Abstract: Provided is a method of using a nanowire diode with an array of more than 100 nanowires functionalized with binding agents that bind to one or more specific biomarkers, the nanowires being non-horizontally aligned on a substrate, and the nanowires being electrically connected to each other, to measure the presence or absence of the one or more specific biomarkers. The method comprises exposing the nanowires to a solution of interest, shining light with a wavelength between 350 nm and 700 nm on the nanowire diode, measuring electrical current that is optically induced in the nanowire diode by the light, and comparing the optically induced electrical current with and without the solution of interest present to deduce a concentration of the one or more specific biomarkers in the solution of interest.

Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a to inhibit ossification and bone formation.

Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a to inhibit ossification and bone formation.

Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention provides the use of miR-200a inhibitor to stimulate bone regeneration.

Abstract: Provided is a biosensor including a nanowire array. According to an example, the nanowire may include at least 1000 nanowires per cm2, the at least 1000 nanowires per cm2 including individual nanowires each defined by a longitudinal surface and a vertical surface, the longitudinal surface being at least two times longer than the vertical surface, where the vertical surfaces of each of the individual nanowires is configured to couple to a substrate.

Abstract: In certain embodiments, the present invention provides the use of microRNA (miR)-200a and/or miR-200c to inhibit ossification and bone formation. In certain embodiments, the present invention provides the use of miR-200a inhibitor to stimulate bone regeneration.

Abstract: Provided is a biosensor including a nanowire array. According to an example, the nanowire may include at least 1000 nanowires per cm2, the at least 1000 nanowires per cm2 including individual nanowires each defined by a longitudinal surface and a vertical surface, the longitudinal surface being at least two times longer than the vertical surface, where the vertical surfaces of each of the individual nanowires is configured to couple to a substrate.

Abstract: The present invention provides methods and compositions for cell-based arrays. A biotin-avidin system for the attachment of cells onto a surface also employs biodegradable polymers onto which avidin is disposed in a predetermined pattern.

Abstract: The present invention relates to the treatment of cancer using a polymer-based delivery system to provide a plurality of tumor cell antigens to a immunocompetent subject in conjunction with an immunodulatory substance.

Abstract: This invention is predicated on the present applicants' discovery that nanostructures comprising discrete regions of different composition can be used to deliver to a biological cell a desired combination of molecules in close proximity. Different molecules can be selectively bonded to discrete regions of different composition in sufficiently close physical relationship to enhance delivery or effectiveness within the cell. The preferred nanostructures are multicomponent nanorods. Important applications include delivery of missing DNA sequences for gene therapy and delivery of antigens or DNA encoding antigens for vaccination.