Abstract: Methods, systems, and apparatus, including computer programs encoded on a computer storage medium, for performing protein design. In one aspect, a method comprises: processing an input characterizing a target protein structure of a target protein using an embedding neural network having a plurality of embedding neural network parameters to generate an embedding of the target protein structure of the target protein; determining a predicted amino acid sequence of the target protein based on the embedding of the target protein structure, comprising: conditioning a generative neural network having a plurality of generative neural network parameters on the embedding of the target protein structure; and generating, by the generative neural network conditioned on the embedding of the target protein structure, a representation of the predicted amino acid sequence of the target protein.

Abstract: A stabilized active oxygen-generating antiseptic composition is disclosed including at least one of an antiseptic mixture or an antiseptic polymer. The antiseptic mixture includes a persulfate distributed in a matrix of a sulfate wherein the antiseptic composition is characterized by a ratio of the sulfate to the persulfate of at least 8:2. The antiseptic polymer is formed by the reaction of a sulfate, a persulfate, and amino acid in a reaction solution having a ratio of the sulfate to the persulfate of at least 6:4 and a ratio of the amino acid to the sulfate and the persulfate combined of 1:2 to 2:1. An antiseptic irrigation solution is disclosed including the antiseptic composition dispersed in a solvent. An antiseptic article is disclosed including an article and at least one of the antiseptic composition or an antiseptic coating formed from the antiseptic composition disposed on a surface of the article.

Abstract: A variational autoencoder (VAE) neural network system, comprising an encoder neural network to encode an input data item to define a posterior distribution for a set of latent variables, and a decoder neural network to generate an output data item representing values of a set of latent variables sampled from the posterior distribution. The system is configured for training with an objective function including a term dependent on a difference between the posterior distribution and a prior distribution. The prior and posterior distributions are arranged so that they cannot be matched to one another. The VAE system may be used for compressing and decompressing data.

Abstract: A stabilized active oxygen-generating antiseptic composition is disclosed including at least one of an antiseptic mixture or an antiseptic polymer. The antiseptic mixture includes a persulfate distributed in a matrix of a sulfate wherein the antiseptic composition is characterized by a ratio of the sulfate to the persulfate of at least 8:2. The antiseptic polymer is formed by the reaction of a sulfate, a persulfate, and amino acid in a reaction solution having a ratio of the sulfate to the persulfate of at least 6:4 and a ratio of the amino acid to the sulfate and the persulfate combined of 1:2 to 2:1. An antiseptic irrigation solution is disclosed including the antiseptic composition dispersed in a solvent. An antiseptic article is disclosed including an article and at least one of the antiseptic composition or an antiseptic coating formed from the antiseptic composition disposed on a surface of the article.

Abstract: A stabilized active oxygen-generating antiseptic composition is disclosed including at least one of an antiseptic mixture or an antiseptic polymer. The antiseptic mixture includes a persulfate distributed in a matrix of a sulfate wherein the antiseptic composition is characterized by a ratio of the sulfate to the persulfate of at least 8:2. The antiseptic polymer is formed by the reaction of a sulfate, a persulfate, and amino acid in a reaction solution having a ratio of the sulfate to the persulfate of at least 6:4 and a ratio of the amino acid to the sulfate and the persulfate combined of 1:2 to 2:1. An antiseptic irrigation solution is disclosed including the antiseptic composition dispersed in a solvent. An antiseptic article is disclosed including an article and at least one of the antiseptic composition or an antiseptic coating formed from the antiseptic composition disposed on a surface of the article.

Abstract: A variational autoencoder (VAE) neural network system, comprising an encoder neural network to encode an input data item to define a posterior distribution for a set of latent variables, and a decoder neural network to generate an output data item representing values of a set of latent variables sampled from the posterior distribution. The system is configured for training with an objective function including a term dependent on a difference between the posterior distribution and a prior distribution. The prior and posterior distributions are arranged so that they cannot be matched to one another. The VAE system may be used for compressing and decompressing data.

Abstract: A variational autoencoder (VAE) neural network system, comprising an encoder neural network to encode an input data item to define a posterior distribution for a set of latent variables, and a decoder neural network to generate an output data item representing values of a set of latent variables sampled from the posterior distribution. The system is configured for training with an objective function including a term dependent on a difference between the posterior distribution and a prior distribution. The prior and posterior distributions are arranged so that they cannot be matched to one another. The VAE system may be used for compressing and decompressing data.

Abstract: A variational autoencoder (VAE) neural network system, comprising an encoder neural network to encode an input data item to define a posterior distribution for a set of latent variables, and a decoder neural network to generate an output data item representing values of a set of latent variables sampled from the posterior distribution. The system is configured for training with an objective function including a term dependent on a difference between the posterior distribution and a prior distribution. The prior and posterior distributions are arranged so that they cannot be matched to one another. The VAE system may be used for compressing and decompressing data.

Abstract: Example implementations relate to PRNU suppression. For example, PRNU suppression may include performing a calibration surface PRNU characterization using a scanning system, performing a document-based PRNU characterization using the scanning system, and determining a correction function for PRNU suppression for the scanning system based on the calibration surface PRNU characterization and the document-based PRNU characterization.

Abstract: Example implementations relate to PRNU suppression. For example, PRNU suppression may include performing a calibration surface PRNU characterization using a scanning system, performing a document-based PRNU characterization using the scanning system, and determining a correction function for PRNU suppression for the scanning system based on the calibration surface PRNU characterization and the document-based PRNU characterization.

Abstract: A drug delivery composition is disclosed which includes a triple salt proxy functional group and at least one amino acid functional group. A method of forming the drug delivery composition includes reacting a triple salt with at least one amino acid in an aqueous environment. A biodegradable fabric is disclosed which includes a polymerized structure of a triple salt proxy functional group and at least one amino acid functional group.

Abstract: A drug delivery composition is disclosed which includes a triple salt proxy functional group and at least one amino acid functional group. A method of forming the drug delivery composition includes reacting a triple salt with at least one amino acid in an aqueous environment. A biodegradable fabric is disclosed which includes a polymerized structure of a triple salt proxy functional group and at least one amino acid functional group.

Abstract: An illumination source comprises a plurality of groups of serially-coupled light emitting diodes (LEDs). The LEDs in each group have an emission-spectrum that is common to that group. At least one group has a different emission-spectrum from at least one other group and at least one group of LEDs has a different number of LEDs than at least one other group.

Abstract: An illumination source for a scanner comprises a plurality of terminals and a plurality of light emitting diodes (LEDs) with at least two LEDs having different wavelengths. Each LED is coupled to a terminal and each LED is capable of being turned on and off via a signal provided to a terminal to which that LED is coupled. The number of LEDs is greater than the number of terminals.

Abstract: The present invention is directed to attaching drugs 11 and other functional groups to surfaces of nano-sized diamond particles (NDs) 20 to enhance their efficacy. The method involves hydrating a plurality of nanodiamond (ND) particles 20 having a plurality of carbon chain surface molecules 23 on its surface. Cations 40 are embedded within the lattice structure 21 of the surface molecules 23 of the ND particles 20. The embedded cations 40 attract anions that cause crystalline growth. The anion form of drug molecules 11 are then grown on the crystal to cause the NDs 20 to be coated such that the active sites of said drug molecules 11 point away from the ND particle 20 exposing them for enhanced activity and enhanced drug efficacy. The efficacy of antimicrobial drugs 11, as well as other drugs 11 are enhanced by their attachment to the NDs 20.

Abstract: Drugs 11 and other functional groups are attached to surfaces of nano-sized diamonds (NDs) 20 to enhance the efficacy of drugs 11 such as analgesics, cholesterol-reducing drugs and other substances. Such coatings are formed by covalently linking NDs to the drug 11. NDs 20, due to its small size and spherical shape exhibits a large surface area which enhances contact with other substances and therefore the chemical reactions. The large surface area of NDs 20 covered with active drugs allows greater access to active sites of the drugs and allows a large amount of substance to come in contact with other chemical entities enhancing the reactions. NDs 20 are also a solution stabilizer allowing enhanced concentration and solubility of coated NDs 20, enhancing the ability of the active sites of drugs 11 to be dissolved and come in contact with corresponding sites 13,15 of other entities enhancing their efficacy.

Abstract: The present invention is directed to attaching drugs and other functional groups to surfaces of nano-sized diamonds (NDs) to enhance the efficacy of drugs and other substances. The method involved enhancing the efficacy of a drug having an active site by acquiring a plurality of nanodiamond (ND) particles having a plurality of carbon chain surface molecules on its surface. Intermediate amine entities are covalently attached to the surface molecules of the ND particles. These are then replaces with said drug molecules such that the active sites of said drug molecules point away from the ND particle exposing them for enhanced activity and enhanced drug efficacy. The efficacy of antimicrobial drugs are enhanced, however, this may be used with many different types of drugs.

Abstract: An absorbent article (1000) includes “beads” (111) that are modified to add functional groups (113). The functional groups (113) add antimicrobial, fire retardant, alcohol repellant and other properties. In addition, the beads (111) may be inert diamond, or conductive graphite. The substrate (101) of the article (1000) may be made with the beads (111) and functional groups (113) retaining the properties. The beads (111) and functional groups (113) may be incorporated into super absorbent materials (117) and attached to the substrate (101), with or without a binder (103). The resulting article (1000) therefore may have antimicrobial, fire retardant, alcohol repellant and antistatic properties making it specifically useful in medical applications. It may also be made as a multi-layered article (1000) having different amounts of super absorbent (“SA”) particles (1207, 1307, 1407) printed or embedded in patterns on each layer (1100, 1200, 1300, 1400), thereby channeling liquids.

Abstract: An imaging device illumination system comprises an elongate light pipe configured to receive light from a light source and propagate the light therethrough, and a diffusive reflector disposed about at least a portion of the light pipe and configured to direct light from the light pipe toward an object to be imaged.

Abstract: A novel method of designing and fabricating flexible and lightweight cable [100] having a central conductor [110], a dielectric layer [130], an outer conductor [150] and an insulation coating [170] using thin film technology is disclosed. The dielectric layer [130] is ‘grown’ on dielectric layer [130] using electrophoretic deposition to a specified thickness, based upon its intended use. It may include nano-diamonds. Ion beam assisted deposition is used to metalize the cable dielectric layer [130]. This may be ion beam assisted sputtering, ion beam assisted evaporative deposition or ion beam assisted cathodic arc deposition. In an alternative embodiment, the outer conductor may be etched to provide greater flexibility, or to add a piezoelectric layer. The central conductor [110] may be created from dielectric fibers [113] which are metalized as described above. The piezoelectric layer added to create ultrasonic transducer cables.