Patents by Inventor Alice L. Wang

Alice L. Wang has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240325495
    Abstract: Disclosed herein are methods of treating a disease or disorder in a subject in need thereof, comprising administering to the subject one or more doses of an Interleukin-2 (IL2) fusion protein, wherein the dose is from about 0.1 mg to about 9 mg. Also disclosed herein are methods of treating a disease or disorder in a subject in need thereof, comprising administering to the subject an dose of an IL2 fusion protein, wherein the dose is greater than about 9 mg. The IL2 fusion proteins used in the methods disclosed herein comprise: (a) a first polypeptide comprising an IL2 polypeptide; and (b) a second polypeptide comprising an extracellular domain of an IL2 Receptor alpha (IL2R) polypeptide. In some aspects, the disease or disorder is an immune-mediated disease, such as systemic lupus erythematosus. In some aspects, the methods further administering a corticosteroid to the subject.
    Type: Application
    Filed: October 29, 2021
    Publication date: October 3, 2024
    Applicant: Bristol-Myers Squibb Company
    Inventors: Alice L. WANG, Mary STRUTHERS, Kimberly MCGORMAN, Neelanjana RAY, Karen D. PRICE, Nidhi SHARDA, Eun Mi HUR, Priyanka Apurva MADIA
  • Patent number: 6133018
    Abstract: 2-Aminopropane is used as the amine donor in the stereoselective synthesis of a chiral amine from a ketone with a transaminase. In a typical embodiment, (S)-1-methoxy-2-aminopropane is prepared by bringing methoxyacetone into contact with a transaminase in the presence of 2-aminopropane as an amine donor until a substantial amount of methoxyacetone is converted to (S)-1-methoxy-2-aminopropane and 2-aminopropane is converted to acetone. In a second embodiment, L-alanine is prepared by bringing pyruvic acid into contact with a transaminase in the presence of 2-aminopropane as an amine donor.
    Type: Grant
    Filed: March 10, 1999
    Date of Patent: October 17, 2000
    Assignee: Celgro
    Inventors: Wei Wu, Mohit B. Bhatia, Craig M. Lewis, Wei Lang, Alice L. Wang, George W. Matcham