Patents by Inventor Alfredo Paul Ceccarelli

Alfredo Paul Ceccarelli has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Processes for the preparation of apalutamide and intermediates thereof
    Patent number: 10513504
    Abstract: The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).
    Type: Grant
    Filed: March 6, 2019
    Date of Patent: December 24, 2019
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Alfredo Paul Ceccarelli, Michael R. Emmett, Avedis Karadeolian, Fabio E. S. Souza, Gamini Weeratunga, Boris Gorin
  • Processes for the Preparation of Apalutamide and Intermediates Thereof
    Publication number: 20190276424
    Abstract: The present invention provides processes for the preparation of Apalutamide (1), as well as intermediates useful in the preparation thereof. In particular, the process of the invention utilizes the intermediate compound of Formula (2), wherein G is OH or a leaving group, which provides improvements over the known processes for the preparation of Apalutamide (1).
    Type: Application
    Filed: March 6, 2019
    Publication date: September 12, 2019
    Inventors: Prabhudas Bodhuri, Alfredo Paul Ceccarelli, Michael R. Emmett, Avedis Karadeolian, Fabio E. S. Souza, Gamini Weeratunga, Boris Gorin
  • Processes for the preparation of edoxaban and intermediates thereof
    Patent number: 10301322
    Abstract: The present invention provides processes for the preparation of Edoxaban (1) and salts thereof, as well as intermediates thereof. In particular, intermediate compounds and/or salts of the Formulae (3), (4), (6-A), (7-A), (8-A), (9-A) and (10-AS) are provided.
    Type: Grant
    Filed: December 21, 2017
    Date of Patent: May 28, 2019
    Assignee: Apotex Inc.
    Inventors: Prabhudas Bodhuri, Avedis Karadeolian, Eduardo Gustavo Cammisa, Stuart P. Green, Melanie R. A. Green, Alfredo Paul Ceccarelli
  • Processes for the Preparation of Edoxaban and Intermediates Thereof
    Publication number: 20180179226
    Abstract: The present invention provides processes for the preparation of Edoxaban (1) and salts thereof, as well as intermediates thereof. In particular, intermediate compounds and/or salts of the Formulae (3), (4), (6-A), (7-A), (8-A), (9-A) and (10-AS) are provided.
    Type: Application
    Filed: December 21, 2017
    Publication date: June 28, 2018
    Inventors: Prabhudas Bodhuri, Avedis Karadeolian, Eduardo Gustavo Cammisa, Stuart P. Green, Melanie R. A. Green, Alfredo Paul Ceccarelli
  • Methods of making lubiprostone and intermediates thereof
    Patent number: 9382272
    Abstract: There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds.
    Type: Grant
    Filed: January 22, 2010
    Date of Patent: July 5, 2016
    Assignee: Apotex Pharmachem Inc.
    Inventors: Kiran Kumar Kothakonda, Fan Wang, Bhaskar Reddy Guntoori, Minh T. N. Nguyen, Alfredo Paul Ceccarelli, Yajun Zhao, Uma Kotipalli, Sammy Chris Duncan, Kaarina K. Milnes, Kevin Wade Kells, Laura Kaye Montemayor
  • Polymorphic forms of Lubiprostone
    Patent number: 8785663
    Abstract: There is provided a crystalline form of Lubiprostone, termed APO-II and methods for making APO-II. APO-II is a polymorphic form of Lubiprostone.
    Type: Grant
    Filed: January 28, 2011
    Date of Patent: July 22, 2014
    Inventors: Alfredo Paul Ceccarelli, Kiran Kumar Kothakonda
  • POLYMORPHIC FORMS OF LUBIPROSTONE
    Publication number: 20130096325
    Abstract: There is provided a crystalline form of Lubiprostone, termed APO-II and methods for making APO-II. APO-II is a polymorphic form of Lubiprostone.
    Type: Application
    Filed: January 28, 2011
    Publication date: April 18, 2013
    Applicant: APOTEX PHARMACHEM INC.
    Inventors: Alfredo Paul Ceccarelli, Kiran Kumar Kothakonda
  • Processes for the Purification of Lubiprostone
    Publication number: 20120309990
    Abstract: There is provided processes for purification of Lubiprostone by formation of amine salts. Also provided are compounds of the Lubiprostone amine salt. Also provided are compositions comprising Lubiprostone and amines.
    Type: Application
    Filed: December 17, 2010
    Publication date: December 6, 2012
    Applicant: APOTEX PHARMACHEM INC.
    Inventors: Gamini Weeratunga, Kiran Kumar Kothakonda, Alfredo Paul Ceccarelli, Bhaskar Reddy Guntoori, Fan Wang
  • METHODS OF MAKING LUBIPROSTONE AND INTERMEDIATES THEREOF
    Publication number: 20120065409
    Abstract: There is provided processes for preparing Lubiprostone and intermediates thereof. Also provided are compounds, including intermediates for preparing Lubiprostone as well compositions comprising Lubiprostone and other compounds, including intermediates for preparing Lubiprostone and other compounds.
    Type: Application
    Filed: January 22, 2010
    Publication date: March 15, 2012
    Applicant: APOTEX PHARMACHEM INC.
    Inventors: Kiran Kumar Kothakonda, Fan Wang, Bhaskar Reddy Guntoori, Minh T. N. Nguyen, Alfredo Paul Ceccarelli, Yajun Zhao, Uma Kotipalli, Sammy Chris Duncan, Kaarina K. Milnes, Kevin Wade Kells, Laura Kaye Montemayor
  • Process for the preparation of 17-N-substituted-carbamoyl-4-aza-androst-1-en-3-ones
    Patent number: 7531658
    Abstract: The present invention relates to a process for producing 17-N-substituted-carbamoyl-4-aza-androst-1-en-3-ones of formula 1, including Finasteride and Dutasteride.
    Type: Grant
    Filed: January 20, 2006
    Date of Patent: May 12, 2009
    Assignee: Apotex Pharmachem Inc.
    Inventors: Zhi-Xian Wang, Alfredo Paul Ceccarelli, Mohammed Abdul Raheem, Bhaskar Reddy Guntoori