Abstract: A computer-implemented method and system are described for conducting an adaptive clinical trial at a plurality of geographically remote sites. The invention includes (1) collecting performance metric data from remote clinical sites; (2) processing, tracking, and validating such data at a processing location; (3) electronically reporting the data to a pre-programmed computer module; (4) determining in real time, by use of the pre-programmed computer module, whether procedures or parameters utilized in conducting the clinical trial require modification; (5) providing instructions, based on such determining, to modify the procedures or parameters utilized in conducting the clinical trial; and (6) modifying the procedures or parameters utilized in conducting the clinical trial, based on the applicable instructions.