Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Abstract: Machine learning is a process that learns a model from a given dataset, where the model can then be used to make a prediction about new data. In order to reduce the costs associated with collecting and labeling real world datasets for use in training the model, computer processes can synthetically generate datasets which simulate real world data. The present disclosure improves the effectiveness of such synthetic datasets for training machine learning models used in real world applications, in particular by generating a synthetic dataset that is specifically targeted to a specified downstream task (e.g. a particular computer vision task, a particular natural language processing task, etc.).

Abstract: The present disclosure provides compounds of Formula I, useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 (“TREM2”). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula I.

Abstract: A haptic actuator may include a base, a field member coupled to the base and that may include spaced apart permanent magnets. The haptic actuator may also include a coil having a loop shape defining a slotted opening therein, and a spring member suspending the coil so that the field member is within the slotted opening and permitting relative movement of the field member and the coil.

Abstract: A double helix actuator is disclosed that includes a double helix coil wound around a movable proof mass that is enclosed within a magnetic structure. The double helix coil and the magnetic structure are arranged relative to each other so that the magnetic field generated by the entirety of the double helix coil contributes to a linear force direction of the actuator. The double helix actuator produces a greater linear force density compared to traditional racetrack coil actuators, where only a portion of the coil contributes to the linear force. The double helix actuator also produces torque in addition to linear force which allows the double helix to provide unique haptic sensations in a variety of applications.

Abstract: A double helix actuator is disclosed that includes a double helix coil wound around a movable proof mass that is enclosed within a magnetic structure. The double helix coil and the magnetic structure are arranged relative to each other so that the magnetic field generated by the entirety of the double helix coil contributes to a linear force direction of the actuator. The double helix actuator produces a greater linear force density compared to traditional racetrack coil actuators, where only a portion of the coil contributes to the linear force. The double helix actuator also produces torque in addition to linear force which allows the double helix to provide unique haptic sensations in a variety of applications.

Abstract: A haptic actuator may include a base, a field member coupled to the base and that may include spaced apart permanent magnets. The haptic actuator may also include a coil having a loop shape defining a slotted opening therein, and a spring member suspending the coil so that the field member is within the slotted opening and permitting relative movement of the field member and the coil.

Abstract: Disclosed are embodiments of magnetic virtual springs for haptic systems. In an embodiment, a haptic system comprises: a magnetic housing having a surface with a surface profile; a mechanical spring system disposed in the housing, the mechanical spring system including one or more mechanical springs; a mass disposed within the housing and mechanically coupled to the mechanical spring system, the mass including or coupled to a magnet, the surface profile causing a magnetic force component to be generated in at least one direction that varies with the magnet position, the magnetic force component combining with a mechanical force component provided by the mechanical springs.

Abstract: Disclosed are embodiments of magnetic virtual springs for haptic systems. In an embodiment, a haptic system comprises: a magnetic housing having a surface with a surface profile; a mechanical spring system disposed in the housing, the mechanical spring system including one or more mechanical springs; a mass disposed within the housing and mechanically coupled to the mechanical spring system, the mass including or coupled to a magnet, the surface profile causing a magnetic force component to be generated in at least one direction that varies with the magnet position, the magnetic force component combining with a mechanical force component provided by the mechanical springs.

Abstract: A double helix actuator is disclosed that includes a double helix coil wound around a movable proof mass that is enclosed within a magnetic structure. The double helix coil and the magnetic structure are arranged relative to each other so that the magnetic field generated by the entirety of the double helix coil contributes to a linear force direction of the actuator. The double helix actuator produces a greater linear force density compared to traditional racetrack coil actuators, where only a portion of the coil contributes to the linear force. The double helix actuator also produces torque in addition to linear force which allows the double helix to provide unique haptic sensations in a variety of applications.

Abstract: A capacitive force sensor is provided that includes a first support layer and a second support layer, a dielectric layer disposed between the first support layer and the second support layer, where the dielectric layer is a non-conductive elastomer that is incompressible in the a normal direction and deflects in a shear direction, a layer of parallel conductive traces disposed between and bonded to the dielectric layer and the first support layer, and a conductive layer of parallel shear channel traces having at least two distinct channels disposed between and bonded to the dielectric layer and the second support layer, where the parallel conductive traces and the parallel shear channel traces are locally parallel to each other and provide capacitive shear force measurement sensitivity while rejecting normal forces, where the normal force measurement is decoupled from the shear force measurement.

Abstract: A capacitive force sensor is provided that includes a first support layer and a second support layer, a dielectric layer disposed between the first support layer and the second support layer, where the dielectric layer is a non-conductive elastomer that is incompressible in the a normal direction and deflects in a shear direction, a layer of parallel conductive traces disposed between and bonded to the dielectric layer and the first support layer, and a conductive layer of parallel shear channel traces having at least two distinct channels disposed between and bonded to the dielectric layer and the second support layer, where the parallel conductive traces and the parallel shear channel traces are locally parallel to each other and provide capacitive shear force measurement sensitivity while rejecting normal forces, where the normal force measurement is decoupled from the shear force measurement.

Abstract: A snorkel includes a rigid main tube, a Y-branch connected to the bottom end of the main tube by a flexible tube to hold a mouthpiece, wherein the main tube has a filter at a curved top end thereof, a side chamber with a downward outlet, a check valve in the downward outlet for letting air/water out, and a baffle suspended on the inside and sloping toward the side chamber to guide a part of the user's exhaled air toward the check valve in the downward outlet of the side chamber; the Y-branch has a check valve at a bottom end thereof for letting air/water out, and a baffle suspended on the inside and spaced between the mouthpiece and the check valve of the Y-branch to guide a part of the user's exhaled air toward the check valve of the Y-branch.