Abstract: A differential all-pass coupling circuit with common mode feedback is disclosed. An example apparatus includes an anti-aliasing circuit configured to reduce a bandwidth of a first differential signal, and a switched-capacitor circuit coupled to the anti-aliasing circuit configured to control a first switch to charge a capacitor to a first voltage based on a first difference between (i) a common mode input voltage associated with a first common mode voltage of the first differential signal and (ii) a common mode reference voltage associated with a second common mode voltage of an input stage of the receiver, control a second switch to provide a second voltage to the capacitor based on a second difference between the first differential signal and the common mode input voltage, and output a second differential signal to the input stage based on the first differential signal adjusted by the second voltage.

Abstract: Described herein is a technique to facilitate filtering during candidate retrieval stage performed by an information retrieval system that utilizes embedding models. An aNN indexing structure is created for each end-user, and in some instances, each activity type. This allows a single request for candidate content items to invoke a single process to obtain content items that satisfy the filtering criteria (e.g., in this case, the in-network requirement) from the separate per-end-user indexes.

Abstract: Described herein is a technique to facilitate filtering during candidate retrieval stage performed by an information retrieval system that utilizes embedding models. An aNN indexing structure is created for each end-user, and in some instances, each activity type. This allows a single request for candidate content items to invoke a single process to obtain content items that satisfy the filtering criteria (e.g., in this case, the in-network requirement) from the separate per-end-user indexes.

Abstract: A device for enhancing mandibular bone growth can include left and right head modules, a headband linking the left and right head modules and supporting the head modules, at least one transmitter circuit fixed to respective left and right head modules, left and right electrodes configured for receiving the transmitted electromagnetic field, and left and right transmitter antenna rods fixed to the left and right electrodes for receiving signals from the transmitter. The transmitter circuit can include a power supply, a driver, and at least one transmitter capable of transmitting an electromagnetic field for transmission to the patient's mandible.

Abstract: Embodiments of the present disclosure include a structure with a substrate, an electronic device, and a molding compound layer. The substrate has a first surface and a second surface opposite to the first surface, where the substrate includes a first opening. The electronic device is disposed on the first surface of the substrate and includes a second opening aligned with the first opening of the substrate. Further, the molding compound layer is disposed on the second surface of the substrate and includes a third opening aligned with the second opening of the electronic device.

Abstract: Provided is a chimeric target factor receptor capable of activating an antigen-presenting cell such as a dendritic cell in a target-factor-specific manner. The chimeric target factor receptor contains a target factor-binding domain, a transmembrane domain, and an intracellular domain containing a TLR intracellular domain.

Abstract: The disclosure relates to systems and methods in which aliphatic epoxy resin crosslinked polymers are used in primary cementing applications. The aliphatic epoxy resin crosslinked polymers contain a derivative of a first epoxy resin, a derivative of a second epoxy resin and a polyamine. The first epoxy resin contains bisphenol A and an aliphatic monoglycidyl ether. The second epoxy resin contains a C12-C14 alkyl glycidyl ether.

Abstract: The present invention provides a mutated woodchuck post-transcriptional regulatory element (WPRE). In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest to a target cell.

Abstract: The disclosure relates to compounds of Formula I, methods of making same, pharmaceutical compositions including same, and methods of treating pain and neurological disorders using same: wherein R1 is hydrogen, halogen, hydroxy, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, aryl, nitro, or cyano; wherein R2 and R3 are independently hydrogen, halogen, aryl, or substituted or unsubstituted alkyl, or wherein R2 and R3 are connected to form an alkyl chain; wherein R4 is a substituted or unsubstituted aryl or heteroaryl group having from 5 to 10 members; wherein X is O, S, N, NH, CH, CH2, or CO; wherein n is from 0 to 10; and wherein the bond indicated by * is a double bond or a single bond based on a valence of X. The compounds selectively bind to CB2, can penetrate the blood brain barrier, and have a half-life of 20 hours or greater.

Abstract: A method for assembling an uncured spoke is provided. The method includes the assembly of a panel (14), a first foot (24), and a second foot (26) of the uncured spoke. The first foot (24) and the second foot (26) are complexed onto the panel (14), and the panel extends continuously from the first foot to the second foot.

Abstract: The disclosure relates to methods of manufacturing T cells for adoptive immunotherapy. The disclosure further provides for methods of genetically transducing T cells, methods of using T cells, and T cell populations thereof. In an aspect, the disclosure provides for methods of thawing frozen peripheral blood mononuclear cells (PBMC), resting the thawed PBMC, activating the T cell in the cultured PBMC with an anti-CD3 antibody and an anti-CD28 antibody immobilized on a solid phase, transducing the activated T cell with a viral vector, expanding the transduced T cell, and obtaining expanded T cells.

Abstract: An in vitro method of expanding ?? T cells includes isolating ?? T cells from a blood sample of a human subject, activating the isolated ?? T cells in the presence of an aminobisphosphonate and/or a feeder cell and at least one cytokine, expanding the activated ?? T cells, and optionally restimulating the expanded ?? T cells.

Abstract: Methods, systems, and computer programs are presented for reducing latency for providing a user feed containing one or more posts. One method includes operations for receiving a request to access the user feed and for performing a first query to search posts. The first query uses a first time horizon delimiting a creation time of posts and a first maximum number of posts selected for ranking. The posts from the first query are sent to the client device for presentation on a user interface. Further, a second query is performed to search posts, where the second query uses a second time horizon that is greater than the first time horizon and a second maximum number of posts for ranking that is greater than the first maximum number of posts. The posts from the first query and the second query are merged and sent to the client device for presentation.

Abstract: A method of producing an engineered T cell population includes obtaining a cell population comprising a CD8+ T cell, isolating the CD8+ T cell from the obtained cell population, activating the isolated CD8+ T cell, introducing a nucleic acid encoding a T cell receptor (TCR) binding to an antigen in a complex with an MHC molecule into the activated CD8+ T cell, and expanding the introduced CD8+ T cell to obtain the engineered T cell population.

Abstract: A method for assembling an uncured spoke is provided. The method includes the assembly of a panel (14), a first foot (24), and a second foot (26) of the uncured spoke. The first foot (24) and the second foot (26) are complexed onto the panel (14), and the panel extends continuously from the first foot to the second foot.

Abstract: The present invention provides a mutated woodchuck post-transcriptional regulatory element (WPRE). In particular, the present invention relates to a mutated WPRE sequence that can efficiently express nucleotides of interest in a retroviral vector system. The present invention also relates to methods of delivering and expressing nucleotides of interest to a target cell.

Abstract: Methods, systems, and computer programs are presented for reducing latency for providing a user feed containing one or more posts. One method includes operations for receiving a request to access the user feed and for performing a first query to search posts. The first query uses a first time horizon delimiting a creation time of posts and a first maximum number of posts selected for ranking. The posts from the first query are sent to the client device for presentation on a user interface. Further, a second query is performed to search posts, where the second query uses a second time horizon that is greater than the first time horizon and a second maximum number of posts for ranking that is greater than the first maximum number of posts. The posts from the first query and the second query are merged and sent to the client device for presentation.

Abstract: The present disclosure describes a method and system for linearizing an amplifier using transistor-level dynamic feedback. The method and system enables nonlinear amplifiers to exhibit linear performance using one or more of gain control elements and phase shifters in the feedback path. The disclosed method and system may also allow an amplifier to act as a pre-distorter or a frequency/gain programmable amplifier.

Abstract: The disclosure relates to methods of manufacturing T cells for adoptive immunotherapy. The disclosure further provides for methods of genetically transducing T cells, methods of using T cells, and T cell populations thereof. In an aspect, the disclosure provides for methods of thawing frozen peripheral blood mononuclear cells (PBMC), resting the thawed PBMC, activating the T cell in the cultured PBMC with an anti-CD3 antibody and an anti-CD28 antibody immobilized on a solid phase, transducing the activated T cell with a viral vector, expanding the transduced T cell, and obtaining expanded T cells.

Abstract: Described herein are methods for preparing T cells, including isolating CD8+ T cells from a blood sample obtained from a patient or a donor, culturing the isolated CD8+ T cells in the presence of at least one cytokine, contacting the cultured CD8+ T cells with a multimer containing a target peptide in a complex with an MHC molecule and with at least one binding agent that binds to a T cell surface molecule, in which the multimer is labelled with a first detectable agent and the binding agent is labelled with a second detectable agent, sorting the contacted CD8+ T cells to collect the sorted CD8+ T cells that are detected positive for the first and the second detectable agents, and expanding the collected CD8+ T cells.