Patents by Inventor Alipasha Vaziri
Alipasha Vaziri has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11808702Abstract: A multi-photon imaging system includes a laser module having a first channel for outputting a two-photon excitation laser pulse and a second channel for outputting a three-photon excitation laser pulse. The system further includes a first optical path for guiding the two-photon laser pulse from the first channel of the laser module and a second optical path for guiding the three-photon laser pulse from the second channel of the laser module. A microscope is also provided for simultaneously receiving the two-photon laser pulse from the first optical path and the three-photon laser pulse from the second optical path, and simultaneously, or with well controllable delays, delivering the two-photon laser pulse and the three-photon pulse to a target volume. The system further includes a photodetector configured to collect photons generated within the target volume in response to simultaneous excitation of the target volume by both the two-photon laser pulse and the three-photon laser pulse.Type: GrantFiled: January 30, 2020Date of Patent: November 7, 2023Assignee: The Rockefeller UniversityInventors: Alipasha Vaziri, Siegfried Weisenburger
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Publication number: 20230152561Abstract: A multiplexing module provided herein is configured to perform operations of receiving a plurality of laser pulses from a pulsed laser source; splitting each laser pulse into a plurality of beamlets; introducing a delay between each adjacent beamlet of the plurality of beamlets, such that the plurality of beamlets associated with a respective laser pulse of the plurality of laser pulses is distributed equally across a pulse repetition period associated with the pulsed laser source; changing a divergence of each subsequent beamlet of the plurality of beamlets associated with each respective laser pulse to introduce a distinguishing feature between each beamlet of the plurality of beamlet to cause each beamlet to focus on a different axial plane or lateral position of the sample; and outputting the plurality of beamlets associated with each respective laser pulse.Type: ApplicationFiled: January 31, 2021Publication date: May 18, 2023Applicant: The Rockefeller UniversityInventors: Alipasha VAZIRI, Jeffrey Dakin DEMAS
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Publication number: 20220120686Abstract: A multi-photon imaging system includes a laser module having a first channel for outputting a two-photon excitation laser pulse and a second channel for outputting a three-photon excitation laser pulse. The system further includes a first optical path for guiding the two-photon laser pulse from the first channel of the laser module and a second optical path for guiding the three-photon laser pulse from the second channel of the laser module. A microscope is also provided for simultaneously receiving the two-photon laser pulse from the first optical path and the three-photon laser pulse from the second optical path, and simultaneously, or with well controllable delays, delivering the two-photon laser pulse and the three-photon pulse to a target volume. The system further includes a photodetector configured to collect photons generated within the target volume in response to simultaneous excitation of the target volume by both the two-photon laser pulse and the three-photon laser pulse.Type: ApplicationFiled: January 30, 2020Publication date: April 21, 2022Applicant: The Rockefeller UniversityInventors: Alipasha VAZIRI, Siegfried WEISENBURGER
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Patent number: 11255837Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.Type: GrantFiled: May 24, 2019Date of Patent: February 22, 2022Assignee: UNIVERSITY OF VIENNAInventors: Alipasha Vaziri, Robert Prevedel
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Patent number: 11199691Abstract: An imaging signal extraction apparatus comprising: an interface; a processing device, the processing device operatively coupled to the interface; and a computer readable medium comprising instructions that, when executed by the processing device, perform operations comprising: a) generating a two-dimensional image from imaging information obtained from the interface, thereby estimating ballistic component of the imaging information; b) generating a three-dimensional image by remapping the two-dimensional image; c) identifying a candidate object in the three-dimensional image; d) obtaining an estimated spatial forward model of the candidate object by mapping the three-dimensional image of the candidate object with a point-spread-function associated with the imaging apparatus; e) obtaining background-corrected data by using the estimated spatial forward model of the candidate object and estimated temporal components; and f) iteratively updating the estimated spatial forward model and estimated temporal componenType: GrantFiled: October 7, 2020Date of Patent: December 14, 2021Assignee: The Rockefeller UniversityInventors: Alipasha Vaziri, Tobias Noebauer, Oliver Skocek
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Publication number: 20210033843Abstract: An imaging signal extraction apparatus comprising: an interface; a processing device, the processing device operatively coupled to the interface; and a computer readable medium comprising instructions that, when executed by the processing device, perform operations comprising: a) generating a two-dimensional image from imaging information obtained from the interface, thereby estimating ballistic component of the imaging information; b) generating a three-dimensional image by remapping the two-dimensional image; c) identifying a candidate object in the three-dimensional image; d) obtaining an estimated spatial forward model of the candidate object by mapping the three-dimensional image of the candidate object with a point-spread-function associated with the imaging apparatus; e) obtaining background-corrected data by using the estimated spatial forward model of the candidate object and estimated temporal components; and f) iteratively updating the estimated spatial forward model and estimated temporal componenType: ApplicationFiled: October 7, 2020Publication date: February 4, 2021Applicant: The Rockefeller UniversityInventors: Alipasha Vaziri, Tobias NOEBAUER, Oliver SKOCEK
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Patent number: 10802263Abstract: An imaging signal extraction apparatus comprising: an interface; a processing device, the processing device operatively coupled to the interface; and a computer readable medium comprising instructions that, when executed by the processing device, perform operations comprising: a) generating a two-dimensional image from imaging information obtained from the interface, thereby estimating ballistic component of the imaging information; b) generating a three-dimensional image by remapping the two-dimensional image; c) identifying a candidate object in the three-dimensional image; d) obtaining an estimated spatial forward model of the candidate object by mapping the three-dimensional image of the candidate object with a point-spread-function associated with the imaging apparatus; e) obtaining background-corrected data by using the estimated spatial forward model of the candidate object and estimated temporal components; and f) iteratively updating the estimated spatial forward model and estimated temporal componenType: GrantFiled: May 18, 2018Date of Patent: October 13, 2020Assignee: The Rockefeller UniversityInventors: Alipasha Vaziri, Tobias Noebauer, Oliver Skocek
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Publication number: 20200201018Abstract: An imaging signal extraction apparatus comprising: an interface; a processing device, the processing device operatively coupled to the interface; and a computer readable medium comprising instructions that, when executed by the processing device, perform operations comprising: a) generating a two-dimensional image from imaging information obtained from the interface, thereby estimating ballistic component of the imaging information; b) generating a three-dimensional image by remapping the two-dimensional image; c) identifying a candidate object in the three-dimensional image; d) obtaining an estimated spatial forward model of the candidate object by mapping the three-dimensional image of the candidate object with a point-spread-function associated with the imaging apparatus; e) obtaining background-corrected data by using the estimated spatial forward model of the candidate object and estimated temporal components; and f) iteratively updating the estimated spatial forward model and estimated temporal componenType: ApplicationFiled: May 18, 2018Publication date: June 25, 2020Inventors: Alipasha Vaziri, Tobias Noebauer, Oliver SKOCEK
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Publication number: 20200182792Abstract: A tissue imaging system includes a laser module for outputting a laser pulse, an optical delay module configured to split a laser pulse received from the laser module into a plurality of time-delayed sub-pulses, a telescope for delivering the sub-pulses from the optical delay module to a target volume and a photodetector configured to collect photons generated within the target volume in response to excitation of the target volume by the first and second sub-pulses. The system may further include a spatial multiplexing module configured to receive the temporally multiplexed laser pulse from the optical delay module and splitting the temporally multiplexed laser pulse into a plurality of sub-beams including a first sub-beam and a second sub-beam, wherein the first sub-beam and the second sub-beam are spatially separated with respect to a first image plane formed at a first depth within the target volume and with respect to a second image plane formed at a second depth within the target volume.Type: ApplicationFiled: October 30, 2017Publication date: June 11, 2020Inventor: Alipasha Vaziri
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Publication number: 20190277827Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.Type: ApplicationFiled: May 24, 2019Publication date: September 12, 2019Inventors: Alipasha Vaziri, Robert Prevedel
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Patent number: 10317390Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.Type: GrantFiled: September 7, 2015Date of Patent: June 11, 2019Assignee: UNIVERSITY OF VIENNAInventors: Alipasha Vaziri, Robert Prevedel
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Patent number: 9952422Abstract: Methods and systems are provided for enhancing the imaging resolution of three dimensional imaging using light field microscopy. A first approach enhances the imaging resolution by modeling the scattering of light that occurs in an imaging target, and using the model to account for the effects of light scattering when de-convolving the light field information to retrieve the 3-dimensional (3D) volumetric information of the imaging target. A second approach enhances the imaging resolution by using a second imaging modality such as two-photon, multi-photon, or confocal excitation microscopy to determine the locations of individual neurons, and using the known neuron locations to enhance the extraction of time series signals from the light field microscopy data.Type: GrantFiled: January 14, 2016Date of Patent: April 24, 2018Assignee: UNIVERSITY OF VIENNAInventors: Alipasha Vaziri, Tobias Nöbauer
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Publication number: 20170205615Abstract: Methods and systems are provided for enhancing the imaging resolution of three dimensional imaging using light field microscopy. A first approach enhances the imaging resolution by modeling the scattering of light that occurs in an imaging target, and using the model to account for the effects of light scattering when de-convolving the light field information to retrieve the 3-dimensional (3D) volumetric information of the imaging target. A second approach enhances the imaging resolution by using a second imaging modality such as two-photon, multi-photon, or confocal excitation microscopy to determine the locations of individual neurons, and using the known neuron locations to enhance the extraction of time series signals from the light field microscopy data.Type: ApplicationFiled: January 14, 2016Publication date: July 20, 2017Inventors: Alipasha VAZIRI, Tobias NĂ–BAUER
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Publication number: 20160069794Abstract: Devices and methods for recording dynamics of cellular and/or biochemical processes, including a device including one or more dispersive elements configured to receive a pulsed laser beam with a spectrum of different wavelengths and disperse the spectrum of the pulsed laser beam; and one or more first elements configured to receive the dispersed spectrum of the pulsed laser beam, and generate a multiphoton excitation area in a biological sample by re-overlapping in time and space the dispersed spectrum of the pulsed laser beam on an area in the biological sample, wherein the device is configured to record at high speed changes of cellular and biochemical processes of a population of cells of the biological sample based on generation of the multiphoton excitation area in the biological sample.Type: ApplicationFiled: September 7, 2015Publication date: March 10, 2016Applicant: UNIVERSITY OF VIENNAInventors: Alipasha Vaziri, Robert Prevedel
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Patent number: 8064059Abstract: An apparatus includes a delay producing system that receives a parent electromagnetic pulse and outputs two spatially-overlapped children electromagnetic pulses having a relative and adjustable time delay between each other; a fluorescence producing device placed in a path of the children electromagnetic pulses; a guidance system that is in the path of the children pulses and is positioned between the delay producing system and the fluorescence producing device to guide the children pulses to the fluorescence producing device; a detector that receives fluorescence produced at the fluorescence producing device, where the fluorescence travels at least partly through the guidance system before reaching the detector; and a data system that receives the value of the time delay and the output of the detector and determines the electromagnetic pulse duration based on the value of the time delay and the output of the detector.Type: GrantFiled: November 4, 2008Date of Patent: November 22, 2011Inventor: Alipasha Vaziri
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Publication number: 20100110440Abstract: An apparatus includes a delay producing system that receives a parent electromagnetic pulse and outputs two spatially-overlapped children electromagnetic pulses having a relative and adjustable time delay between each other; a fluorescence producing device placed in a path of the children electromagnetic pulses; a guidance system that is in the path of the children pulses and is positioned between the delay producing system and the fluorescence producing device to guide the children pulses to the fluorescence producing device; a detector that receives fluorescence produced at the fluorescence producing device, where the fluorescence travels at least partly through the guidance system before reaching the detector; and a data system that receives the value of the time delay and the output of the detector and determines the electromagnetic pulse duration based on the value of the time delay and the output of the detector.Type: ApplicationFiled: November 4, 2008Publication date: May 6, 2010Applicant: Howard Hughes Medical InstituteInventor: Alipasha Vaziri