Abstract: The present invention provides a method of forming an edible animal chew comprising the steps of (a) extruding an edible composition; followed by (b) contacting the extrudate with a plurality of post-form rollers, at least one of said post-form rollers exhibits an undulated surface and contacts the extrudate with said undulated surface, the undulated surface comprising a plurality of nodules for imparting undulations onto the extrudate surface, wherein at least some of the nodules have an elongate shape and are offset at an angle to the rotation direction of the post-form roller, said elongate shapes being oriented in two or more different directions.

Abstract: The invention provides a wound dressing material comprising a complex of an anionic polysaccharide with silver, wherein the material comprises from about 0.1 wt. % to about 3 wt. % of silver. Also provided are wound dressings comprising such materials, and the use of such materials in medicine.

Abstract: A device for detecting a mammalian host-derived enzyme in a sample of a wound fluid, said device comprising: a housing having an inlet for the sample and side walls defining a fluid flow path extending from said inlet an indicator moiety that is bound to a solid substrate by means of a peptide linker moiety that is cleavable by said host-derived enzyme, said solid substrate being located in a reaction zone of said fluid flow path; and a detector moiety located in a detection zone downstream from the reaction zone in said fluid flow path, wherein the detector moiety interacts with an indicator moiety that has been cleaved from said solid substrate to produce a detectable change in said detection zone. Suitably, the device further comprises a control moiety located in a control zone in said device, wherein the control moiety can interact with a component of the wound fluid sample to improve the accuracy of the device.

Abstract: A method of forming a polyurethane foam suitable for use as a wound-contacting layer, said method comprising: mixing 1 part by weight of an isocyanate-capped prepolymer having from 0.5 to 1.2 meq NCO groups/g with from 0.4 to 1.0 parts by weight of water in the presence of from 0.05 to 0.4 parts by weight of a C1 to C3 monohydric alcohol to form a foamed product; followed by treating the foamed product with a dispersion of a therapeutic agent and drying the treated foamed product. Also provided are medicated polyurethane foams obtainable by the method of the invention, and wound dressings comprising such foams.

Abstract: The invention provides a wound dressing material comprising a complex of an anionic polysaccharide with silver, wherein the material comprises from about 0.1 wt. % to about 3 wt. % of silver. Also provided are wound dressings comprising such materials, and the use of such materials in medicine.

Abstract: A wound treatment device comprising a water-impermeable envelope having at least one aperture, wherein the envelope contains a therapeutic substance, and wherein the at least one aperture in the envelope is blocked by a material that breaks down in the presence of one or more active components of wound fluid thereby permitting the therapeutic substance to contact the wound fluid. Preferably, the aperture is blocked by a material that is a substrate for an enzyme present in wound fluid, such as a protease.