Abstract: The disclosure is directed towards chemical compositions and methods for treatment of pain, including osteoarthritic pain. The compositions comprise a group of TRPV1 ion channel modulator derivatives, including capsaicinoid derivatives, which are capable of covalently linking to a polymer. The disclosed TRPV1 ion channel modulator derivatives are covalently linked to a polymer and alternatively or additionally said ion channel modulator derivatives are mixed with the polymer. Also disclosed are methods for treatment of pain using the disclosed compounds via injection to a location of the pain or to a vicinity of the location of pain. The disclosed compositions and methods are advantageous because they exhibit sustained release of TRPV1 ion channel modulators, attenuation of initial acute pain associated with TRPV1 modulators, and an ability to be used in high concentrations, thereby resulting in efficacious treatment of pain, including osteoarthritic knee joint pain.

Abstract: Compositions and methods for providing sustained and long lasting release of ion channel modulators as analgesics are provided. The compositions comprise a carrier, and a polymer covalently linked to at least one class of ion channel modulators. The ion channel modulators are selected from the group consisting of modulators of transient receptor potential cation channel subfamily V member 1 (TRPV1) channels, voltage gated sodium (Nav) channels, voltage gated calcium (Cav) channels, and combinations thereof. The polymers in the compositions are biocompatible, for example hyaluronic acid or polyethylene glycol. The covalent bond between the ion channel modulator and the polymer may be direct or via a linker. The compositions of this disclosure can be administered as injections locally. The compositions of this invention provide pain relief with a reduced initial acute period of sensitisation when applied to pain sensing neurons.

Abstract: The invention relates to a peptide drug for use as a localized antimicrobial agent and/or in the localised modulation of nerve cell activity, cardiomyocyte or muscle cell electrical activity in a subject, wherein the peptide drug comprises a polymer in a carrier, and further comprising: i) a plurality of cationic peptides, or an amino acid monomer thereof, covalently bound to the polymer; and/or ii) a plurality of cationic peptides, or an amino acid monomer thereof, mixed with the polymer. The invention further relates to the use of CARPs for use in the localised modulation of nerve cell activity, cardiomyocyte or muscle cell electrical activity in a subject. The invention further relates to modulation of chondrocyte function.

Abstract: A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.

Abstract: A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.

Abstract: A cell collection device having an elongated member and a mesh disposed about the elongated member. The mesh has a low energy expanded state and a high energy compressed state. A sheath is disposed about a distal end of the elongated member and is slidable along the elongated member from a first position in which the sheath radially constrains the mesh to the high energy compressed state and a second position in which the sheath does not constrain the mesh.

Abstract: A prosthesis and a method of controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a first valve and a second valve operably connected to the body. The first valve has a proximal portion, a distal portion, a distal end extending distally relative to the proximal portion of the body and a lumen extending through the first valve. The first valve is closed in the absence of a second and third pressure that are greater than a first pressure. The second valve has a proximal portion, a distal portion, a distal end extending distally relative to a proximal portion of the body and a lumen extending through the second valve, the distal end of the first valve extending distal to the distal end of the second valve.

Abstract: A prosthesis and a method for making a prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough and further includes a valve operably connected to the body. The valve has a distal end including a first portion of a surface of the valve lumen and a second portion of the surface that contact each other and form a seal in a closed configuration. The distal end of the valve is formed such that the first portion and the second portion of the surface of the valve lumen contact each other and the distal end is configured to open in response to a pressure that is greater than atmospheric pressure.

Abstract: Implantable medical devices are described. For example, various implantable medical devices having a sleeve with differential wall thicknesses are described. An exemplary medical device comprises a frame and a sleeve that has a first configuration where the sleeve is in an extended position and a second configuration where the sleeve is in an inverted position.

Abstract: A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.

Abstract: A prosthesis and a method for making a prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough and further includes a valve operably connected to the body. The valve has a distal end including a first portion of a surface of the valve lumen and a second portion of the surface that contact each other and form a seal in a closed configuration. The distal end of the valve is formed such that the first portion and the second portion of the surface of the valve lumen contact each other and the distal end is configured to open in response to a pressure that is greater than atmospheric pressure.

Abstract: A medical device for collecting cells includes an inflatable balloon and a perforated sleeve surrounding the balloon. The sleeve includes a plurality of openings therein for collecting cells when inserted into a body cavity. The balloon and sleeve can be housed in a sheath in a compressed delivery condition for being delivered to a target site for cell collection. The balloon and sleeve can then be inflated to expand into contact with the target site. The openings in the sleeve create a mildly abrasive surface for enhancing cell collection while limiting patient trauma. The balloon and sleeve can be reciprocated back and forth to collect cells from the surface of the body cavity. The balloon and sleeve having the collected cells can then be deflated and retracted from the body cavity.

Abstract: A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.

Abstract: A cell collection device having an elongated member and a mesh disposed about the elongated member. The mesh has a low energy expanded state and a high energy compressed state. A sheath is disposed about a distal end of the elongated member and is slidable along the elongated member from a first position in which the sheath radially constrains the mesh to the high energy compressed state and a second position in which the sheath does not constrain the mesh.

Abstract: A medical device for collecting cells includes an inflatable balloon and a perforated sleeve surrounding the balloon. The sleeve includes a plurality of openings therein for collecting cells when inserted into a body cavity. The balloon and sleeve can be housed in a sheath in a compressed delivery condition for being delivered to a target site for cell collection. The balloon and sleeve can then be inflated to expand into contact with the target site. The openings in the sleeve create a mildly abrasive surface for enhancing cell collection while limiting patient trauma. The balloon and sleeve can be reciprocated back and forth to collect cells from the surface of the body cavity. The balloon and sleeve having the collected cells can then be deflated and retracted from the body cavity.

Abstract: A prosthesis and a method of controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a first valve and a second valve operably connected to the body. The first valve has a proximal portion, a distal portion, a distal end extending distally relative to the proximal portion of the body and a lumen extending through the first valve. The first valve is dosed in the absence of a second and third pressure that are greater than a first pressure. The second valve has a proximal portion, a distal portion, a distal end extending distally relative to a proximal portion of the body and a lumen extending through the second valve, the distal end of the first valve extending distal to the distal end of the second valve.

Abstract: Implantable medical devices are described. For example, various implantable medical devices having a sleeve with differential wall thicknesses are described. An exemplary medical device comprises a frame and a sleeve that has a first configuration where the sleeve is in an extended position and a second configuration where the sleeve is in an inverted position.

Abstract: A prosthesis and a method of manufacturing the prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough. The prosthesis also includes a valve operably connected to the body. The valve has a proximal portion, a distal portion and a lumen extending through the valve, where the valve lumen is connected to the body lumen. The valve is configured to be closed in the absence of an antegrade pressure and a retrograde pressure, the retrograde pressure being greater than the antegrade pressure. The valve includes a material portion operably connected to the valve, the material portion providing increased stiffness to the valve relative to the valve alone, wherein the material portion is configured to facilitate self-reversion of the valve to the closed configuration.

Abstract: A prosthesis and a method for making a prosthesis for controlling flow through a bodily lumen are provided. The prosthesis includes a body having a proximal portion, a distal portion and a lumen extending therethrough and further includes a valve operably connected to the body. The valve has a distal end including a first portion of a surface of the valve lumen and a second portion of the surface that contact each other and form a seal in a closed configuration. The distal end of the valve is formed such that the first portion and the second portion of the surface of the valve lumen contact each other and the distal end is configured to open in response to a pressure that is greater than atmospheric pressure.

Abstract: A prosthesis for placement within a body vessel of a patient may include a tubular frame and a covering material coupled to the tubular frame. The covering material may have an outer surface defining at least a segment of an outer surface of the prosthesis. An anti-migration coating may be applied to at least a portion of the outer surface of the prosthesis. The anti-migration coating may include a mucoadhesive agent. The mucoadhesive agent may include a polymer configured to adhere to a mucous membrane within the body vessel. The anti-migration coating may have a thickness of greater than or equal to about 2 ?m in a dry state to promote adhesion to the mucous membrane.