Abstract: Systems and methods for in-line spectroscopic compound analysis are provided. The in-line spectroscopic compound analysis system comprises a reference optical flow cell to continuously receive a reference fluid, a plurality of sample optical flow cells to continuously receive a sample fluid and a single electromagnetic radiation (EMR) source. The system includes a multichannel optical switch for receiving the EMR from the single EMR source. Each EMR beam passes through each of the reference optical flow cell and the sample optical flow cells. The system also includes a plurality of detectors, each of which receiving EMR from each of the reference optical flow cell and the sample optical flow cells. The system further comprises a controller operably coupled with the detectors and configured to continuously detect a property of the sample in each of the sample optical flow cells with respect to the reference optical flow cell.

Abstract: Systems and methods for in-line spectroscopic compound analysis are provided. The in-line spectroscopic compound analysis system comprises a reference optical flow cell to continuously receive a reference fluid, a plurality of sample optical flow cells to continuously receive a sample fluid and a single electromagnetic radiation (EMR) source. The system includes a multichannel optical switch for receiving the EMR from the single EMR source. Each EMR beam passes through each of the reference optical flow cell and the sample optical flow cells. The system also includes a plurality of detectors, each of which receiving EMR from each of the reference optical flow cell and the sample optical flow cells. The system further comprises a controller operably coupled with the detectors and configured to continuously detect a property of the sample in each of the sample optical flow cells with respect to the reference optical flow cell.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: A system for measuring and controlling foot temperature. The system comprises a heating or cooling device including one or more sealed fluidic pathways having a cooling or heating fluid therein and disposed in or on an article of footwear or a sock. A pumping device coupled to the heating or cooling device is configured to circulate the fluid in the one or more sealed fluidic pathways. A heat exchanger coupled to the heating or cooling device is configured to remove or add heat from or to the fluid in the one or more sealed fluidic pathways. A controller coupled to the pumping device and the heat exchanger is configured to control the pumping device and the heat exchanger to cool or heat a foot located inside the article of footwear or the sock.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: Provided herein are, inter alia, biological manufacturing and downstream purification processes.

Abstract: Continuous monitoring of blood cultures using pH- (or CO2—) based detection platforms is the current clinical gold standard. Despite the ubiquity of these systems in state-of-the-art clinical microbiology laboratories, they offer slow times-to-result (TTR) because microorganism detection typically requires >109 colony forming units (CFU) to be present whereas only 1-1000 CFU are typically present in septic patient blood samples. These TTRs are further lengthened for samples collected from spoke sites in consolidated hub-and-spoke laboratory models, an increasingly common model for integrated hospital networks and reference laboratories, because sample transport time, typically >4 hours, is lost. Here we introduce new methods that allow microorganisms to be detected at <105 CFU and that enable sample incubation during courier transport from spoke collection sites to the central laboratory hub.

Abstract: A system for measuring and controlling foot temperature. The system comprises a heating or cooling device including one or more sealed fluidic pathways having a cooling or heating fluid therein and disposed in or on an article of footwear or a sock. A pumping device coupled to the heating or cooling device is configured to circulate the fluid in the one or more sealed fluidic pathways. A heat exchanger coupled to the heating or cooling device is configured to remove or add heat from or to the fluid in the one or more sealed fluidic pathways. A controller coupled to the pumping device and the heat exchanger is configured to control the pumping device and the heat exchanger to cool or heat a foot located inside the article of footwear or the sock.

Abstract: The present disclosure provides advantageous optical conduit assemblies (e.g., biocompatible and implantable optical conduit assemblies), and related methods of use. More particularly, the present disclosure provides advantageous optical conduit assemblies (e.g., polydimethylsiloxane (“PDMS”)-based optical conduit assemblies) configured to power implantable devices (e.g., neural micro-stimulators or deep brain stimulators or the like) or to be used in optogenetic stimulation. In general, the exemplary optical conduit assemblies can be used for applications where energy needs to be transmitted to deep locations inside the body or brain without using electrical wires. Therefore, implantable devices that need to be powered (e.g., neural prosthetics) can be powered from an external light source using an optical conduit and an optical-to-electrical converter (e.g., a photodiode) attached to the end of the optical conduit on the inside.

Abstract: The present disclosure provides advantageous optical conduit assemblies (e.g., biocompatible and implantable optical conduit assemblies), and related methods of use. More particularly, the present disclosure provides advantageous optical conduit assemblies (e.g., polydimethylsiloxane (“PDMS”)-based optical conduit assemblies) configured to power implantable devices (e.g., neural micro-stimulators or deep brain stimulators or the like) or to be used in optogenetic stimulation. In general, the exemplary optical conduit assemblies can be used for applications where energy needs to be transmitted to deep locations inside the body or brain without using electrical wires. Therefore, implantable devices that need to be powered (e.g., neural prosthetics) can be powered from an external light source using an optical conduit and an optical-to-electrical converter (e.g., a photodiode) attached to the end of the optical conduit on the inside.

Abstract: Processes increase light absorption into silicon wafers by selectively changing the reflective properties of the bottom portions of light trapping cavity features. Modification of light trapping features includes: deepening the bottom portion, increasing the curvature of the bottom portion, and roughening the bottom portion, all accomplished through etching. Modification may also be by the selective addition of material at the bottom of cavity features. Different types of features in the same wafers may be treated differently. Some may receive a treatment that improves light trapping while another is deliberately excluded from such treatment. Some may be deepened, some roughened, some both. No alignment is needed to achieve this selectively. The masking step achieves self-alignment to previously created light trapping features due to softening and deformation in place.

Abstract: Materials that contain liquid are deposited into grooves upon a surface of a work piece, such as a silicon wafer to form a solar cell. Liquid can be dispensed into work piece paths, such as grooves under pressure through a dispensing tube. The tube mechanically tracks in the groove. The tube may be small and rest at the groove bottom, with the sidewalls providing restraint. Or it may be larger and ride on the top edges of the groove. A tracking feature, such as a protrusion, Non-circular cross-sections, molded-on protrusions and lobes also enhance tracking. The tube may be forced against the groove by spring or magnetic loading. Alignment guides, such as lead-in features may guide the tube into the groove. Restoring features along the path may restore a wayward tube. Many tubes may be used. Many work pieces can be treated in a line or on a drum.

Abstract: A small transparent display with a silicon active backplane on a transparent substrate, an array of pixel transparent electrodes on top of and controlled by the silicon active backplane, a transparent common plate, a liquid crystal material between alignment layers on the backplane and common plate, and a polarizer fabricated on the silicon active backplane. The polarizer corrects for depolarization of light passing through the transparent substrate and the silicon active backplane to improve the contrast of the display.

Abstract: A small transparent display with a silicon active backplane on a transparent substrate, an array of pixel transparent electrodes on top of and controlled by the silicon active backplane, a transparent common plate, a liquid crystal material between alignment layers on the backplane and common plate, and a polarizer fabricated on the silicon active backplane. The polarizer corrects for depolarization of light passing through the transparent substrate and the silicon active backplane to improve the contrast of the display.