Patents by Inventor Alice Yam

Alice Yam has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • IMMUNOMODULATOR ANTIBODY DRUG CONJUGATES AND USES THEREOF
    Publication number: 20240139285
    Abstract: Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases
    Type: Application
    Filed: May 30, 2023
    Publication date: May 2, 2024
    Inventors: Alice YAM, Andreas MADERNA, Cristina ABRAHAMS, Willy SOLIS, Xiaofan LI, Ryan STAFFORD, Gang YIN, Venita DE ALMEIDA, Krishna BAJJURI, Adam A. GALAN
  • ANTI-CD3 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-CD3 ANTIBODIES AND METHODS OF MAKING AND USING ANTI-CD3 ANTIBODIES
    Publication number: 20240124585
    Abstract: The present disclosure relates to antibodies that selectively bind to CD3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: September 29, 2023
    Publication date: April 18, 2024
    Inventors: Ryan STAFFORD, Junhao YANG, Alice YAM, Joni CASTRO, Gang YIN, Cuong TRAN, Xiaofan LI, Abigail YU
  • HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA-GAMMAC DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER
    Publication number: 20240101631
    Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.
    Type: Application
    Filed: October 11, 2023
    Publication date: March 28, 2024
    Applicant: Merck Sharp & Dohme LLC
    Inventors: Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
  • ANTI-ROR1 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI ROR1 ANTIBODY CONJUGATES, AND METHODS OF MAKING AND USING ANTI-ROR1 ANTIBODY CONJUGATES
    Publication number: 20240058465
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: June 30, 2023
    Publication date: February 22, 2024
    Inventors: Amandeep Gakhal, Abigail Yu, Ryan Stafford, Jeffrey Hanson, Alice Yam, Krishna Bajjuri, Andreas Maderna, Cristina Abrahams, Xiaofan Li, Gang Yin, Miao Wen, Kristin Bedard, Daniel Calarese, Helena Kiefel
  • ANTI-ROR1 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI ROR1 ANTIBODY CONJUGATES, AND METHODS OF MAKING AND USING ANTI-ROR1 ANTIBODY CONJUGATES
    Publication number: 20240058467
    Abstract: The present disclosure relates to antibodies and antibody conjugates, for instance antibody drug conjugates, with binding specificity for receptor tyrosine kinase orphan receptor 1 (ROR1) and its isoforms and homologs, and compositions comprising the antibodies or antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibodies and antibody conjugates and compositions thereof as well as methods of using the antibodies and antibody conjugates and compositions thereof, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: July 10, 2023
    Publication date: February 22, 2024
    Inventors: AMANDEEP GAKHAL, ABIGAIL YU, RYAN STAFFORD, JEFFREY HANSON, ALICE YAM, KRISHNA BAJJURI, ANDREAS MADERNA, CRISTINA ABRAHAMS, XIAOFAN LI, GANG YIN, MIAO WEN, KRISTIN BEDARD, DANIEL CALARESE, HELENA KIEFEL
  • ANTI-CD74 ANTIBODY CONJUGATES, COMPOSITIONS COMPRISING ANTI CD74 ANTIBODY CONJUGATES AND METHODS OF USING ANTI-CD74 ANTIBODY CONJUGATES
    Publication number: 20240026008
    Abstract: Provided herein are antibody conjugates with binding specificity for CD74 and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.
    Type: Application
    Filed: July 24, 2023
    Publication date: January 25, 2024
    Inventors: Ryan STAFFORD, Alice YAM, Avinash GILL, Kalyani PENTA, Xiaofan LI, Aaron SATO
  • Human interleukin-2 conjugates biased for the interleukin-2 receptor beta GAMMAc dimer and conjugated to a nonpeptidic, water-soluble polymer
    Patent number: 11827684
    Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.
    Type: Grant
    Filed: April 20, 2021
    Date of Patent: November 28, 2023
    Assignee: Merck Sharp & Dohme LLC
    Inventors: Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
  • BISPECIFIC ANTIBODY-DRUG CONJUGATES TARGETING EGFR AND MUC1 AND USES THEREOF
    Publication number: 20230310629
    Abstract: Provided are immunoconjugates comprising bispecific anti-MUC 1/EGFR antibodies conjugated to hemiasterlin-based moieties via cleavable linkers, and pharmaceutical compositions thereof. Provided also are methods of treating cancer using such immunoconjugates and pharmaceutical compositions.
    Type: Application
    Filed: June 3, 2021
    Publication date: October 5, 2023
    Inventors: Christine Knuehl, Lars Toleikis, Christiane Amendt, Achim Doerner, Alice Yam, Xiaofan Li, Ryan Stafford, Robert Henningsen, Sihong Zhou
  • Immunomodulator antibody drug conjugates and uses thereof
    Patent number: 11744876
    Abstract: Provided herein are compounds, trifunctional antibody products thereof, and methods and pharmaceutical compositions for use in treatment of inflammatory and/or proliferative diseases.
    Type: Grant
    Filed: June 10, 2020
    Date of Patent: September 5, 2023
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Alice Yam, Andreas Maderna, Cristina Abrahams, Willy Solis, Xiaofan Li, Ryan Stafford, Gang Yin, Venita De Almeida, Krishna Bajjuri, Adam A. Galan
  • Anti-CD74 antibody conjugates, compositions comprising anti-CD74 antibody conjugates and methods of using anti-CD74 antibody conjugates
    Patent number: 11708413
    Abstract: Provided herein are antibody conjugates with binding specificity for CD74 and compositions comprising the antibody conjugates, including pharmaceutical compositions, methods of producing the conjugates, and methods of using the conjugates and compositions for therapy.
    Type: Grant
    Filed: January 27, 2017
    Date of Patent: July 25, 2023
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Ryan Stafford, Alice Yam, Avinash Gill, Kalyani Penta, Xiaofan Li, Aaron Sato
  • ANTI-BCMA ANTIBODY CONJUGATES
    Publication number: 20220362394
    Abstract: The present disclosure relates to antibody conjugates with binding specificity for BCMA (BCMA) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibody conjugates and compositions as well as methods of using the antibody conjugates and compositions, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: May 1, 2020
    Publication date: November 17, 2022
    Applicant: SUTRO BIOPHARMA, INC.
    Inventors: John LEE, Ryan STAFFORD, Alice YAM, Xiaofan LI, Abigail YU, Amandeep GAKHAL, Stephanie ARMSTRONG
  • ANTI-BCMA ANTIBODY CONJUGATE, COMPOSITIONS COMPRISING THE SAME, AND METHODS OF MAKING AND USING THE SAME
    Publication number: 20220323599
    Abstract: The present disclosure relates to antibody conjugates with binding specificity for BCMA (BCMA) and its isoforms and homologs, and compositions comprising the antibody conjugates, including pharmaceutical compositions. Also provided are methods of producing the antibody conjugates and compositions as well as methods of using the antibody conjugates and compositions, such as in therapeutic and diagnostic methods.
    Type: Application
    Filed: May 1, 2020
    Publication date: October 13, 2022
    Applicant: CELGENE CORPORATION
    Inventors: John LEE, Ryan STAFFORD, Alice YAM, Xiaofan LI, Abigail YU, Amandeep GAKHAL
  • ANTI-EpCAM ANTIBODIES, COMPOSITIONS COMPRISING ANTI-EpCAM ANTIBODIES AND METHODS OF MAKING AND USING ANTI-EpCAM ANTIBODIES
    Publication number: 20220106401
    Abstract: Provided herein are antibodies that selectively bind to EpCAM and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: August 5, 2021
    Publication date: April 7, 2022
    Inventors: Ryan STAFFORD, Alice YAM, John LEE, Stephanie ARMSTRONG, Aaron SATO
  • ANTI-TIM-3 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-TIM-3 ANTIBODIES AND METHODS OF MAKING AND USING ANTI-TIM-3 ANTIBODIES
    Publication number: 20210403558
    Abstract: Provided herein are antibodies that selectively bind to Tim-3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: May 6, 2021
    Publication date: December 30, 2021
    Inventors: Ryan STAFFORD, Alice YAM, John LEE, Junhao YANG, Aaron SATO
  • HUMAN INTERLEUKIN-2 CONJUGATES BIASED FOR THE INTERLEUKIN-2 RECEPTOR BETA GAMMAc DIMER AND CONJUGATED TO A NONPEPTIDIC, WATER-SOLUBLE POLYMER
    Publication number: 20210340207
    Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.
    Type: Application
    Filed: April 20, 2021
    Publication date: November 4, 2021
    Applicant: Merck Sharp & Dohme Corp.
    Inventors: Cristina Abrahams, Edward Bowman, Xiaofan Li, Songnian Lin, Willy Solis, Ryan Stafford, Aarron Willingham, Alice Yam, Junhao Yang, Gang Yin
  • ANTI-CD74 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-CD74 ANTIBODIES AND METHODS OF USING ANTI-CD74 ANTIBODIES
    Publication number: 20210284739
    Abstract: Provided herein are antibodies that selectively bind to CD74 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: March 9, 2021
    Publication date: September 16, 2021
    Inventors: Kalyani PENTA, Ryan STAFFORD, Avinash GILL, Xiaofan LI, Alice YAM, Christopher THANOS, Aaron SATO
  • Anti-EpCAM antibodies, compositions comprising anti-EpCAM antibodies and methods of making and using anti-EpCAM antibodies
    Patent number: 11098131
    Abstract: Provided herein are antibodies that selectively bind to EpCAM and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Grant
    Filed: July 28, 2016
    Date of Patent: August 24, 2021
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Ryan Stafford, Alice Yam, John Lee, Stephanie Armstrong, Aaron Sato
  • Anti-Tim-3 antibodies, compositions comprising anti-Tim-3 antibodies and methods of making and using anti-Tim-3 antibodies
    Patent number: 11014983
    Abstract: Provided herein are antibodies that selectively bind to Tim-3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Grant
    Filed: August 17, 2016
    Date of Patent: May 25, 2021
    Assignee: SUTRO BIOPHARMA, INC.
    Inventors: Ryan Stafford, Alice Yam, John Lee, Junhao Yang, Aaron Sato
  • ANTI-BCMA RECEPTOR ANTIBODIES, COMPOSITIONS COMPRISING ANTI BCMA RECEPTOR ANTIBODIES AND METHODS OF MAKING AND USING ANTI-BCMA ANTIBODIES
    Publication number: 20210130483
    Abstract: The present disclosure relates to antibodies that selectively bind to B-cell maturation antigen (BCMA) and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: March 25, 2019
    Publication date: May 6, 2021
    Inventors: Alice YAM, Ryan STAFFORD, Xiaofan LI, Junhao YANG, Stephanie ARMSTRONG, Abigail YU
  • ANTI-PD-1 ANTIBODIES, COMPOSITIONS COMPRISING ANTI-PD-1 ANTIBODIES AND METHODS OF USING ANTI-PD-1 ANTIBODIES
    Publication number: 20210107981
    Abstract: Provided herein are antibodies that selectively bind to PD-1 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.
    Type: Application
    Filed: October 12, 2020
    Publication date: April 15, 2021
    Inventors: Alice YAM, Ryan STAFFORD, Aaron SATO, John LEE, Avinash GILL, Junhao YANG, Heather STEPHENSON