Abstract: Systems, methods, and devices for treating vascular defects are disclosed herein. In some embodiments, a method of treating an aneurysm includes positioning a distal portion of an elongated member near or within an aneurysm. The method can include introducing an embolic composition into a lumen of the elongated member using an injector device coupled to a proximal portion of the elongated member. The injector device can pressurize the embolic composition to a pressure of at least 10,000 psi. The method can also include delivering the embolic composition into the aneurysm via the elongated member.

Abstract: Injectable biopolymer compositions and associated systems and methods are disclosed herein. In some embodiments, a biopolymer composition for treating an aneurysm is provided. The biopolymer composition can include an injectable hydrogel including: a biopolymer; a chemical crosslinker forming covalent bonds with the biopolymer; and a stabilizer configured to inhibit ex vivo precipitation of the biopolymer. The injectable hydrogel can have an ex vivo storage modulus of at least 100 Pa at 37° C. over a linear viscoelastic region of the injectable hydrogel. The ex vivo storage modulus can be greater than an ex vivo loss modulus of the injectable hydrogel over the linear viscoelastic region of the injectable hydrogel.