Abstract: The present invention relates to inhibitors of HIF-1 and HIF-2 and uses thereof. The present invention further relates to the inhibitors for use in treatment of diseases. An isolated polypeptide is provided, that prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and/or inhibits the activity of HIF-1 and HIF-2, wherein the polypeptide comprises the amino acid sequence C-X1-X2-X3-Z-X4 (SEQ ID NO: 1) and wherein X1, X2, X3 and X4 are any amino acid and wherein Z is leucine, valine of isoleucine or a non-natural derivative or leucine, valine or isoleucine. The isolated polypeptide prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and inhibits the activity of HIF-1 and HIF-2 by binding to HIF-1? or HIF-1? and/or HIF-2? or HIF-1?.

Abstract: The present invention relates to inhibitors of HIF-1 and HIF-2 and uses thereof. The present invention further relates to the inhibitors for use in treatment of diseases. An isolated polypeptide is provided, that prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and/or inhibits the activity of HIF-1 and HIF-2, wherein the polypeptide comprises the amino acid sequence C-X1-X2-X3-Z-X4 (SEQ ID NO: 1) and wherein X1, X2, X3 and X4 are any amino acid and wherein Z is leucine, valine of isoleucine or a non-natural derivative or leucine, valine or isoleucine. The isolated polypeptide prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and inhibits the activity of HIF-1 and HIF-2 by binding to HIF-1? or HIF-1? and/or HIF-2? or HIF-1?.

Abstract: The present invention relates to inhibitors of HIF-1 and HIF-2 and uses thereof. The present invention further relates to the inhibitors for use in treatment of diseases. An isolated polypeptide is provided, that prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and/or inhibits the activity of HIF-1 and HIF-2, wherein the polypeptide comprises the amino acid sequence C-X1-X2-X3-Z-X4 (SEQ ID NO 1) and wherein X1, X2, X3 and X4 are any amino acid and wherein Z is leucine, valine of isoleucine or a non-natural derivative or leucine, valine or isoleucine. The isolated polypeptide prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and inhibits the activity of HIF-1 and HIF-2 by binding to HIF-1? or HIF-1? and/or HIF-2? or HIF-1?.

Abstract: A method for co-compartmentalising a cyclic polypeptide with a polynucleotide encoding the cyclic polypeptide, comprising the steps of a) forming a compartment containing a polynucleotide encoding the cyclic polypeptide, b) expressing a polypeptide from the polynucleotide, and c) cyclising the polypeptide. Co-compartmentalised cyclic polypeptides and encoding polynucleotides. Libraries of co-compartmentalised cyclic polypeptide and encoding polynucleotide. Methods for screening libraries of co-compartmentalised cyclic polypeptide and encoding polynucleotide. Incorporation of non-canonical nucleic acids into such libraries.

Abstract: Disclosed herein are methods of synthesising a double stranded polynucleotide, the methods including providing a set of self-templating oligonucleotides wherein the set of self-templating oligonucleotides encodes a double stranded polynucleotide sequence of interest; annealing the oligonucleotides together so that they form the double stranded polynucleotide sequence with the oligonucleotides in the correct order and adjacent oligonucleotides in the same strand close enough to each other that a covalent bond could form between the 5? end of one oligonucleotide and the 3? end of an adjacent oligonucleotide; and covalently bonding the backbones of adjacent oligonucleotides in the same strand to each other so that a covalent bond is formed between the 5?end of an oligonucleotide to the 3?end of the adjacent oligonucleotide to provide the double stranded polynucleotide of interest, wherein the covalent bonds between adjacent oligonucleotides can be read-through accurately by a DNA polymerase or an RNA polymerase.

Abstract: The present invention relates to inhibitors of HIF-1 and HIF-2 and uses thereof. The present invention further relates to the inhibitors for use in treatment of diseases. An isolated polypeptide is provided, that prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and/or inhibits the activity of HIF-1 and HIF-2, wherein the polypeptide comprises the amino acid sequence C-X1-X2-X3-Z-X4 (SEQ ID NO 1) and wherein X1, X2, X3 and X4 are any amino acid and wherein Z is leucine, valine of isoleucine or a non-natural derivative or leucine, valine or isoleucine. The isolated polypeptide prevents dimerization of HIF-1? with HIF-1? and HIF-2? with HIF-1? and inhibits the activity of HIF-1 and HIF-2 by binding to HIF-1? or HIF-1? and/or HIF-2? or HIF-1?.

Abstract: The present invention provides methods for preparing complexed diaryl boronic acids from alkyl diarylborinates.

Abstract: The present invention provides methods for preparing complexed diaryl boronic acids from alkyl diarylborinates.

Abstract: The present invention provides methods for preparing complexed diaryl boronic acids from alkyl diarylborinates.