Patents by Inventor Ali MOTAZEDIAN

Ali MOTAZEDIAN has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS FOR PRODUCING LYMPHOCYTE PROGENITORS
    Publication number: 20200399390
    Abstract: The invention relates to a method for producing a lymphocyte progenitor, the method comprising culturing a pluripotent stem cell (PSC)-derived CD34+ cell at an air-liquid interface (ALI). The invention also relates to a method for producing a B-cell progenitor, the method comprising co-culturing a PSC-derived CD34+ cell and a stromal cell in a medium comprising a CD117 activator and a NOTCH1 inhibitor. The invention further relates to a T-cell progenitor and a B-cell progenitor when produced by the methods of the invention and to use of the T-cell progenitor in the manufacture of T cell with defined antigen specificity, optionally a chimeric antigen receptor (CAR) T cell, and use of the B-cell progenitor in the manufacture of an antibody.
    Type: Application
    Filed: March 8, 2018
    Publication date: December 24, 2020
    Applicant: MURDOCH CHILDRENS RESEARCH INSTITUTE
    Inventors: Edouard Guy STANLEY, Andrew ELEFANTY, Ali MOTAZEDIAN