Abstract: Technologies are described herein for improvements in the security of verifiable credentials. A method can include requesting, by a first decentralized identifier (DID) associated with a decentralized web node (DWN), a verifiable credential from a second DID, wherein the second DID is included in a pool of DIDs. The method also includes receiving, from the pool of DIDs and by the first DID, the verifiable credential. The method also includes receiving, from a third DID and at the first DID, a request to verify information associated with the first DID. The method also includes determining, at the DWN, that the verifiable credential includes the information requested by the third DID. The method also includes presenting, by the DWN, at least a portion of the verifiable credential to the third DID in response to determining that the verifiable credential includes the information.

Abstract: This disclosure provides compositions comprising engineered ureteric bud kidney tissues and methods of making lumenized ureteric bud kidney tissues. Also provided herein are in vitro kidneys comprising nephron progenitor cells and ureteric bud cells. Methods of making the compositions and in vitro kidneys and uses thereof are disclosed herein. In some aspects, provided herein are methods for generating a lumenized kidney tissue having a spatially-controlled 3-dimensional (3D) tubular architecture in vitro.

Abstract: The present disclosure provides methods and systems for managing digital looks. The method may comprise providing access to a digital look. The digital look may comprise a virtual arrangement of one or more fashion articles selected by an algorithm or an individual who is not a consumer. The method may further comprise providing a user interface for a consumer to (i) view and modify the one or more fashion articles in the digital look and (ii) select at least one or more fashion articles to purchase. The user interface may comprise a purchase list corresponding to the one or more fashion articles in the digital look. Modifying the one or more fashion articles in the digital look may comprise rearranging, add, removing, or customizing one or more fashion articles.

Abstract: A method for administering object-based multi-level security in a service oriented architecture includes: (a) defining a plurality of multi-level security attributes for each of selected respective life-cycle states of a plurality of life-cycle states of a service object; (b) receiving a request from a requestor for the service object; (c) determining permitted actions for the service object based upon at least one selected multi-level security attribute of the plurality of multi-level security attributes, and based upon at least one life-cycle state of the plurality of life-cycle states of the service object; and (d) generating a quality of service security contract based upon the determination of permitted actions.

Abstract: A method of managing information system resources to provide a message flow having a consistent level of quality of service (QoS) within and across a plurality of interconnected middleware domains is described. The method includes receiving a QoS message from a first QoS manager expressing at least one QoS requirement, translating the at least one QoS requirement to at least one parameter specific to a messaging service that communicatively couples multiple middleware domains, creating a client connection between a first middleware domain and the messaging service for receiving the message flow, transmitting the QoS message to a second middleware domain, and creating a client connection between the messaging service and the second middleware domain for transmitting the message flow.

Abstract: A method of managing resources of an information system relative to clients of the system. A quality of service (QoS) message is received from a client expressing QoS requirements as parameter values. A contract is established with the client for quality of service based on the one or more parameter values. One or more resources of the system are allocated to the client based on the contract. This method enables uniform resource management and polymorphic resource allocation across multiple middleware platforms.

Abstract: A method of managing information system resources to provide a message flow having a consistent level of quality of service (QoS) within and across a plurality of interconnected middleware domains is described. The method includes receiving a QoS message from a first QoS manager expressing at least one QoS requirement, translating the at least one QoS requirement to at least one parameter specific to a messaging service that communicatively couples multiple middleware domains, creating a client connection between a first middleware domain and the messaging service for receiving the message flow, transmitting the QoS message to a second middleware domain, and creating a client connection between the messaging service and the second middleware domain for transmitting the message flow.

Abstract: A method of managing information system resources to provide a message flow having a consistent level of quality of service (QoS) within and across a plurality of interconnected middleware domains is described. The method includes receiving a QoS message from a first QoS manager expressing at least one QoS requirement, translating the at least one QoS requirement to at least one parameter specific to a messaging service that communicatively couples multiple middleware domains, creating a client connection between a first middleware domain and the messaging service for receiving the message flow, transmitting the QoS message to a second middleware domain, and creating a client connection between the messaging service and the second middleware domain for transmitting the message flow.

Abstract: An interactive, handheld apparatus is provided. The apparatus includes a housing, a display screen on the housing, an electronic position location system, a stylus for selecting images on the display screen, a directional control pad on the housing and a memory device. The electronic position location system includes a processor that is capable of determining a location of a selected region of the display screen. The memory device includes computer code for an educational game and is operatively coupled to the processor.

Abstract: A method of managing information system resources to provide a message flow having a consistent level of quality of service (QoS) within and across a plurality of interconnected middleware domains is described. The method includes receiving a QoS message from a first QoS manager expressing at least one QoS requirement, translating the at least one QoS requirement to at least one parameter specific to a messaging service that communicatively couples multiple middleware domains, creating a client connection between a first middleware domain and the messaging service for receiving the message flow, transmitting the QoS message to a second middleware domain, and creating a client connection between the messaging service and the second middleware domain for transmitting the message flow.

Abstract: A method for administering object-based multi-level security in a service oriented architecture includes: (a) defining a plurality of multi-level security attributes for each of selected respective life-cycle states of a plurality of life-cycle states of a service object; (b) receiving a request from a requestor for the service object; (c) determining permitted actions for the service object based upon at least one selected multi-level security attribute of the plurality of multi-level security attributes, and based upon at least one life-cycle state of the plurality of life-cycle states of the service object; and (d) generating a quality of service security contract based upon the determination of permitted actions.

Abstract: Method and system of building a reasoning model using relational databases is provided. The method includes identifying data objects in relational databases; determining dependency relationships between the data objects; translating the data objects into nodes of a Bayesian network; and automatically translating the dependency relationships into a graphical structure of a Bayesian network. The system includes at least one server for storing data of a system having numerous interconnected parts; monitoring agents for monitoring the data of the numerous interconnected parts stored in the system; an events log for storing any event observed by the monitoring agents; and relational databases for storing data objects, the data objects correspond to the data of the numerous interconnected parts.

Abstract: An interactive, handheld apparatus is provided. The apparatus includes a housing, a display screen on the housing, an electronic position location system, a stylus for selecting images on the display screen, a directional control pad on the housing and a memory device. The electronic position location system includes a processor that is capable of determining a location of a selected region of the display screen. The memory device includes computer code for an educational game and is operatively coupled to the processor.

Abstract: A method of managing resources of an information system relative to clients of the system. A quality of service (QoS) message is received from a client expressing QoS requirements as parameter values. A contract is established with the client for quality of service based on the one or more parameter values. One or more resources of the system are allocated to the client based on the contract. This method enables uniform resource management and polymorphic resource allocation across multiple middleware platforms.

Abstract: The present invention provides purified disease detection and treatment molecule polynucleotides (mddt). Also encompassed are the polypeptides (MDDT) encoded by mddt. The invention also provides for the use of mddt, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing mddt for the expression of MDDT. The invention additionally provides for the use of isolated and purified MDDT to induce anitbodies and to screen libraries of compounds and the use of anti-MDDT antibodies in diagnostic assays. Also provided are microarrays containing mddt and methods of use.

Abstract: The present invention provides novel JNK activating phosphatase polypeptides and nucleic acid molecules encoding the same. The invention also provides vectors, host cells, antibodies and methods for producing JNK activating phosphatase polypeptides. Also provided for are methods for the diagnosis and treatment of diseases associated with JNK activating phosphatase polypeptides.

Abstract: An interactive, handheld apparatus is provided. The apparatus includes a housing, a display screen on the housing, an electronic position location system, a stylus for selecting images on the display screen, a directional control pad on the housing and a memory device. The electronic position location system includes a processor that is capable of determining a location of a selected region of the display screen. The memory device includes computer code for an educational game and is operatively coupled to the processor.

Abstract: The present invention provides purified secretory polynucleotides (sptm). Also encompassed are the polypeptides (SPTM) encoded by sptm. The invention also provides for the use of sptm, or complements, oligonucleotides, or fragments thereof in diagnostic assays. The invention further provides for vectors and host cells containing sptm for the expression of SPTM. The invention additionally provides for the use of isolated and purified SPTM to induce antibodies and to screen libraries of compounds and the use of anti-SPTM antibodies in diagnostic assays. Also provided are microarrays containing sptm and methods of use.