Patents by Inventor Alicia Berger

Alicia Berger has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Probes for in vivo targeting of active cysteine proteases
    Patent number: 8343458
    Abstract: Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as 64Cu, 125I (SPECT) and 99mTc (PET). The probes show in vivo half-life and stability well suited for imaging.
    Type: Grant
    Filed: April 3, 2009
    Date of Patent: January 1, 2013
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew S. Bogyo, Galia Blum, Alicia Berger, Zhen Cheng, Sanjiv S. Gambhir
  • Probes for In Vivo Targeting of Active Cysteine Proteases
    Publication number: 20090252677
    Abstract: Activity-based probes, which are specific for certain active cysteine proteases (caspase, cathepsin and legumain) and carry radioactive labels, are disclosed. The present probes comprise an acyloxymethyketone (AOMK) “warhead” that binds only to active enzyme. The probes further comprise peptide-like structure that targets the probe to a specific cysteine protease or protease family, and a radiolabel on the probe, which is bound to the targeted enzyme. It has been found that the present probes are stable in vivo and give specific target images distinguishable over background. The preferred probes are labeled with a positron-emitting agent such as 64Cu, 125I (SPECT) and 99mTc (PET). The probes show in vivo half-life and stability well suited for imaging.
    Type: Application
    Filed: April 3, 2009
    Publication date: October 8, 2009
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Matthew S. Bogyo, Galia Blum, Alicia Berger, Zhen Cheng, Sanjiv S. Gambhir