Patents by Inventor Alice A. Chen

Alice A. Chen has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Abnormal syngamy phenotypes observed with time lapse imaging for early identification of embryos with lower development potential
    Patent number: 10241108
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans.
    Type: Grant
    Filed: February 3, 2014
    Date of Patent: March 26, 2019
    Assignee: ARES TRADING S.A.
    Inventors: Shehua Shen, Alice A. Chen Kim, Kelly Athayde Wirka, Vaishali Suraj, Lei Tan
  • Implantable human liver tissue constructs and uses thereof
    Patent number: 10004826
    Abstract: Engineered human tissue constructs are provided that are suitable for use in making humanized animals for use in pharmaceutical development. Humanized animals having the constructs implanted in vivo are provided. Methods of making and using the tissue-engineered constructs and humanized animals are also provided.
    Type: Grant
    Filed: October 6, 2011
    Date of Patent: June 26, 2018
    Assignee: Massachusetts Institute of Technology
    Inventors: Sangeeta N. Bhatia, Alice A. Chen, Shengyong Ng
  • Measuring Embryo Development and Implantation Potential With Timing and First Cytokinesis Phenotype Parameters
    Publication number: 20160305935
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: November 19, 2015
    Publication date: October 20, 2016
    Inventors: Kelly Athayde Wirka, Shehua Shen, Alice A. Chen Kim, Vaishali Suraj, Lei Tan
  • In Vitro Embryo Blastocyst Prediction Methods
    Publication number: 20150346187
    Abstract: Methods, compositions and kits for determining the likelihood of reaching the blastocyst stage for one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: June 3, 2015
    Publication date: December 3, 2015
    Inventors: Kevin E. Loewke, Vaishali Suraj, Alice A. Chen Kim
  • MEASURING EMBRYO DEVELOPMENT AND IMPLANTATION POTENTIAL WITH TIMING AND FIRST CYTOKINESIS PHENOTYPE PARAMETERS
    Publication number: 20140220618
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: February 3, 2014
    Publication date: August 7, 2014
    Applicant: Auxogyn, Inc.
    Inventors: Kelly Athayde WIRKA, Shehua SHEN, Alice A. CHEN KIM, Vaishali SURAJ, Lei TAN
  • ABNORMAL SYNGAMY PHENOTYPES OBSERVED WITH TIME LAPSE IMAGING FOR EARLY IDENTIFICATION OF EMBRYOS WITH LOWER DEVELOPMENT POTENTIAL
    Publication number: 20140220619
    Abstract: Methods, compositions and kits for determining the developmental potential of one or more embryos are provided. These methods, compositions and kits find use in identifying embryos in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: February 3, 2014
    Publication date: August 7, 2014
    Applicant: Auxogyn, Inc.
    Inventors: Shehua SHEN, Alice A. Chen Kim, Kelly Athayde Wirka, Vaishali Suraj, Lei Tan
  • IN VITRO EMBRYO BLASTOCYST PREDICTION METHODS
    Publication number: 20130337487
    Abstract: Methods, compositions and kits for determining the likelihood of reaching the blastocyst stage for one or more embryos or pluripotent cells are provided. These methods, compositions and kits find use in identifying embryos and oocytes in vitro that are most useful in treating infertility in humans.
    Type: Application
    Filed: May 31, 2013
    Publication date: December 19, 2013
    Inventors: Kevin E. LOEWKE, Vaishali Suraj, Alice A Chen Kim
  • HUMANIZED ANIMALS VIA TISSUE ENGINEERING AND USES THEREOF
    Publication number: 20120216304
    Abstract: Engineered human tissue constructs are provided that are suitable for use in making humanized animals for use in pharmaceutical development. Humanized animals having the constructs implanted in vivo are provided. Methods of making and using the tissue-engineered constructs and humanized animals are also provided.
    Type: Application
    Filed: October 6, 2011
    Publication date: August 23, 2012
    Inventors: Sangeeta N. BHATIA, Alice A. CHEN, Shengyong Ng
  • Compositions and Methods to Monitor RNA Delivery to Cells
    Publication number: 20090317802
    Abstract: Methods and compositions for tracking or monitoring uptake of siRNA by mammalian cells are provided. The methods and compositions may be used to monitoring the silencing activity of the internalized siRNA. The compositions contain an siRNA, an optically or magnetically detectable nanoparticle such as a quantum dot and, optionally, a transfection reagent. Cells are contacted with an siRNA and an optically or magnetically detectable nanoparticle, optionally in the presence of a transfection reagent. Detection of internalized nanoparticles is indicative of siRNA uptake. The invention allows analysis, identification, processing, etc., of cells that have efficiently taken up siRNA. In one embodiment, cells are sorted into at least two populations based on the amount of siRNA taken up.
    Type: Application
    Filed: December 8, 2006
    Publication date: December 24, 2009
    Inventors: Sangeeta N. Bhatia, Austin M. Derfus, Alice A. Chen