Patents by Inventor Ali Hafezi-Moghadam

Ali Hafezi-Moghadam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190076406
    Abstract: The invention relates generally to methods and compositions for treating conditions associated with angiogenesis, and, more specifically, the invention relates to methods and compositions for treating conditions associated with angiogenesis using vascular adhesion protein-1 (VAP-1) inhibitors. The invention also relates to methods and compositions for treating conditions associated with lymphangiogenesis using VAP-1 inhibitors.
    Type: Application
    Filed: May 2, 2018
    Publication date: March 14, 2019
    Inventor: Ali Hafezi-Moghadam
  • Patent number: 10183054
    Abstract: The present invention relates generally to a composition comprising palm fruit juice for use in a method of preventing and inhibiting vision loss due to angiogenesis related diseases. The composition of the present invention aids to decrease in CNV size using confocal microscopy, in addition to reduction in macrophage infiltration using immune staining; decrease in VEGF-A-induced angiogenesis using established cornea pocket assay, inhibition of IKB-D phosphorylation in laser treated choroidal tissues and reduction in macrophage recruitment to CNV lesions.
    Type: Grant
    Filed: April 17, 2017
    Date of Patent: January 22, 2019
    Assignee: MALAYSIAN PALM OIL BOARD
    Inventors: Ravigadevi Sambanthamurthi, Yew Ai Tan, Ali Hafezi-Moghadam
  • Publication number: 20180146852
    Abstract: This invention relates generally to minimally-invasive, in vivo methods of detecting one or more ligands on an intraluminal surface of a blood vessel using microparticles coated with one or more ligand binding partners. More particularly, in certain embodiments, the invention relates to minimally-invasive, in vivo methods of detecting endothelial and leukocyte antigens that are predictive of diabetic retinopathy (DR) and/or other conditions using protein-conjugated microparticles detectable by a non-invasive detection system, for example, a scanning laser ophthalmoscope. In other embodiments, the invention relates to targeted delivery of drugs or other substances to specific regions of an intraluminal surface of a blood vessel using drug-containing microparticles coated with one or more ligand binding partners.
    Type: Application
    Filed: August 16, 2017
    Publication date: May 31, 2018
    Inventor: Ali Hafezi-Moghadam
  • Publication number: 20180110837
    Abstract: The technology described herein is directed to methods and assay related to macrophage differentiation and the role of such in pathogenesis.
    Type: Application
    Filed: June 13, 2017
    Publication date: April 26, 2018
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventor: Ali HAFEZI-MOGHADAM
  • Publication number: 20180000791
    Abstract: The invention relates generally to methods and compositions for treating conditions associated with angiogenesis, and, more specifically, the invention relates to methods and compositions for treating conditions associated with angiogenesis using vascular adhesion protein-1 (VAP-1) inhibitors. The invention also relates to methods and compositions for treating conditions associated with lymphangiogenesis using VAP-1 inhibitors.
    Type: Application
    Filed: February 10, 2017
    Publication date: January 4, 2018
    Applicant: MASSACHUSETTS EYE & EAR INFIRMARY
    Inventor: Ali Hafezi-Moghadam
  • Publication number: 20170274035
    Abstract: The present invention relates generally to a composition comprising palm fruit juice for use in a method of preventing and inhibiting vision loss due to angiogenesis related diseases. The composition of the present invention aids to decrease in CNV size using confocal microscopy, in addition to reduction in macrophage infiltration using immune staining; decrease in VEGF-A-induced angiogenesis using established cornea pocket assay, inhibition of IKB-D phosphorylation in laser treated choroidal tissues and reduction in macrophage recruitment to CNV lesions.
    Type: Application
    Filed: April 17, 2017
    Publication date: September 28, 2017
    Applicant: Malaysian Palm Oil Board
    Inventors: Ravigadevi SAMBANTHAMURTHI, Yew Ai TAN, Ali HAFEZI-MOGHADAM
  • Publication number: 20160279104
    Abstract: The invention relates generally to methods and compositions for treating conditions associated with angiogenesis, and, more specifically, the invention relates to methods and compositions for treating conditions associated with angiogenesis using vascular adhesion protein-1 (VAP-1) inhibitors. The invention also relates to methods and compositions for treating conditions associated with lymphangiogenesis using VAP-1 inhibitors.
    Type: Application
    Filed: November 9, 2015
    Publication date: September 29, 2016
    Inventor: Ali Hafezi-Moghadam
  • Publication number: 20160235297
    Abstract: This invention relates generally to minimally-invasive, in vivo methods of detecting one or more ligands on an intraluminal surface of a blood vessel using microparticles coated with one or more ligand binding partners. More particularly, in certain embodiments, the invention relates to minimally-invasive, in vivo methods of detecting endothelial and leukocyte antigens that are predictive of diabetic retinopathy (DR) and/or other conditions using protein-conjugated microparticles detectable by a non-invasive detection system, for example, a scanning laser ophthalmoscope. In other embodiments, the invention relates to targeted delivery of drugs or other substances to specific regions of an intraluminal surface of a blood vessel using drug-containing microparticles coated with one or more ligand binding partners.
    Type: Application
    Filed: October 12, 2015
    Publication date: August 18, 2016
    Inventor: Ali Hafezi-Moghadam
  • Publication number: 20150297679
    Abstract: The technology described herein is directed to methods and assay related to macrophage differentiation and the role of such in pathogenesis.
    Type: Application
    Filed: December 13, 2013
    Publication date: October 22, 2015
    Inventor: Ali HAFEZI-MOGHADAM
  • Publication number: 20150030710
    Abstract: The present invention relates generally to a composition comprising palm fruit juice for use in a method of preventing and inhibiting vision loss due to angiogenesis related diseases. The composition of the present invention aids to decrease in CNV size using confocal microscopy, in addition to reduction in macrophage infiltration using immune staining; decrease in VEGF-A-induced angiogenesis using established cornea pocket assay, inhibition of IKB-D phosphorylation in laser treated choroidal tissues and reduction in macrophage recruitment to CNV lesions.
    Type: Application
    Filed: August 5, 2014
    Publication date: January 29, 2015
    Inventors: Ali Hafezi MOGHADAM, Ravigadevi SAMBANTHAMURTHI, Yew Ai TAN, Kalyana Sundram P. MANICKAM, Kenneth C. HAYES, Zandi SOUSKA
  • Publication number: 20140170160
    Abstract: The invention relates generally to methods and compositions for treating conditions associated with angiogenesis, and, more specifically, the invention relates to methods and compositions for treating conditions associated with angiogenesis using vascular adhesion protein-1 (VAP-1) inhibitors. The invention also relates to methods and compositions for treating conditions associated with lymphangiogenesis using VAP-1 inhibitors.
    Type: Application
    Filed: November 1, 2013
    Publication date: June 19, 2014
    Applicant: MASSACHUSETTS EYE & EAR INFIRMARY
    Inventor: Ali Hafezi-Moghadam
  • Publication number: 20120276111
    Abstract: The invention relates generally to methods and compositions for treating conditions associated with angiogenesis, and, more specifically, the invention relates to methods and compositions for treating conditions associated with angiogenesis using vascular adhesion protein-1 (VAP-1) inhibitors. The invention also relates to methods and compositions for treating conditions associated with lymphangiogenesis using VAP-1 inhibitors.
    Type: Application
    Filed: November 30, 2011
    Publication date: November 1, 2012
    Inventor: Ali Hafezi-Moghadam
  • Publication number: 20090170770
    Abstract: The invention relates generally to methods and compositions for treating conditions associated with angiogenesis, and, more specifically, the invention relates to methods and compositions for treating conditions associated with angiogenesis using vascular adhesion protein-1 (VAP-1) inhibitors. The invention also relates to methods and compositions for treating conditions associated with lymphangiogenesis using VAP-1 inhibitors.
    Type: Application
    Filed: November 5, 2008
    Publication date: July 2, 2009
    Inventor: Ali Hafezi-Moghadam
  • Publication number: 20080305046
    Abstract: This invention relates generally to minimally-invasive, in vivo methods of detecting one or more ligands on an intraluminal surface of a blood vessel using microparticles coated with one or more ligand binding partners. More particularly, in certain embodiments, the invention relates to minimally-invasive, in vivo methods of detecting endothelial and leukocyte antigens that are predictive of diabetic retinopathy (DR) and/or other conditions using protein-conjugated microparticles detectable by a non-invasive detection system, for example, a scanning laser opthalmoscope. In other embodiments, the invention relates to targeted delivery of drugs or other substances to specific regions of an intraluminal surface of a blood vessel using drug-containing microparticles coated with one or more ligand binding partners.
    Type: Application
    Filed: January 7, 2008
    Publication date: December 11, 2008
    Inventor: Ali Hafezi-Moghadam
  • Publication number: 20070248646
    Abstract: Provided are methods for alleviating a symptom of an eye condition by administering to a mammal an amount of azurocidin inhibitor effective to alleviate the symptom of the eye condition.
    Type: Application
    Filed: February 13, 2007
    Publication date: October 25, 2007
    Inventors: Ali Hafezi-Moghadam, Dimitra Skondra, Hyeong Yu, Kousuke Noda, Evangelos Gragoudas