Patents by Inventor Alicia Megia-Fernandez

Alicia Megia-Fernandez has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Optical probes for matrix metalloproteinases
    Patent number: 10507247
    Abstract: An optical probe is presented comprising at least one fluorophore connected to at least one quencher by an enzyme cleavable peptide sequence; the or each fluorophore being substantially fluorescently quenched by the at least one quencher when connected to the enzyme cleavable peptide sequence; the or each fluorophore is separated from the at least one quencher when the enzyme cleavable peptide sequence of the at least one probe element is cleaved; and the enzyme cleavable peptide sequence is selectively cleavable by one or more matrix metalloproteinase (MMP). Methods of use of the optical probe are also presented.
    Type: Grant
    Filed: March 18, 2016
    Date of Patent: December 17, 2019
    Assignee: The University of the University of Edinburgh
    Inventors: Mark Bradley, Sunay Vijaykumar Chankeshwara, Alicia Megia-Fernandez
  • OPTICAL PROBES FOR MATRIX METALLOPROTEINASES
    Publication number: 20180085466
    Abstract: An optical probe is presented comprising at least one fluorophore connected to at least one quencher by an enzyme cleavable peptide sequence; the or each fluorophore being substantially fluorescently quenched by the at least one quencher when connected to the enzyme cleavable peptide sequence; the or each fluorophore is separated from the at least one quencher when the enzyme cleavable peptide sequence of the at least one probe element is cleaved; and the enzyme cleavable peptide sequence is selectively cleavable by one or more matrix metalloproteinase (MMP). Methods of use of the optical probe are also presented.
    Type: Application
    Filed: March 18, 2016
    Publication date: March 29, 2018
    Inventors: Mark Bradley, Sunay Vijaykumar Chankeshwara, Alicia Megia-Fernandez