Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Abstract: The present invention comprises an athletic undergarment having trunk and leg portions woven from a sheer, resiliently elastic material and foot portions knit from heavy compressible yarn. The leg portions are permanently secured to the interior of the foot portions by stitching in a manner which maximizes the area of contact between the yarn and the wearer's feet. The resilient elasticity of the sheer trunk and leg portions furnish muscle support and circulatory stimulation for the wearer's legs, while the knit foot portions prevent relative slippage and excessive perspiration build-up between the foot portions and the wearer's shoes.

Abstract: The present invention comprises an athletic undergarment having trunk and leg portions woven from a sheer, resiliently elastic material and foot portions knit from heavy compressible yarn. The leg portions are permanently secured to the interior of the foot portions in a manner which both maximizes the area of contact between the yarn and the wearer's feet and reduces the tendency of the foot portions to unravel following periods of prolonged usage. The resilient elasticity of the sheer trunk and leg portions furnish muscle support and circulatory stimulation for the wearer's legs, while the knit foot portions prevent relative slippage and excessive perspiration build-up between the foot portions, leg portions and the wearer's shoes.