Patents by Inventor Alfredo Molinolo

Alfredo Molinolo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS OF PREVENTING THE DEVELOPMENT OF MUCOSITIS AND RELATED DISORDERS
    Publication number: 20160184280
    Abstract: Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof comprising administering an effective amount of a mammalian target of rapamycin (mTOR) inhibitor, such as rapamycin, to the subject. Further disclosed is a method of increasing the lifespan of a normal oral keratinocyte and/or reducing oxidative stress in a normal epithelial cell, wherein the method comprises administering an effective amount of an mTOR inhibitor to a subject undergoing radiation therapy or chemotherapy for a disease in need thereof.
    Type: Application
    Filed: March 7, 2016
    Publication date: June 30, 2016
    Applicant: The United States of America, as represented by the Secretary, Department of Health and Human Serv
    Inventors: J. Silvio Gutkind, Ramiro Iglesias-Bartolome, Vyomesh Patel, Ana P. Cotrim, Alfredo Molinolo, James B. Mitchell
  • Methods of preventing the development of mucositis and related disorders
    Patent number: 9278090
    Abstract: Disclosed is a method of preventing the development of mucositis in a subject undergoing radiation therapy or chemotherapy for a disease in need thereof comprising administering an effective amount of a mammalian target of rapamycin (mTOR) inhibitor, such as rapamycin, to the subject. Further disclosed is a method of increasing the lifespan of a normal oral keratinocyte and/or reducing oxidative stress in a normal epithelial cell, wherein the method comprises administering an effective amount of an mTOR inhibitor to a subject undergoing radiation therapy or chemotherapy for a disease in need thereof.
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: March 8, 2016
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: J. Silvio Gutkind, Ramiro Iglesias-Bartolome, Vyomesh Patel, Ana p. Cotrim, Alfredo Molinolo, James B. Mitchell
  • Identification of DSG-3 as a biomarker for the detection of metastasis in lymph nodes
    Patent number: 9151762
    Abstract: Disclosed herein is a method of detecting metastasis of a tumor in a subject, such as metastasis to a lymph node. The method includes directly determining an amount of desmoglein-3 (DSG-3) protein in a sample from the subject (such as a lymph node sample) and comparing the amount of DSG-3 protein to a control, wherein an increase in the amount of DSG-3 protein in the sample relative to the control indicates metastasis of the tumor to the lymph node. The disclosed methods further include selecting a therapy (for example, surgery, lymph node dissection, radiation therapy, chemotherapy, or a combination of two or more thereof) for the subject based on the amount of DSG-3 protein in the sample from the subject.
    Type: Grant
    Filed: June 11, 2010
    Date of Patent: October 6, 2015
    Assignee: The United States of America, as represented by the Secretary, Department of Health and Human Services
    Inventors: J. Silvio Gutkind, Vyomesh Patel, Alfredo Molinolo, Timothy D. Veenstra
  • IDENTIFICATION OF DSG-3 AS A BIOMARKER FOR THE DETECTION OF METASTASIS IN LYMPH NODES
    Publication number: 20120087892
    Abstract: Disclosed herein is a method of detecting metastasis of a tumor in a subject, such as metastasis to a lymph node. The method includes directly determining an amount of desmoglein-3 (DSG-3) protein in a sample from the subject (such as a lymph node sample) and comparing the amount of DSG-3 protein to a control, wherein an increase in the amount of DSG-3 protein in the sample relative to the control indicates metastasis of the tumor to the lymph node. The disclosed methods further include selecting a therapy (for example, surgery, lymph node dissection, radiation therapy, chemotherapy, or a combination of two or more thereof) for the subject based on the amount of DSG-3 protein in the sample from the subject.
    Type: Application
    Filed: June 11, 2010
    Publication date: April 12, 2012
    Inventors: J. Silvio Gutkind, Vyomesh Patel, Alfredo Molinolo, Timothy D. Veenstra
  • CHEMOPREVENTION OF HEAD AND NECK SQUAMOUS CELL CARCINOMAS
    Publication number: 20110200556
    Abstract: Disclosed is a method for preventing the development of head and neck squamous cell carcinoma (HNSCC) in a mammal who is at risk for developing such carcinoma comprising administering an effective amount of a mammalian target of rapamycin (mTOR) inhibitor to the mammal. An example of such inhibitor is rapamycin.
    Type: Application
    Filed: August 20, 2009
    Publication date: August 18, 2011
    Applicant: THE UNITED STATES OF AMERICA, AS REPRESENTED BY TH E SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVI
    Inventors: J. Silvio Gutkind, Panomwat Amornphimoltham, Vyomesh Patel, Alfredo Molinolo, Rakefet Czerninski
  • Mouse mammary tumor lines expressing estrogen and progesterone receptors
    Patent number: 6808924
    Abstract: The invention relates to the generation of mouse mammary adenocarcinoma cell lines which express estrogen and progesterone receptors as a tool to study the effect of hormones, pharmacological compounds and environmental agents. The invention also relates methods in vitro and in vivo for testing hormones or another related molecules by cell proliferation or tumor proliferation.
    Type: Grant
    Filed: July 11, 2000
    Date of Patent: October 26, 2004
    Inventors: Claudia Lanari, Alfredo Molinolo, Isabel Luthy