Patents by Inventor Alice A. McDonald

Alice A. McDonald has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IRAK4 DEGRADERS AND USES THEREOF
    Publication number: 20230277519
    Abstract: The present invention relates to IRAKIMiD degraders, their liquid formulations, and methods of use thereof for treating cancer.
    Type: Application
    Filed: January 13, 2023
    Publication date: September 7, 2023
    Inventors: Jared Gollob, Jeffrey Davis, Ashwin Gollerkeri, Reginald EWESUEDO, Alice McDonald, Vashali Dixit, Shu-Pei Wu, Michele Mayo, Haojing Rong, Sagar Agarwal, Bradley Enerson, Patrick Henrick, Rachelle Perea, Christopher Ho, William Leong, Duncan Walker
  • IRAK DEGRADERS AND USES THEREOF
    Publication number: 20230241075
    Abstract: The present invention provides methods for identifying or selecting a patient having an elevated level of an inflammatory biomarker, and methods for treating a disease or disorder in a patient comprising selecting a patient having an elevated level of an inflammatory biomarker, and administering to the patient an IRAK degrader.
    Type: Application
    Filed: June 17, 2021
    Publication date: August 3, 2023
    Inventors: Veronica CAMPBELL, Alice MCDONALD, Jared GOLLOB, Anthony SLAVIN
  • USE OF EZH2 INHIBITORS FOR TREATING CANCER
    Publication number: 20230201213
    Abstract: The present disclosure provides methods for the treatment of a cancer characterized by at least one tumor comprising intratumoral B cells and/or stromal B cells, in a subject, comprising administering to the subject an EZH2 inhibitor. The present disclosure also provides methods of identifying a subject having cancer for treatment with an EZH2 inhibitor of determining the response of a subject to an EZH2-inhibitor therapy, the methods comprising determining the level of intratumoral B cells and/or stromal B cells. The present disclosure also provides a method of decreasing the number and/or density of intratumoral B cells and/or stromal B cells in a tumor in a subject, comprising administering to the subject an EZH2 inhibitor.
    Type: Application
    Filed: May 27, 2021
    Publication date: June 29, 2023
    Inventors: Carly CAMPBELL, Kat COSMOPOULOS, Alice MCDONALD, Melinda MERCHANT, Neil MICHAUD, Attila SZANTO
  • IRAK4 DEGRADERS AND USES THEREOF
    Publication number: 20220273668
    Abstract: The present invention provides IRAK4 degraders, formulations and unit dosage forms thereof, and methods of use thereof.
    Type: Application
    Filed: February 15, 2022
    Publication date: September 1, 2022
    Inventors: Jared GOLLOB, Jeffrey DAVIS, Alice MCDONALD, Haojing RONG
  • ANTI-GCC ANTIBODY MOLECULES AND METHODS FOR USE OF SAME
    Publication number: 20160130344
    Abstract: Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
    Type: Application
    Filed: January 19, 2016
    Publication date: May 12, 2016
    Inventors: Helen A. Frank, Alice McDonald, Theresa L. O'Keefe
  • Anti-GCC antibody molecules and methods for use of same
    Patent number: 9273146
    Abstract: Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
    Type: Grant
    Filed: February 27, 2015
    Date of Patent: March 1, 2016
    Assignee: MILLENNIUM PHARMACEUTICALS, INC.
    Inventors: Helen A. Frank, Alice Mcdonald, Theresa L. O'Keefe
  • Anti-GCC antibody molecules and methods for use of same
    Patent number: 9000129
    Abstract: Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
    Type: Grant
    Filed: April 27, 2013
    Date of Patent: April 7, 2015
    Assignee: Millennium Pharmaceuticals, Inc.
    Inventors: Helen Alison Frank, Alice A. McDonald, Theresa L. O'Keefe
  • ANTI-GCC ANTIBODY MOLECULES AND METHODS FOR USE OF SAME
    Publication number: 20130287783
    Abstract: Antibodies and antigen-binding fragments of antibodies that bind GCC are disclosed. The invention also provides therapeutic and diagnostic methods utilizing the antibodies and antigen-binding fragments provided herein.
    Type: Application
    Filed: April 27, 2013
    Publication date: October 31, 2013
    Applicant: MILLENNIUM PHARMACEUTICALS, INC.
    Inventors: Helen Alison Frank, Alice A. McDonald, Theresa L. O'Keefe