Abstract: A method for preventing doxorubicin-induced cardiotoxicity is disclosed. The methods include administering a therapeutically effective amount of an inhibitor to brown adipose tissue signaling and expansion, including a SLIT2 inhibitor, as an adjuvant to the doxorubicin treatment. In one aspect, the method for preventing doxorubicin-induced cardiotoxicity includes administering a therapeutic amount of an anti-SLIT2 antibody.

Abstract: A method for preventing or reversing at least one of photoreceptor outer segment disruption. RPE lipid deposition, neurodegeneration, and any combination thereof in a patient in need is disclosed. The method includes administering a therapeutically effective amount of a composition comprising ApoM.

Abstract: Fusion protein nanodisk compositions and methods of treating a variety of disorders by administration of the fusion protein nanodisk compositions to a patient in need are disclosed. The fusion protein nanodisks provide for the combined delivery of two different apolipoproteins to a subject in need. Fusion protein nanodiscs may include a phospholipid bilayer encompassed by a fusion membrane scaffold protein. The fusion membrane scaffold protein may include two different amphipathic alpha-helical proteins, such as apolipoproteins. Methods for treating a disorder by administering a therapeutic amount of the fusion protein nanodisc described above are also disclosed.