Abstract: A method is provided for forming an integrated circuit (IC) chip package structure. The method includes providing a substrate for an interposer, and forming a conductive interconnect structure in and on the substrate for connecting a group of selected IC dies. The method includes forming warpage-reducing trenches in non-routing regions of the interposer, wherein the warpage-reducing trenches are sized and positioned based on a warpage characteristic to reduce the warpage of the chip package structure. The method also includes depositing a warpage-relief material in the warpage-reducing trenches according to the warpage characteristic to reduce the warpage of the chip package structure, and bonding the group of selected IC dies to the interposer to form a chip package structure.

Abstract: The present disclosure relates to antibodies that selectively bind to CD3 and its isoforms and homologs, and compositions comprising the antibodies. Also provided are methods of using the antibodies, such as therapeutic and diagnostic methods.

Abstract: Interleukin-2 (IL-2) conjugates comprising at least one or more amino acid substitutions that bias binding to the IL-2 receptor ??c dimer over binding the IL-2 receptor ???c trimer and a non-natural amino acid at or near the N-terminus conjugated to a water-soluble polymer are described. The IL-2 conjugates are useful for treatment and prevention of cell proliferation and cancer in a patient.

Abstract: Systems, devices, and methods for treating a diseased native valve in a patient, the system comprising a compressible and expandable frame structure and an anchor. The anchor comprises a wire having a free end and is configured to be fully advanced from an atrial side of a native valve in a patient into a ventricle of the heart and anchor the frame structure to the native valve when the frame structure is in the expanded configuration adjacent the native valve.

Abstract: A method for treating a diseased native valve in a patient includes 5 advancing a distal end of a delivery device to a first side of a native valve, deploying an anchor from a delivery configuration to a deployed configuration on the first side of the native valve, and rotating the distal end of the delivery device so as to simultaneously extend the anchor in the deployed configuration through the native valve from the first side to a second side of the native valve and 10 rotate the anchor in the deployed configuration around native chordae.

Abstract: A heart valve prosthesis for replacing a diseased native valve in a patient, the valve includes a compressible and expandable frame structure and an anchor connected to an outer periphery of the frame structure. The anchor comprises a free end and has a flat spiral shape. The valve may further include a valve segment mounted within the frame structure and expanded with the frame structure. The frame structure may be configured for receiving a valve segment.

Abstract: A method for treating a diseased native valve in a patient includes advancing a distal end of a delivery device that is detachable coupled to an anchor to a first side of a native valve, deploying the anchor from a delivery configuration to a deployed configuration on the first side of the native valve, advancing the anchor in the deployed configuration from the first side of the native valve to a second side of the native valve such that the anchor is located only on the second side of the native valve, rotating the anchor in the deployed configuration around chordae of the native valve, confirming a position of the anchor with an imaging source, and releasing the anchor from the distal end of the delivery device.

Abstract: A device for treating a diseased native valve includes a frame structure having an unexpanded configuration and an expanded configuration, a plurality of leaflets coupled to the frame structure, and a spiral anchor configured to extend around the central annular portion. The frame structure in the expanded configuration includes a flared atrial portion, a central annular portion, and a flared ventricular portion. The frame structure includes a plurality of expandable cells and a plurality of paddles. Each of the paddles extends axially from a vertex of one of the plurality of expandable cells.

Abstract: A system for treating a diseased native valve in a patient includes a valve prosthesis and a delivery device. The prosthesis includes an anchor and a frame. The delivery device includes an outer sheath, an inner shaft, an anchor guide, and a tether. The anchor is shaped to encircle chordae or leaflets of a native valve. The frame is configured to sit within the anchor. The inner shaft is positioned within the outer sheath and translatable and rotatable relative to the outer sheath. The anchor guide is attached to a distal end of the inner shaft and has a curved distal section. The tether is configured to detachably couple to the anchor and to longitudinally translate the anchor within the inner shaft and anchor guide. The anchor is configured to be actuated from a delivery configuration to the deployed configuration when the anchor is translated out of the anchor guide.

Abstract: Devices, systems, and methods related to heart valve prostheses. The prosthesis includes an anchor and a frame. The anchor is shaped to encircle chordae and/or leaflets of a native heart valve. The frame is configured to sit within the anchor and the native valve such that the anchor encircles and anchors the frame in place. At least a portion of the anchor is configured to be visible using surgical visualization techniques during delivery of the prosthesis within the heart. The anchor can include an echogenic portion configured to enable viewing of the echogenic portion with ultrasound during delivery of the prosthesis.

Abstract: A device for treating a diseased native valve in a patient includes a frame structure and a valve segment coupled to the frame structure. The frame structure has an unexpanded configuration and an expanded configuration. The valve segment has a plurality of leaflets, a seal, and a seal support. An inflow edge of the plurality of leaflets is unsupported by the frame structure. The seal is attached to the inflow edge of the plurality of leaflets and positioned radially between the frame structure and the plurality of leaflets. The seal support is attached to or within the seal and provides axial rigidity to the seal.

Abstract: Systems, devices, and methods for treating a diseased native valve in a patient, the system comprising a compressible and expandable frame structure and an anchor. The anchor comprises a wire having a free end and is configured to be fully advanced from an atrial side of a native valve in a patient into a ventricle of the heart and anchor the frame structure to the native valve when the frame structure is in the expanded configuration adjacent the native valve.

Abstract: A heart valve prosthesis for replacing a diseased native valve in a patient, the valve includes an expandable frame structure and an anchor. The anchor comprises a free end and has a flat spiral shape. The anchor comprises a housing, a lumen disposed within the housing, and a plurality of spiral bands translatably disposed within the housing. The valve may further include a valve segment mounted within the frame structure and expanded with the frame structure. The frame structure may be configured for receiving a valve segment.

Abstract: A system for treating a diseased native valve in a patient includes a valve prosthesis and a delivery device. The prosthesis includes an anchor and a frame. The delivery device includes an outer sheath, an inner shaft, an anchor guide, and a tether. The anchor is shaped to encircle chordae or leaflets of a native valve. The frame is configured to sit within the anchor. The inner shaft is positioned within the outer sheath and translatable and rotatable relative to the outer sheath. The anchor guide is attached to a distal end of the inner shaft and has a curved distal section. The tether is configured to detachably couple to the anchor and to longitudinally translate the anchor within the inner shaft and anchor guide. The anchor is configured to be actuated from a delivery configuration to the deployed configuration when the anchor is translated out of the anchor guide.

Abstract: A device for treating a diseased native valve in a patient is provided, the device including a frame structure and a plurality of leaflets. The device can further include a spiral anchor configured to extend around an outer circumference of the frame structure, the spiral anchor comprising a spiral portion and a proximal portion that extends radially outwards relative to a circumference of the spiral portion. Other embodiments and methods of use are also provided.

Abstract: The present technology provides systems, devices, and methods for forming blebs to treat ocular hypertension or glaucoma. In some embodiments, a minimally invasive bleb formation device comprises an introducer sheath having a lumen extending longitudinally therethrough. The lumen has a distal end aperture insertable adjacent to a target tissue. The device further includes a wire positionable within the lumen of the introducer sheath. The wire has a first end portion, a second end portion, and an intermediate region between the first end portion and the second end portion. At least a segment of the intermediate portion is configured to extend through the distal end aperture to form a wire loop. The wire loop is moveable between a plurality of positions and is configured to disrupt and cauterize the target tissue.

Abstract: The present technology is directed to systems for treating medical conditions, such as glaucoma, and associated devices and methods. For example, in some embodiments the present technology includes an adjustable flow shunt and a sensor. When implanted in a patient, the adjustable flow shunt can be configured to fluidly couple a first body region with a second body region such that it directs the flow of fluid from the first body region to the second body region. When implanted in the patient, the sensor can measure a physiologic parameter, such as intraocular pressure. The adjustable flow shunt can be adjusted based on the measurements taken by the sensor.

Abstract: A device for treating a diseased native valve in a patient is provided, the device including a frame structure; a valve segment positioned radially within the frame structure, the valve segment comprising a plurality of leaflets, and a plurality of commissure attachment mechanisms coupling the leaflets to the frame structure, each commissure attachment mechanism extending radially inwards from an outflow end of the frame structure as to create a gap between an interior diameter of the outflow end and an outflow edge of the valve segment. Other embodiments and methods of use are also provided.

Abstract: Media content can be synchronized across multiple participant devices. A set of participant devices may request access to stream media content from a content delivery network. Each participant device can send information relating to the playback of the media content to a coordination server. The coordination server can determine a synchronized time for playback of the media content such that all participant devices playback the media content simultaneously. The coordination server can instruct each participant device to playback the media content according to the synchronized time.

Abstract: Systems, devices, and methods for treating a diseased native valve in a patient, the system comprising a compressible and expandable frame structure and an anchor. The anchor comprises a wire having a free end and is configured to be fully advanced from an atrial side of a native valve in a patient into a ventricle of the heart and anchor the frame structure to the native valve when the frame structure is in the expanded configuration adjacent the native valve.