Abstract: Disclosed herein are methods of treating a disease or disorder in a subject in need thereof, comprising administering to the subject one or more doses of an Interleukin-2 (IL2) fusion protein, wherein the dose is from about 0.1 mg to about 9 mg. Also disclosed herein are methods of treating a disease or disorder in a subject in need thereof, comprising administering to the subject an dose of an IL2 fusion protein, wherein the dose is greater than about 9 mg. The IL2 fusion proteins used in the methods disclosed herein comprise: (a) a first polypeptide comprising an IL2 polypeptide; and (b) a second polypeptide comprising an extracellular domain of an IL2 Receptor alpha (IL2R) polypeptide. In some aspects, the disease or disorder is an immune-mediated disease, such as systemic lupus erythematosus. In some aspects, the methods further administering a corticosteroid to the subject.

Abstract: The disclosed embodiments provide an apparatus and methods for assisting individuals in controlling respiratory rates. For example, a respiratory regulation apparatus is provided in the form of a plush animal toy that operates components to simulate the breathing rate of anxious individuals. The apparatus may include actuators that are controlled by a slotted cam that is dynamically rotated at varying speeds in a determined rotational direction. The actuators move inward and outward in relative directions to move a torso of the plush animal toy to simulate breathing. In certain aspects, actuators may expand outward while at the same time another actuator contracts inward to cause the torso to simulate realistic breathing movements. A processor controls the speed of the cam such that the simulated breathing of the animal toy apparatus can be reduced at a controlled rate to assist an individual in reducing their breathing rate to a calmer state.

Abstract: The disclosed embodiments provide an apparatus and methods for assisting individuals in controlling respiratory rates. For example, a respiratory regulation apparatus is provided in the form of a plush animal toy that operates components to simulate the breathing rate of anxious individuals. The apparatus may include actuators that are controlled by a slotted cam that is dynamically rotated at varying speeds in a determined rotational direction. The actuators move inward and outward in relative directions to move a torso of the plush animal toy to simulate breathing. In certain aspects, actuators may expand outward while at the same time another actuator contracts inward to cause the torso to simulate realistic breathing movements. A processor controls the speed of the cam such that the simulated breathing of the animal toy apparatus can be reduced at a controlled rate to assist an individual in reducing their breathing rate to a calmer state.

Abstract: The disclosed embodiments provide an apparatus and methods for assisting individuals in controlling respiratory rates. For example, a respiratory regulation apparatus is provided in the form of a plush animal toy that operates components to simulate the breathing rate of anxious individuals. The apparatus may include actuators that are controlled by a slotted cam that is dynamically rotated at varying speeds in a determined rotational direction. The actuators move inward and outward in relative directions to move a torso of the plush animal toy to simulate breathing. In certain aspects, actuators may expand outward while at the same time another actuator contracts inward to cause the torso to simulate realistic breathing movements. A processor controls the speed of the cam such that the simulated breathing of the animal toy apparatus can be reduced at a controlled rate to assist an individual in reducing their breathing rate to a calmer state.