Abstract: The present disclosure provides systems and methods for controllable protein generation. According to some embodiments, the systems and methods leverage neural network models and techniques that have been developed for other fields, in particular, natural language processing (NLP). In some embodiments, the systems and methods use or employ models implemented with transformer architectures developed for language modeling and apply the same to generative modeling for protein engineering.

Abstract: An example method includes detecting, using sensors, packets throughout a datacenter. The sensors can then send packet logs to various collectors which can then identify and summarize data flows in the datacenter. The collectors can then send flow logs to an analytics module which can identify the status of the datacenter and detect an attack.

Abstract: An analytics system uses one or more machine-learned models to predict a hormone receptor status from a H&E stain image. The system partitions H&E stain images each into a plurality of non-overlapping image tiles. Bags of tiles are created through sampling of the image tiles. For each H&E stain image, the system generates a feature vector from a bag of tiles sampled from the partitioned image tiles. The analytics system trains one or more machine-learned models with training H&E stain images having a positive or negative receptor status. With the trained models, the analytics system predicts a hormone receptor status by applying a prediction model to the feature vector for a test H&E stain image.

Abstract: The present invention provides systems and methods for color tuning optical modules and executing color calibration methods on artificial reality systems and devices. Embodiments can include a lens with a colored coating, a plurality of cameras, including a visible spectrum camera and an infrared camera, each positioned behind the lens, and a processor and memory. The colored coating includes a plurality of regions for selectively transmitting light. The processor and memory can be configured to receive light information indicative of environmental information for executing an operation on the device, identify wavelengths of light reflected by the color profile in front of each camera, determine a color calibration to amplify wavelengths of reflected light, update the environmental information based on the color calibration, and execute the operation on the device.

Abstract: Mechanisms are provided to implement a machine learning training model. The machine learning training model trains an image generator of a generative adversarial network (GAN) to generate medical images approximating actual medical images. The machine learning training model augments a set of training medical images to include one or more generated medical images generated by the image generator of the GAN. The machine learning training model trains a machine learning model based on the augmented set of training medical images to identify anomalies in medical images. The trained machine learning model is applied to new medical image inputs to classify the medical images as having an anomaly or not.

Abstract: Embodiments are directed to finetuning a pre-trained language model using generative fitness finetuning. The generative fitness finetuning reuses a probability distribution learned during unsupervised training of the pre-trained language model to finetune and assay labeled data. The generative fitness finetuning trains the language model to classify a relative fitness of protein sequence pairs based on the corresponding probability of the protein sequences in the pairs. The generative fitness finetuning identifies protein sequences in the pairs with a higher probability as also having higher fitness. The trained and finetuned language model identifies fitness of a protein sequence.

Abstract: An analytics system uses one or more machine-learned models to predict a hormone receptor status from a H&E stain image. The system partitions H&E stain images each into a plurality of non-overlapping image tiles. Bags of tiles are created through sampling of the image tiles. For each H&E stain image, the system generates a feature vector from a bag of tiles sampled from the partitioned image tiles. The analytics system trains one or more machine-learned models with training H&E stain images having a positive or negative receptor status. With the trained models, the analytics system predicts a hormone receptor status by applying a prediction model to the feature vector for a test H&E stain image.

Abstract: Embodiments described herein provide methods and systems for generating data samples with enhanced attribute values. Some embodiments of the disclosure disclose a deep neural network framework with an encoder, a decoder, and a latent space therebetween, that is configured to extrapolate beyond the attributes of samples in a training distribution to generate data samples with enhanced attribute values by learning the latent space using a combination of contrastive objective, smoothing objective, cycle consistency objective, and a reconstruction loss.

Abstract: An analytics system uses one or more machine-learned models to predict a hormone receptor status from a H&E stain image. The system partitions H&E stain images each into a plurality of image tiles. Bags of tiles are created through sampling of the image tiles. The analytics system trains one or more machine-learned models with training H&E stain images having a positive or negative receptor status. The analytics system generates, via a tile featurization model, a tile feature vector for each image tile a test bag for a test H&E stain image. The analytics system generates, via an attention model, an aggregate feature vector for the test bag by aggregating the tile feature vectors of the test bag, wherein an attention weight is determined for each tile feature vector. The analytics system predicts a hormone receptor status by applying a prediction model to the aggregate feature vector for the test bag.

Abstract: The present disclosure relates to the development of methods for identifying cis-regulatory elements. Also disclosed herein are various methods including for example determining the tissue of origin of a biological sample, prognosis of a patient diagnosed with a cancer and their response to treatments.

Abstract: Embodiments described herein provide an alignment-based pre-training mechanism for protein prediction. Specifically, the protein prediction model takes as input features derived from multiple sequence alignments (MSAs), which cluster proteins with related sequences. Features derived from MSAs, such as position specific scoring matrices and hidden Markov model (HMM) profiles, have long known to be useful features for predicting the structure of a protein. Thus, in order to predict profiles derived from MSAs from a single protein in the alignment, the neural network learns information about that protein's structure using HMM profiles derived from MSAs as labels during pre-training (rather than as input features in a downstream task).

Abstract: Mechanisms are provided to implement a machine learning training model. The machine learning training model trains an image generator of a generative adversarial network (GAN) to generate medical images approximating actual medical images. The machine learning training model augments a set of training medical images to include one or more generated medical images generated by the image generator of the GAN. The machine learning training model trains a machine learning model based on the augmented set of training medical images to identify anomalies in medical images. The trained machine learning model is applied to new medical image inputs to classify the medical images as having an anomaly or not.

Abstract: An analytics system uses one or more machine-learned models to predict a hormone receptor status from a H&E stain image. The system partitions H&E stain images each into a plurality of image tiles. Bags of tiles are created through sampling of the image tiles. The analytics system trains one or more machine-learned models with training H&E stain images having a positive or negative receptor status. The analytics system generates, via a tile featurization model, a tile feature vector for each image tile a test bag for a test H&E stain image. The analytics system generates, via an attention model, an aggregate feature vector for the test bag by aggregating the tile feature vectors of the test bag, wherein an attention weight is determined for each tile feature vector. The analytics system predicts a hormone receptor status by applying a prediction model to the aggregate feature vector for the test bag.

Abstract: The present disclosure provides systems and methods for controllable protein generation. According to some embodiments, the systems and methods leverage neural network models and techniques that have been developed for other fields, in particular, natural language processing (NLP). In some embodiments, the systems and methods use or employ models implemented with transformer architectures developed for language modeling and apply the same to generative modeling for protein engineering.

Abstract: The present disclosure provides systems and methods for controllable protein generation. According to some embodiments, the systems and methods leverage neural network models and techniques that have been developed for other fields, in particular, natural language processing (NLP). In some embodiments, the systems and methods use or employ models implemented with transformer architectures developed for language modeling and apply the same to generative modeling for protein engineering.

Abstract: The present disclosure provides systems and methods for controllable protein generation. According to some embodiments, the systems and methods leverage neural network models and techniques that have been developed for other fields, in particular, natural language processing (NLP). In some embodiments, the systems and methods use or employ models implemented with transformer architectures developed for language modeling and apply the same to generative modeling for protein engineering.

Abstract: Mechanisms are provided to implement a generative adversarial network (GAN). A discriminator of the GAN is configured to discriminate input medical images into a plurality of classes including a first class indicating a medical image representing a normal medical condition, a second class indicating an abnormal medical condition, and a third class indicating a generated medical image. A generator of the GAN generates medical images and a training medical image set is input to the discriminator that includes labeled medical images, unlabeled medical images, and generated medical images. The discriminator is trained to classify training medical images in the training medical image set into corresponding ones of the first, second, and third classes. The trained discriminator is applied to a new medical image to classify the new medical image into a corresponding one of the first class or second class. The new medical image is either labeled or unlabeled.

Abstract: Mechanisms are provided to implement a neural network, a concept extractor, and a machine learning model that operate to provide automatic contour annotation of medical images based on correlations with medical reports. The neural network processes a medical image to extract image features of the medical image. The concept extractor processes a portion of text associated with the medical image to extract concepts associated with the portion of text. The machine learning model correlates the extracted image features with the extracted concepts. An annotated medical image is generated based on the correlation of the extracted image features and extracted concepts. An annotation of the annotated medical image specifies a region of interest corresponding to both an extracted image feature and an extracted concept, thereby automatically mapping the portion of text to a relevant region of the medical image.

Abstract: Mechanisms are provided to implement a machine learning training model. The machine learning training model trains an image generator of a generative adversarial network (GAN) to generate medical images approximating actual medical images. The machine learning training model augments a set of training medical images to include one or more generated medical images generated by the image generator of the GAN. The machine learning training model trains a machine learning model based on the augmented set of training medical images to identify anomalies in medical images. The trained machine learning model is applied to new medical image inputs to classify the medical images as having an anomaly or not.

Abstract: Mechanisms are provided to implement a machine learning training model. The machine learning training model trains an image generator of a generative adversarial network (GAN) to generate medical images approximating actual medical images. The machine learning training model augments a set of training medical images to include one or more generated medical images generated by the image generator of the GAN. The machine learning training model trains a machine learning model based on the augmented set of training medical images to identify anomalies in medical images. The trained machine learning model is applied to new medical image inputs to classify the medical images as having an anomaly or not.