Patents by Inventor Ali Can
Ali Can has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20110026803Abstract: Methods and systems for digitally enhancing an initial image of a material to which a plurality of stains were previously applied, that generally comprise: unmixing the image into a plurality of individual reconstructed images, each individual image corresponding to one of the stains; estimating a residual image corresponding to the difference between the original image and the reconstructed images; adjusting one or more components of the individual images; mixing the adjusted components using one or more estimated mixing coefficients; and adding the residual image to the mixed adjusted components to generate an enhanced image.Type: ApplicationFiled: July 31, 2009Publication date: February 3, 2011Applicant: GENERAL ELECTRIC COMPANYInventors: Ali Can, Cemal Cagatay Bilgin, Jens Rittscher, Robert John Filkins
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Publication number: 20100220910Abstract: An anomaly detection method and system for comparing a scanned object to an idealized object is provided. The anomaly detection method includes generating a three-dimensional reference model of the idealized object. The anomaly detection method further includes acquiring at least one two-dimensional inspection test image of the scanned object. The anamoly detection method also includes determining a two-dimensional reference image from the three-dimensional reference model using multiple pose parameters, wherein the two-dimensional reference image corresponds to the same view of the three-dimensional reference model of the idealized object as the view of the two-dimensional inspection test image of the scanned object. The anamoly detection method further includes identifying one or more defects in the inspection test image via automated defect recognition technique.Type: ApplicationFiled: March 2, 2009Publication date: September 2, 2010Applicant: GENERAL ELECTRIC COMPANYInventors: Robert August Kaucic, James Vradenburg Miller, Ali Can, Zhaohui Sun, Xiaodong Tao
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Patent number: 7741045Abstract: Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one or more target present in the sample. The methods include the steps of observing a signal from the fluorescent probe and a control signal from the control probe and applying to the sample a basic solution containing an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe. The methods further include the steps of binding at least one fluorescent probe to one or more target present in the sample and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.Type: GrantFiled: September 28, 2007Date of Patent: June 22, 2010Assignee: General Electric CompanyInventors: Michael J. Gerdes, Anup Sood, Michael Christopher Montalto, Ali Can, Fiona Ginty, Maureen Ann Bresnahan, Robert John Filkins, Zhengyu Pang
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Publication number: 20090279772Abstract: An anomaly detection method includes acquiring image data corresponding to nondestructive testing (NDT) of a scanned object. The NDT image data comprises at least one inspection test image of the scanned object and multiple reference images for the scanned object. The anomaly detection method further includes generating an anomaly detection model based on a statistical analysis of one or more image features in the reference images for the scanned object and identifying one or more defects in the inspection test image, based on the anomaly detection model.Type: ApplicationFiled: May 12, 2008Publication date: November 12, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Zhaohui Sun, Ali Can, John Charles Janning, Robert August Kaucic, Paulo Ricardo Mendonca, Joseph Manuel Portaz
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Publication number: 20090247416Abstract: The present techniques include methods and systems for finding correspondences between tissue spots in tissue microarray serial sections belonging to the same recipient block. The present techniques may also be used to relate individual tissue cores to clinical information. Using either a whole slide image or the relative x-y coordinates of the tissue spots on the slide, individual tissue spots in different tissue microarrays may be linked to one another and their clinical information.Type: ApplicationFiled: March 25, 2008Publication date: October 1, 2009Applicant: General Electric CompanyInventors: Ali Can, Michael John Gerdes, Musodiq Olatayo Bello, Xiaodong Tao, Maximilian Seel
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Publication number: 20090245598Abstract: The present techniques provide fully automated methods for quantifying the location, strength and percent of expressed target molecules or other biological markers in immunohistochemically stained biological samples. The samples may be automatically segmented, for example into subcellular compartments, from images of compartmental markers. Then, the distribution of a target molecule on each of these compartments is calculated that includes the percentage and strength of expression. This is different than existing intensity or ratio based methods where abundant low expression levels are indistinguishable from scarce high expression levels.Type: ApplicationFiled: March 26, 2008Publication date: October 1, 2009Applicant: General Electric CompanyInventors: Ali Can, Michael John Gerdes, Musodiq Olatayo Bello, Xiaodong Tao
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Publication number: 20090245610Abstract: The present techniques provide systems and methods for registering images of tissue spots on a tissue microarray (TMA). In studies involving multiple biomarkers being studied on the same TMA, the TMA slide is removed from the microscope, stained, and then imaged, often multiple times. The present techniques relate to validation of the registration of the acquired images of the same TMA. An automatic approach to register the images and detect registration failures as provided herein may enhance the rapid analysis of the tissues. Artifacts such as tissue folding and tissue loss are also determined automatically.Type: ApplicationFiled: March 25, 2008Publication date: October 1, 2009Applicant: General Electric CompanyInventors: Ali Can, Michael John Gerdes, Xiaodong Tao, Musodiq Olatayo Bello, Maximilian Seel
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Publication number: 20090245611Abstract: Techniques for removing image autoflourescence from fluorescently stained biological images are provided herein. The techniques utilize non-negative matrix factorization that may constrain mixing coefficients to be non-negative. The probability of convergence to local minima is reduced by using smoothness constraints. The non-negative matrix factorization algorithm provides the advantage of removing both dark current and autofluorescence.Type: ApplicationFiled: March 26, 2008Publication date: October 1, 2009Applicant: General Electric CompanyInventors: Ali Can, Michael John Gerdes, Musodiq Olatayo Bello, Xiaodong Tao, Francis Edward Pavan-Woolfe, Roshni Bhagalia
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Publication number: 20090238432Abstract: A method for identifying defects in radiographic image data corresponding to a scanned object is provided. The method includes acquiring radiographic image data corresponding to a scanned object. In one embodiment, the radiographic image data includes an inspection test image and a reference image corresponding to the scanned object. The method includes identifying one or more regions of interest in the reference image and aligning the inspection test image with the regions of interest identified in the reference image, to obtain a residual image. The method further includes identifying one or more defects in the inspection test image based upon the residual image and one or more defect probability values computed for one or more pixels in the residual image.Type: ApplicationFiled: March 21, 2008Publication date: September 24, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Ali Can, Robert August Kaucic, Paulo Ricardo Mendonca, Zhaohui Sun, Joseph Manuel Portaz
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Publication number: 20090141959Abstract: Method and systems for removing any inherent autofluorescence associated with a biological material, comprising: acquiring a first reference image of the biological material; acquiring a first set of one or more images of the biological material using one or more filters corresponding to one or more information dyes; applying the one or more additional dyes to the biological material and then acquiring a second set of one or more images comprising a separate image of the biological material with each of the filters corresponding to the information dyes and a second reference image of the biological material; coregistering the first and second reference images; and then removing any inherent autofluorescence exhibited in the informational images acquired.Type: ApplicationFiled: November 30, 2007Publication date: June 4, 2009Applicant: GENERAL ELECTRIC COMPANYInventors: Ali Can, Michael John Gerdes, Harvey Ellis Cline
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Publication number: 20080118934Abstract: Methods for probing multiple targets in a biological sample are provided. The methods include the steps of providing a biological sample containing multiple targets, binding at least one fluorescent probe to one or more target present in the sample, and binding at least at least one control probe to one or more target present in the sample. The methods include the steps of observing a signal from the fluorescent probe and a control signal from the control probe and applying to the sample a basic solution containing an oxidizing agent that selectively inactivates the fluorescent probe and not the control probe. The methods further include the steps of binding at least one fluorescent probe to one or more target present in the sample and observing a signal from the fluorescent probe. The methods disclosed herein also provide for multiple iterations of binding, observing, and oxidizing for deriving information about multiple targets in a single sample. An associated kit is also provided.Type: ApplicationFiled: September 28, 2007Publication date: May 22, 2008Applicant: GENERAL ELECTRIC COMPANYInventors: Michael J. Gerdes, Anup Sood, Michael Christopher Montalto, Ali Can, Fiona Ginty, Maureen Ann Bresnahan, Robert John Filkins, Zhengyu Pang
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Publication number: 20080032328Abstract: A system and methods for co-registering multi-channel images of a tissue micro array, comprising the steps of, providing a biological material on a substrate; applying one or more molecular probes, adapted to provide fluorescent molecular markers, to the biological material; obtaining a first digital image of the biological material and the fluorescent molecular markers; applying a morphological stain to the biological material; obtaining a second digital image of the biological material, computing information common to the first and second images; and co-registering the second image with the first image based on one or more registration metrics.Type: ApplicationFiled: August 7, 2006Publication date: February 7, 2008Inventors: Harvey Ellis Cline, Ali Can
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Publication number: 20080031521Abstract: Methods and systems for segmenting images, wherein the image pixels are categorized into a plurality of subsets using one or more indexes, then a log-likelihood function of one or more of the indexes is determined, and one or more maps are generated based on the determination of the log-likelihood function of one or more of the indexes.Type: ApplicationFiled: February 28, 2007Publication date: February 7, 2008Applicant: GENERAL ELECTRIC COMPANYInventors: Ali Can, Xiaodong Tao, Harvey Ellis Cline, Paulo Ricardo Mendonca
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Publication number: 20080032321Abstract: A system for analyzing tissue samples, comprising: a storage device for at least temporarily storing one or more images of one or more cells, wherein at least one of the images is indicative of one or more channels comprising a receptor tyrosine kinase (RTK); and a processing device that determines an extent to which one or more of the RTKs may have translocated from at least one subcellular region to another subcellular region of one or more of the cells; and generates a score based at least in part on the RTK translocation.Type: ApplicationFiled: March 15, 2007Publication date: February 7, 2008Applicant: GENERAL ELECTRIC COMPANYInventors: FIONA GINTY, ROBERT JOHN FILKINS, HARVEY ELLIS CLINE, MICHAEL CHRISTOPHER MONTALTO, SUDESHNA ADAK, ALI CAN, MICHAEL JOHN GERDES, MELINDA LARSEN
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Publication number: 20080033657Abstract: A system for analyzing tissue samples, that generally comprises, a storage device for at least temporarily storing one or more images of one or more cells, wherein the images comprise a plurality of channels; and a processor that is adapted to determine the extent to which a biomarker may have translocated from at least one subcellular region to another subcellular region; and then to generate a score corresponding to the extent of translocation.Type: ApplicationFiled: November 30, 2006Publication date: February 7, 2008Inventors: Harvey Ellis Cline, Ali Can, Xiaodong Tao, Robert John Filkins, Maximilian Lewis Seel, Michael Christopher Montalto
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Patent number: 6094621Abstract: A method for determining migration before summation including recording seismic reflection traces, for constituting a collection of traces to be migrated before summation and without weight correction. The traces being classified according to a given criterion and using a velocity model. The method including determining, for each point of interest M in a domain (X, Z), at least one line of slope determined on the basis of a line of slope map, in determining the specular rays associated with one point M and for the line of slope, and in computing the time and amplitude characteristics of each of the specular rays for deducing therefrom the reflection factor in each point M.Type: GrantFiled: June 26, 1998Date of Patent: July 25, 2000Assignee: Elf Exploration ProductionInventors: Christian Hanitzsch, Side Jin, Mehmet Ali Can Tura