
    Type: Grant
    Filed: September 15, 1978
    Date of Patent: September 9, 1980
    Assignees: Newport Pharmaceuticals International, Inc., Sloan-Kettering Institute for Cancer Research
    Inventor: Alfredo Giner-Sorolla