Patents by Inventor Ali Khademhosseini

Ali Khademhosseini has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20190022280
    Abstract: The present invention provides compositions and methods for repair and reconstruction of defects and injuries to the cornea.
    Type: Application
    Filed: February 8, 2017
    Publication date: January 24, 2019
    Applicants: The Brigham and Women's Hospital, Inc., Massachusetts Eye and Ear Infirmary
    Inventors: Ali KHADEMHOSSEINI, Nasim ANNABI, Reza DANA, Ahmad KHEIRKHAH
  • Publication number: 20180111978
    Abstract: Disclosed herein are polypeptides comprising an amino acid sequence of {[VPGVG]4IPGVG}n, wherein n is an integer greater than 1. The polypeptides can be crosslinked to from biocompatible hydrogels with tunable and desirable mechanical properties. The polypeptides and hydrogels can be used in a variety of biomedical applications including treatment of bleeding, treatment of soft tissue injury, injectable filler, and tissue adhesives.
    Type: Application
    Filed: March 18, 2016
    Publication date: April 26, 2018
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Nasim ANNABI, Ali KHADEMHOSSEINI
  • Publication number: 20170232138
    Abstract: The present invention provides an improved tissue adhesive to repair defects in soft tissue. Following ASTM standard tests, crosslinked methacryloyl-substituted gelatin hydrogels of the present invention (GelSEAL) were shown to exhibit adhesive properties, i.e. wound closure strength, shear resistance and burst pressure, that were superior to clinically used fibrin- and poly(ethylene glycol)-based glues. Chronic in vivo experiments in rats proved GelSEAL to effectively seal large lung leakages without additional sutures or staples, presenting improved performance as compared to fibrin and poly(ethylene glycol) glues. Furthermore, subcutaneous implantation in rats revealed high biocompatibility of GelSEAL as evidenced by low inflammatory host response.
    Type: Application
    Filed: August 6, 2015
    Publication date: August 17, 2017
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Ali KHADEMHOSSEINI, Nasim ANNABI, Alexander ASSMANN
  • Patent number: 9688741
    Abstract: The present invention relates to hydrogels and to the use of hydrogels for repair or restoration of tissue. In particular, the hydrogels of the present invention can be used for the repair or restoration of cardiac tissue.
    Type: Grant
    Filed: October 23, 2013
    Date of Patent: June 27, 2017
    Assignees: Elastagen Pty Ltd, President and Fellows of Harvard College
    Inventors: Nasim Annabi, Anthony Steven Weiss, Ali Khademhosseini
  • Publication number: 20150274805
    Abstract: The present invention relates to hydrogels and to the use of hydrogels for repair or restoration of tissue. In particular, the hydrogels of the present invention can be used for the repair or restoration of cardiac tissue.
    Type: Application
    Filed: October 23, 2013
    Publication date: October 1, 2015
    Applicant: Elastagen Pty Ltd.
    Inventors: Nasim Annabi, Anthony Steven Weiss, Ali Khademhosseini
  • Publication number: 20110300570
    Abstract: The ability to rapidly generate concentration gradients of diffusible molecules has important applications in many chemical and biological studies. The present invention is directed to methods and systems for generating spatially and temporally controllable concentration gradients of molecules (i.e. proteins or toxins) in a portable microfluidic device. The formation of the concentration gradients can be initiated by an induced forward flow and further optimized during an induced backward flow. The forward and backward flows can be either passively induced and/or actively pumped. The centimeter-length gradients along the microfluidic channel can be spatially and temporally controlled by the backward flow. The gradient profile was stabilized by stopping the flow.
    Type: Application
    Filed: November 16, 2009
    Publication date: December 8, 2011
    Applicant: THE BRIGHAM AND WOMEN'S HOSPITAL, INC.
    Inventors: Ali Khademhosseini, Yanan Du, Matthew Hancock
  • Publication number: 20100112026
    Abstract: In various aspects, the present invention provides surfaces and materials for cell rolling applications, methods of making such surfaces and materials, and devices having such surfaces and materials. In some embodiments, the present invention provides surfaces with at least partial coatings of an ordered layer of cell adhesion molecules, or fragments, analogs, or modifications thereof, covalently bound to the surface of the substrate through an immobilization moiety. In some embodiments, the layer of a cell adhesion molecules further comprises a cell modifying ligand that can be targeted, e.g., to one or more specific cell types.
    Type: Application
    Filed: April 18, 2008
    Publication date: May 6, 2010
    Applicant: MASSACHUSETTS INSTITUTE TO TECHNOLOGY
    Inventors: Jeffrey M. Karp, Michael J. Moore, Ali Khademhosseini, Robert S. Langer, Seungpyo Hong
  • Publication number: 20080220169
    Abstract: A reuseable microfabrication stencil is described that can be reversibly sealed on various substrates to pattern biomolecules and biomaterials such as proteins and cells. The stencil may be used for the generation of both static and dynamic co-cultures, and cell aggregates. A multilayer stencil is described that can be used in biological patterning and used to create static and dynamic co-cultures and cell aggregates. Processes for producing and using the microfabrication stencils are also described.
    Type: Application
    Filed: October 16, 2007
    Publication date: September 11, 2008
    Applicant: The Brigham and Women's Hospital, Inc.
    Inventors: Ali Khademhosseini, Bimalraj Rajalingam
  • Publication number: 20080102276
    Abstract: A controlled release fabrication process includes shaping a precursor material into a desired configuration with a mold, supplying a curing agent from the mold to the precursor material, curing the precursor material to form a mechanically stable structure, and releasing the mechanically stable structure from the mold. Mechanically stable structures including microfabrication articles produced using the process are also described.
    Type: Application
    Filed: October 26, 2007
    Publication date: May 1, 2008
    Inventors: Ali Khademhosseini, Giovanni Franzesi, Bin Ni, Yibo Ling
  • Publication number: 20070042491
    Abstract: Culturing embryonic stem cells without the use of embryoid bodies leads to a increase in the frequency of predetermined cell types.
    Type: Application
    Filed: August 17, 2006
    Publication date: February 22, 2007
    Inventors: Jeffrey Karp, Lino Ferreira, Ali Khademhosseini, Robert Langer