Abstract: A wound closure system includes a porous mesh, a first pressure sensitive adhesive (PSA) applied to a top surface of the porous mesh, a removable first liner covering the first PSA, a second PSA applied to a bottom surface of the porous mesh, and a removable second liner covering the second PSA. The second PSA is stronger or denser than the first PSA. A method of using the wound closure system includes removing the second liner to expose the second PSA, pressing the second PSA against skin to approximate wound edges, removing the first liner to expose the first PSA, and pressing a therapeutic device against the first PSA to secure the therapeutic device to the porous mesh. A liquid adhesive is applied over the porous mesh and the therapeutic device, and then cured for binding the porous mesh to skin and binding the therapeutic device to the porous mesh.