Patents by Inventor Ali Ghoorchian

Ali Ghoorchian has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Systems and devices for protease detection based on engineered polymers and biopolymers and methods of use
    Patent number: 11268127
    Abstract: The presently disclosed subject matter relates to modular peptide-substrate protease assays, in particular low cost and reliable methodology for measurement of protease and other enzyme activity that may be detected by optical turbidimetry or visual observation. The presently disclosed subject matter also relates to methods of using the disclosed assays within methods of detecting and monitoring diseases, methods of drug discovery, as well as in detection devices and systems.
    Type: Grant
    Filed: February 4, 2015
    Date of Patent: March 8, 2022
    Assignee: Duke University
    Inventors: Gabriel P. Lopez, Ashutosh Chilkoti, Ali Ghoorchian, Felipe Garcia Quiroz
  • Hydrogels formed from polypeptide micelles and methods of use thereof
    Patent number: 9956300
    Abstract: The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: May 1, 2018
    Assignee: Duke Univerity
    Inventors: Gabriel P. Lopez, Ashutosh Chilkoti, Ali Ghoorchian, Joseph R. Simon
  • SYSTEMS AND DEVICES FOR PROTEASE DETECTION BASED ON ENGINEERED POLYMERS AND BIOPOLYMERS AND METHODS OF USE
    Publication number: 20160348147
    Abstract: The presently disclosed subject matter relates to modular peptide-substrate protease assays, in particular low cost and reliable methodology for measurement of protease and other enzyme activity that may be detected by optical turbidimetry or visual observation. The presently disclosed subject matter also relates to methods of using the disclosed assays within methods of detecting and monitoring diseases, methods of drug discovery, as well as in detection devices and systems.
    Type: Application
    Filed: February 4, 2015
    Publication date: December 1, 2016
    Inventors: Gabriel P. Lopez, Ashutosh Chilkoti, Ali Ghoorchian, Felipe Garcia
  • HYDROGELS FORMED FROM POLYPEPTIDE MICELLES AND METHODS OF USE THEREOF
    Publication number: 20160271262
    Abstract: The presently disclosed subject matter is directed to compositions, methods, and systems (e.g., platforms) comprising the same, the systems comprising, consisting of, or consisting essentially of micro- and macro-hydrogels that are formed from polypeptide micelles. The systems have enhanced mechanical properties that can be useful in a wide variety of applications, can be used for controlled release of drug-loaded micelles, and can be designed to reversibly assemble and disassemble on demand.
    Type: Application
    Filed: March 18, 2016
    Publication date: September 22, 2016
    Inventors: Gabriel P. Lopez, Ashutosh Chilkoti, Ali Ghoorchian, Joseph R. Simon