Abstract: Systems, methods, devices, and compounds for facilitating a capsule are provided. The capsule includes a first hollow body and a second hollow body configured to couple together, which collectively form an interior volume of the capsule. The capsule includes a divider that includes a base and a sidewall protruding from a first circumferential edge portion of the base. The sidewall includes an inner surface, an outer surface, and a second circumferential edge portion. The second circumferential edge portion is configured to continuously engage a unique circumferential surface of the capsule, which secures the divider within the interior volume of the capsule and forms at least two unique interior volumes based on a position of the t divider and the unique circumferential surface of the capsule. The capsule includes a plurality of pharmaceutical compositions, each of which occupies a unique interior volume in the at least two unique interior volumes.

Abstract: Systems and methods for implementing one or more compiled workflows at a biological foundry are provided. A representation of an uncompiled workflow to produce engineering targets is obtained. The representation is translated into a first corresponding instance of a compiled workflow. If the translation satisfaction of various threshold translation criteria is determined, and the first corresponding instance of the compiled workflow is executed to complete a first portion of manufacture of the engineering targets. If the executing satisfaction of various threshold execution criteria is determined, the representation is translated into a second corresponding instance of the compiled workflow different from the first corresponding instance. If this translation satisfaction of the various threshold translation criteria is determined, the second corresponding instance of the compiled workflow is executed to complete a second portion of the manufacture of the engineering targets.

Abstract: A docking device for receiving a portable device. The docking device includes a base including a substantially planar upper surface for supporting a portable device. The docking device includes an array of a plurality of engagement members. Each engagement member in the plurality of engagement members includes a fixed body protruding upwardly from the substantially planar upper surface of the base. Each engagement member includes a spring including a fixed end portion and a free end portion for engagement with the portable device. The fixed end portion interfaces with the fixed body. The free end portion protrudes from the fixed end portion obliquely towards the substantially planar upper surface of the base. The free end being movable along a deformable gap between a first surface of the fixed body and a second surface of the spring.

Abstract: A rigid cartridge for housing and removably coupling with a soft body bioreactor is provided. The rigid cartridge includes rigid walls defining a rigid housing. The rigid walls expose a fixed interior configured to house the soft body. An interior surface of a first rigid wall includes a first mating mechanism to engage a second mating mechanism of the soft body to removably coupled with the rigid cartridge and accommodate the soft body in the fixed interior of the rigid cartridge. A rigid wall includes a planar upper surface including an aperture. Each aperture is encompassed by an annular hood protruding upwardly from the substantially planar upper surface and integrally formed with the at least one rigid wall. The aperture is configured to receive and fixed engage a corresponding connector. Each connector includes a rigid coupling mechanism that provides communication with a corresponding plurality of ports of the soft body.

Abstract: A rigid cartridge for housing and removably coupling with a soft body bioreactor is provided. The rigid cartridge includes rigid walls defining a rigid housing. The rigid walls expose a fixed interior configured to house the soft body. An interior surface of a first rigid wall includes a first mating mechanism to engage a second mating mechanism of the soft body to removably coupled with the rigid cartridge and accommodate the soft body in the fixed interior of the rigid cartridge. A rigid wall includes a planar upper surface including an aperture. Each aperture is encompassed by an annular hood protruding upwardly from the substantially planar upper surface and integrally formed with the at least one rigid wall. The aperture is configured to receive and fixed engage a corresponding connector. Each connector includes a rigid coupling mechanism that provides communication with a corresponding plurality of ports of the soft body.

Abstract: An automated batch filling apparatus comprising a first base comprising a first plurality of metering holes, a trough slidably disposed on an upper surface of the first base, one or more guides configured to constrain a motion of the trough, a gate disposed on a bottom surface of the first base, wherein the gate comprises a second plurality of metering holes, a second base disposed below the gate, wherein the second base comprise a third plurality of metering hole, and one or more vibration devices, wherein the one or more vibration devices are configured to agitate the filling apparatus.

Abstract: A method of making a capsule comprising a plurality of compartments, the method comprising: initiating extrusion of a filament solution through a filament extruder; laying the filament solution to form a base of the capsule; forming a first compartment in the plurality of compartments, wherein the forming creates a first barrier wall having a first predetermined release time; forming a second compartment in the plurality of compartments, wherein the forming creates a second barrier wall having a second predetermined release time; filling the first compartment with a first material; filling the second compartment with a second material; and sealing the plurality of compartments thereby forming the capsule with a first sealed compartment and a second sealed compartment.

Abstract: An automated batch filling apparatus comprising a first base comprising a first plurality of metering holes, a trough slidably disposed on an upper surface of the first base, one or more guides configured to constrain a motion of the trough, a gate disposed on a bottom surface of the first base, wherein the gate comprises a second plurality of metering holes, a second base disposed below the gate, wherein the second base comprise a third plurality of metering hole, and one or more vibration devices, wherein the one or more vibration devices are configured to agitate the filling apparatus.

Abstract: A dispensing system includes a filament extruder that lays filament solutions. The filament extruder comprises multiple extruder sets. Each extruder set includes a first and a second extruder. Each of the first and the second extruder includes an extruder portion, a hot end portion, and a shroud. The extruder portion includes a first and a second insert that combine to form a channel and a needle tube that receives the filament solution from the channel and lays the filament solution on the target surface.

Abstract: A method of making a capsule comprising a plurality of compartments, the method comprising: initiating extrusion of a filament solution through a filament extruder; laying the filament solution to form a base of the capsule; forming a first compartment in the plurality of compartments, wherein the forming creates a first barrier wall having a first predetermined release time; forming a second compartment in the plurality of compartments, wherein the forming creates a second barrier wall having a second predetermined release time; filling the first compartment with a first material; filling the second compartment with a second material; and sealing the plurality of compartments thereby forming the capsule with a first sealed compartment and a second sealed compartment.

Abstract: A dispensing system comprises a main base with a hopper insertion hole. An upper base, fixed above the main base by spacers, comprises a stirrer insertion hole. A lower base, below the main base, has a hopper insertion hole with an aperture larger than a diameter of a hopper, and is coupled to the main base by a guide. A rotatable hopper, disposed in the insertion hole of the main base, comprises a bottom surface with metering holes. A stirrer, inside the hopper and fixed to the upper base, feeds material into the metering holes. A gate, on a bottom surface of the lower base, comprises a bottom surface with a dispensing hole. The gate diameter is greater than the hopper. A gate spring, between the bottom of the main base and an upper surface of the lower base, is mounted parallel to a sliding motion of the lower base. A vibration device agitates the assembly on the main base.