Abstract: A vertically-oriented silicon nanowire-array based bioelectronic sensor platform is provided which includes a vertically-oriented silicon nanowire-array bioelectronic sensor including a silicon substrate doped to function as an electrically active p-n junction diode with a p-doped base and an n+-doped emitter and having a vertically-oriented silicon nanowire-array at the n+-doped emitter, a conductive contact positioned at the silicon substrate and in electrical connection with the vertically-oriented silicon nanowire-array, a dielectric stack overlaying the conductive contact, and a back contact associated with a back surface of the silicon substrate.

Abstract: A composition comprising, for example, chemically modified RNA (cmRNA) encoding CST6 or a polypeptide with at least 80% amino acid sequence identity thereto, and methods of making and using the cmRNA, are provided.

Abstract: A Descemet Membrane Endothelial Keratoplasty (DMEK) holder for placement within a vial for supporting a corneal tissue inserter is provided. The DMEK holder includes a top and an opposite bottom, at least one support member extending between the top and the bottom, with a bottom portion of the at least one support member sized and shaped to fit against a bottom inner surface of the vial to thereby support the corneal tissue inserter within the vial, and a first annular member having an opening sized and shaped such that a bottom end of the corneal tissue inserter is insertable through the opening and the first annular member separates the corneal tissue inserter from an inner surface of the vial and positions the corneal tissue inserter within the vial away from inner surfaces of the vial to thereby improve retrieval of the corneal tissue inserter by a surgeon.

Abstract: A composition comprising microparticles or liposomes comprising one or more MEK1/2 inhibitors, and methods of using the composition, are provided.

Abstract: A sustained release composition comprising one or more particles comprising a polymer and an amount of a select androgen receptor modulator (SARM), and methods of making and using the composition, are provided.

Abstract: A composition comprising nanoparticles having a molecule that is a cell targeting or cell penetrating molecule and an anti-oxidant, and methods of making and using the composition, are provided.

Abstract: Composition and methods to prevent, inhibit or treat one or more symptoms of cystic fibrosis are provided.

Abstract: The invention provides methods, compositions, and kits that are useful for treating cancer (e.g., endometrial cancer).

Abstract: A composition comprising particles formed of poly(diaminosulfide) and one or more leptospiral antigens, and methods of making and using the composition, are provided.

Abstract: A molecule comprising a G-protein coupled estrogen receptor (GPER) ligand coupled to a linker coupled to an E3 ubiquitin ligase ligand and methods of using the molecule are provided. In one embodiment, the GPER ligand is estradiol and the E3 ubiquitin ligase ligand is (S,R,S)- AHPC.

Abstract: A cationic nanoparticle formed of a biodegradable or biocompatible synthetic polymer and a dendrimer having a diameter of about 125 nm to 1000 nm, and methods of using the nanoparticle, e.g., for delivery of an immunogen, are provided.

Abstract: Compositions comprising nanoparticles, nanoplexes or virus comprising isolated nucleic acid comprising nucleic acid encoding a mammalian, and methods of using the compositions, are provided.

Abstract: Compounds that inhibit JNK, e.g., JNK2 and/or JNK3, such as fused thiophenes, and methods of making and using the compounds are provided.

Abstract: A method to prevent, inhibit or treat intervertebral disc disease in a mammal and compositions useful in that regard are provided.

Abstract: A composition comprising an amount of an anti-oxidant comprising one or more of ubiquinol, MitoQ, vitamin E, vitamin C, ascorbate-2-phosphate, idebenone, pyrroloquinoline quinone (PQQ), N-acetyl-L-cysteine (NAC), palmitate, reduced glutathione, or a C14-C18 saturated fatty acid effective to preserve, e.g., corneal tissue, and methods of using the composition, are provided.

Abstract: A nanoparticle comprising one or more quinonemethide triterpenoids or one or more inhibitors of metadherin, and methods of using the nanoparticles, are provided.

Abstract: Disclosed are nanoparticle compositions and methods for treating cancer in a subject in need thereof. The nanoparticle compositions and methods may be utilized to treat cancers in a subject that are characterized by susceptibility to synthetic lethality via administering a combination of agents that induce synthetic lethality.

Abstract: A Descemet Membrane Endothelial Keratoplasty (DMEK) holder for placement within a vial for supporting a corneal tissue inserter is provided. The DMEK holder includes a top and an opposite bottom, at least one support member extending between the top and the bottom, with a bottom portion of the at least one support member sized and shaped to fit against a bottom inner surface of the vial to thereby support the corneal tissue inserter within the vial, and a first annular member having an opening sized and shaped such that a bottom end of the corneal tissue inserter is insertable through the opening and the first annular member separates the corneal tissue inserter from an inner surface of the vial and positions the corneal tissue inserter within the vial away from inner surfaces of the vial to thereby improve retrieval of the corneal tissue inserter by a surgeon.

Abstract: A composition comprising particles formed of poly(diamidosulfide) and one or more leptospiral antigens, and methods of making and using the composition, are provided.

Abstract: A composition comprising microparticles or liposomes comprising one or more MEK1/2 inhibitors, and methods of using the composition, are provided.