Abstract: The present invention relates to oral care composition comprising a zinc salt having a solubility in water higher than 3.0·104 mg/L at 25° C., an isopropylmethylphenol compound, a glycyrrhizin derivative and water, as well as to their use in oral care, in particular for the treatment and/or prevention of dental plaque formation, caries formation, calculus formation, halitosis, gingivitis, periodontitis, peri-implant mucositis and/or periimplantitis.

Abstract: Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I) in which A and B independently represent any of the groups —ONO2 and —Z—CO—R, wherein Z is an oxygen atom or sulphur atom and R is an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, or the group in which R1 is hydrogen, or an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, with the proviso that one of A or B is always —ONO2, but never both of them at the same time, when Z is an sulphur atom R is an alkyl C1-C4 group, an aryl group or an aralkyl group, eventually substituted, and when Z is an oxygen atom R is the group

Abstract: The present invention is directed to a S-nitrosothiol derivative of penicillamine or glutathione, of formula I: or its pharmaceutically acceptable salt thereof, in which: A and B are independently phenyl groups or together form the group —CH2—Q—CH2—constituting a six membered ring in which Q represents oxygen, sulfur, or a group N—R3, in which R3 is hydrogen or a C1-C4 alkyl group; R1 is an acyl group, which may be an aliphatic C1-C5 acyl group or an acyl group of glutamic acid bonded via its gamma carboxyl group; R2 is a hydroxyl group or a glycine group bonded via a peptide bond; with the proviso that if R1 is an aliphatic acyl group, then R2 is a hydroxyl group, and if R1 is a glutamic acid, then R2 is a glycine group. The compounds have vasodilating activity and inhibit the aggregation of the platelets which make them useful for the treatment of dysfunctions of the circulating system, especially at the cardiovascular level.

Abstract: Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I) 1

Abstract: Novel S-nitrosothiols derivatives of penicillamine or glutathione, which correspond to following general formula(I) 1

Abstract: Novel derivatives of isosorbide mononitrate and its pharmaceutically acceptable salts, which have vasodilating activity with a reduced effect of tolerance, of the general formula (I) 1