Abstract: The present invention relates to nucleic acid molecules for use in the treatment or prevention of disease.

Abstract: The present invention provides novel nucleic acid compound suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.

Abstract: The present invention relates to inhibitors, and compositions containing inhibitors, and uses of the same in the treatment or prevention of diabetes.

Abstract: The present invention relates to novel conjugated oligonucleotide compounds, which are suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.

Abstract: The present invention relates to nucleic acid molecules for use in the treatment or prevention of disease.

Abstract: The present invention provides novel conjugated oligonucleotide compounds, which are suitable for therapeutic use. Additionally, the present invention provides methods of making these compounds, as well as methods of using such compounds for the treatment of various diseases and conditions.

Abstract: Batch routing of autonomous vehicles is disclosed. A method may include maintaining a plurality of vehicle state data object instances that respectively correspond to a plurality of autonomous vehicles. The method includes obtaining a traffic condition location and determining a group of autonomous vehicles from the plurality of autonomous vehicles where the current route of each autonomous vehicle intersects the traffic condition location. The method also includes determining two or more subgroups of autonomous vehicles, and for each subgroup, determining a respective avoidance waypoint corresponding to the subgroup that is not on the current route of the autonomous vehicle. For each autonomous vehicle in the subgroup, the method includes determining an updated route based on the current route of the autonomous vehicle and the respective avoidance waypoint, generating a control instruction based on the updated route, and transmitting the control instruction to the autonomous vehicle.

Abstract: Methods and systems for controlling a vehicle are herein disclosed. A method includes receiving vehicle data and external data from a vehicle control system of a vehicle and generating an environment representation of an area of the transportation network proximate to the vehicle location. The method includes displaying the environment representation in a GUI and receiving a solution path via the graphical user interface, the solution path indicating a route and one or more stop points. The method includes transmitting the route to the vehicle including a respective geolocation of each of the one or more stop points. The vehicle receives the route and begins traversing the transportation network based on the solution path. The method includes receiving updated vehicle data and/or updated external data from the vehicle and updating the environment representation based thereon. The method includes displaying, the updated environment representation via the graphical user interface.

Abstract: A remote system for an autonomous vehicle, includes a receiver, a controller, and a display device. The receiver is configured to receive road information. The controller is programmed to receive input related to the road information and create a supervision zone when the road information impacts road drivability. The display device is disposed at a control center area and configured to display a visual indication on a map of the supervision zone.

Abstract: An autonomous vehicle service system having a display device, a receiver, and a controller. The receiver is configured to receive transmitted data from an autonomous vehicle related to status of the autonomous vehicle and information from a third party related to road conditions. The controller is programmed to monitor the transmitted data related to the status of the autonomous vehicle and the road conditions, determine when the autonomous vehicle requires assistance based on the transmitted data, and, when the autonomous vehicle requires assistance, cause information related to the autonomous vehicle to be displayed on the display device.

Abstract: An autonomous vehicle service system having a display device, a receiver, and a controller. The receiver is remote from an autonomous vehicle and configured to receive transmitted data from a third party and the autonomous vehicle. The controller is configured to monitor the transmitted data related to the status of the autonomous vehicle, and cause information related to the autonomous vehicle to be displayed on the display device, the controller further configured to enable the autonomous vehicle service system to be accessed by the third party so as to be capable of forming and updating a supervision zone to restrict access to an area by the autonomous vehicle.

Abstract: A method for world objects tracking and prediction by an autonomous vehicle includes receiving, from sensors of the AV, a first observation data; associating the first observation data with a first world object; determining hypotheses for the first world object; determining a respective hypothesis likelihood of each of the hypotheses indicating a likelihood that the first world object follows the intention; determining, for at least one hypothesis of the hypotheses, a respective state; and in response to a query, providing a hypothesis of the hypotheses based on the respective hypothesis likelihood of each of the hypotheses. A hypothesis corresponds to an intention of the first world object and the respective state includes predicted positions of the first world object.

Abstract: Exception handing, such as of obstruction situations, by an autonomous vehicle (AV) is disclosed. A method includes identifying an exception situation; identifying a risk associated with autonomously resolving the exception situation; and in response to the risk exceeding a risk threshold, initiating a request for assistance from a tele-operator, and halting for the tele-operator to respond to the request; and receiving a response from the tele-operator.

Abstract: According to some implementations of the present disclosure, a method for controlling an autonomous vehicle is disclosed. The method includes traversing the transportation network in accordance with a route and receiving vehicle sensor data from one or more vehicle sensors of the autonomous vehicle. The method also includes determining that the autonomous vehicle has encountered an occlusion scenario based on the vehicle sensor data. In response to determining that the autonomous vehicle has encountered the occlusion scenario, the method includes transmitting a request for infrastructure data to an external resource via a communication network, receiving infrastructure data from the external resource, determining a control action for the autonomous vehicle to perform based on the infrastructure data and the vehicle sensor data, and controlling the autonomous vehicle based on the control action.

Abstract: Batch routing of autonomous vehicles is disclosed. A method may include maintaining a plurality of vehicle state data object instances that respectively correspond to a plurality of autonomous vehicles. The method includes obtaining a traffic condition location and determining a group of autonomous vehicles from the plurality of autonomous vehicles where the current route of each autonomous vehicle intersects the traffic condition location. The method also includes determining two or more subgroups of autonomous In vehicles, and for each subgroup, determining a respective avoidance waypoint corresponding to the subgroup that is not on the current route of the autonomous vehicle. For each autonomous vehicle in the subgroup, the method includes determining an updated route based on the current route of the autonomous vehicle and the respective avoidance waypoint, generating a control instruction based on the updated route, and transmitting the control instruction to the autonomous vehicle.

Abstract: World objects tracking and prediction by an autonomous vehicle is disclosed. A method includes receiving, from sensors of the AV, a first observation data; associating the first observation data with a first world object; determining hypotheses for the first world object, wherein a hypothesis corresponds to an intention of the first world object; determining a respective hypothesis likelihood of each of the hypotheses indicating a likelihood that the first world object follows the intention; determining, for at least one hypothesis of the hypotheses, a respective state, wherein the respective state comprises predicted positions of the first world object; and in response to a query, providing a hypothesis of the hypotheses based on the respective hypothesis likelihood of each of the hypotheses.

Abstract: According to some implementations of the present disclosure, a method for controlling an autonomous vehicle is disclosed. The method includes traversing the transportation network in accordance with a route and receiving vehicle sensor data from one or more vehicle sensors of the autonomous vehicle. The method also includes determining that the autonomous vehicle has encountered an occlusion scenario based on the vehicle sensor data. In response to determining that the autonomous vehicle has encountered the occlusion scenario, the method includes transmitting a request for infrastructure data to an external resource via a communication network, receiving infrastructure data from the external resource, determining a control action for the autonomous vehicle to perform based on the infrastructure data and the vehicle sensor data, and controlling the autonomous vehicle based on the control action.

Abstract: Exception handing, such as of obstruction situations, by an autonomous vehicle (AV) is disclosed. A method includes identifying an exception situation; identifying a risk associated with autonomously resolving the exception situation; and in response to the risk exceeding a risk threshold, initiating a request for assistance from a tele-operator, and halting for the tele-operator to respond to the request; and receiving a response from the tele-operator.

Abstract: Methods and systems for controlling a vehicle are herein disclosed. A method includes receiving vehicle data and external data from a vehicle control system of a vehicle and generating an environment representation of an area of the transportation network proximate to the vehicle location. The method includes displaying the environment representation in a GUI and receiving a solution path via the graphical user interface, the solution path indicating a route and one or more stop points. The method includes transmitting the route to the vehicle including a respective geolocation of each of the one or more stop points. The vehicle receives the route and begins traversing the transportation network based on the solution path. The method includes receiving updated vehicle data and/or updated external data from the vehicle and updating the environment representation based thereon. The method includes displaying, the updated environment representation via the graphical user interface.

Abstract: Disclosed herein is a system for simulating depletion/injection processes under true triaxial stress conditions. The system may include a pressure cell coupled with a true triaxial loading mechanism. A cubical rock specimen may be disposed within the pressure cell and vertical and horizontal loading mechanisms of the true triaxial loading mechanism may compress the cubical rock specimen along three principle axes, while pore pressure within the cubical rock specimen may be increased or decreased by injecting or discharging a pressurized fluid within the pressure cell in order to simulate in situ conditions of a real reservoir.