Patents by Inventor ALISON LING
ALISON LING has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11786637Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: March 1, 2021Date of Patent: October 17, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 11375710Abstract: A tissue graft container is provided having an interior space and including a vent which allows fluid (liquid and vapor) to escape from the container during drying of the tissue graft. The vent may be one or more apertures, one or more elongated openings, or a combination thereof, through one or more components of the container. A tissue graft packaging system having a retainer including first and second members with respective first and second pluralities of channels, and configured to removeably interconnect the first and second members in a closed configuration. The first and second pluralities of channels create a continuous interior space. The retainer further includes a vent, such as apertures, slits, etc., through one or both of the first and second retainers, for allowing moisture to escape from the retainer during the drying of a tissue graft contained within the continuous interior space of the retainer.Type: GrantFiled: June 17, 2020Date of Patent: July 5, 2022Assignee: Musculoskeletal Transplant FoundationInventors: Kevin Wu, Elizabeth Ann Poyss, Todd Nilsen, Alison Ling
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Publication number: 20210178022Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli comprising simulated hypoxia to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: ApplicationFiled: March 1, 2021Publication date: June 17, 2021Inventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 10973953Abstract: Methods and compositions for preparing and priming a tissue graft for an accelerated therapeutic effect are provided herein. In one embodiment, the method includes obtaining a tissue containing viable cells from a donor, wherein the viable cells are endogenous to the tissue and remain resident in the tissue; and priming the viable cells with one or more stimuli to produce a primed tissue, wherein when grafted to a recipient the primed tissue provides a benefit compared to non-primed tissue.Type: GrantFiled: August 17, 2017Date of Patent: April 13, 2021Assignee: Musculoskeletal Transplant FoundationInventors: Eric Semler, Mark Spilker, Kevin Wu, Yen-Chen Huang, Evangelia Chnari, Jeffrey Cartmell, Morris Jacobs, Alison Ling, Moon Hae Sunwoo
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Patent number: 10828141Abstract: A medical implant packaging assembly having an outer tray, an inner tray and a retainer. An implant which may include a hydrated tissue graft may be positioned within the packaging assembly. The inner tray is formed from a moisture barrier material whereby the implant may be maintained in a hydrated state, even if the implant is not immersed in fluid within the packaging assembly, thereby avoiding need for rehydrating steps that are required for dehydrated and/or cryopreserved implants prior to or during surgery. The outer tray and inner tray and a retainer are also made of transparent materials, enabling medical personnel to view the implant through these packaging components prior to and during surgery.Type: GrantFiled: February 5, 2020Date of Patent: November 10, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Jeffrey Kapec, Jacob Turetsky, Yukiko Naoi, Alison Ling, German Eduardo Jurado Rivera, Darrin Friend, Morris Jacobs
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Publication number: 20200305418Abstract: A tissue graft container is provided having an interior space and including a vent which allows fluid (liquid and vapor) to escape from the container during drying of the tissue graft. The vent may be one or more apertures, one or more elongated openings, or a combination thereof, through one or more components of the container. A tissue graft packaging system having a retainer including first and second members with respective first and second pluralities of channels, and configured to removeably interconnect the first and second members in a closed configuration. The first and second pluralities of channels create a continuous interior space. The retainer further includes a vent, such as apertures, slits, etc., through one or both of the first and second retainers, for allowing moisture to escape from the retainer during the drying of a tissue graft contained within the continuous interior space of the retainer.Type: ApplicationFiled: June 17, 2020Publication date: October 1, 2020Inventors: Kevin Wu, Elizabeth Ann Poyss, Todd Nilsen, Alison Ling
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Patent number: 10695157Abstract: A tissue graft packaging system having a retainer including first and second members with respective first and second pluralities of channel sidewalls that define first and second pluralities of channels, and first and second engagement means configured to removeably interconnect the first and second members. The first and second pluralities of channel sidewalls are configured to create a continuous interior space between the first and second members. A tissue graft, such as a cryopreserved viable tissue graft, is contained within the continuous interior space of the retainer. Processes for packaging, thawing and rinsing the tissue graft using the tissue graft packaging system and its retainer are also disclosed.Type: GrantFiled: January 10, 2017Date of Patent: June 30, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Elizabeth Ann Poyss, Todd J. Nilsen, Alison Ling, Kevin Wu
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Publication number: 20200170772Abstract: A medical implant packaging assembly having an outer tray, an inner tray and a retainer. An implant which may include a hydrated tissue graft may be positioned within the packaging assembly. The inner tray is formed from a moisture barrier material whereby the implant may be maintained in a hydrated state, even if the implant is not immersed in fluid within the packaging assembly, thereby avoiding need for rehydrating steps that are required for dehydrated and/or cryopreserved implants prior to or during surgery. The outer tray and inner tray and a retainer are also made of transparent materials, enabling medical personnel to view the implant through these packaging components prior to and during surgery.Type: ApplicationFiled: February 5, 2020Publication date: June 4, 2020Inventors: Jeffrey Kapec, Jacob Turetsky, Yukiko Naoi, Alison Ling, German Eduardo Jurado Rivera, Darrin Friend, Morris Jacobs
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Patent number: 10582994Abstract: A medical implant packaging assembly having an outer tray, an inner tray and a retainer The implant may include a tissue graft. The inner tray is formed from a moisture barrier material whereby the implant may be maintained in a hydrated state, thereby avoiding need for rehydrating steps that are required for dehydrated or cryopreserved implants. The outer tray and inner tray and a retainer are also made of transparent materials, enabling medical personnel to view the implant through these packaging components prior to and during surgery.Type: GrantFiled: March 6, 2018Date of Patent: March 10, 2020Assignee: Musculoskeletal Transplant FoundationInventors: Jeffrey Kapec, Jacob Turetsky, Yukiko Naoi, Alison Ling, German Eduardo Jurado Rivera, Darrin Friend, Morris Jacobs
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Publication number: 20190274809Abstract: A medical implant packaging assembly having an outer tray, an inner tray and a retainer The implant may include a tissue graft. The inner tray is formed from a moisture barrier material whereby the implant may be maintained in a hydrated state, thereby avoiding need for rehydrating steps that are required for dehydrated or cryopreserved implants. The outer tray and inner tray and a retainer are also made of transparent materials, enabling medical personnel to view the implant through these packaging components prior to and during surgery.Type: ApplicationFiled: March 6, 2018Publication date: September 12, 2019Inventors: Jeffrey Kapec, Jacob Turetsky, Yukiko Naoi, Alison Ling, German Eduardo Jurado Rivera, Darrin Friend, Morris Jacobs
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Publication number: 20180193127Abstract: A tissue graft packaging system having a retainer including first and second members with respective first and second pluralities of channel sidewalls that define first and second pluralities of channels, and first and second engagement means configured to removeably interconnect the first and second members. The first and second pluralities of channel sidewalls are configured to create a continuous interior space between the first and second members. A tissue graft, such as a cryopreserved viable tissue graft, is contained within the continuous interior space of the retainer. Processes for packaging, thawing and rinsing the tissue graft using the tissue graft packaging system and its retainer are also disclosed.Type: ApplicationFiled: January 10, 2017Publication date: July 12, 2018Inventors: Elizabeth Ann Poyss, Todd J. Nilsen, Alison Ling
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Patent number: 9924723Abstract: The present invention provides concrete-containing compositions, and methods of making and using the same, that allow for the prevention of microbially induced corrosion in concrete. In certain embodiments, the concrete-containing compositions comprise a cementitious substrate, and a formulation of heavy metal-laden, carbon-based sorbent.Type: GrantFiled: November 11, 2014Date of Patent: March 27, 2018Assignee: The Regents of the University of Colorado, a body corporateInventors: Mark Hernandez, Alison Ling
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Publication number: 20160286818Abstract: The present invention provides concrete-containing compositions, and methods of making and using the same, that allow for the prevention of microbially induced corrosion in concrete. In certain embodiments, the concrete-containing compositions comprise a cementitious substrate, and a formulation of heavy metal-laden, carbon-based sorbent.Type: ApplicationFiled: November 11, 2014Publication date: October 6, 2016Inventors: MARK HERNANDEZ, ALISON LING
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Patent number: D832457Type: GrantFiled: January 10, 2017Date of Patent: October 30, 2018Assignee: Musculoskeletal Transplant FoundationInventors: Elizabeth Ann Poyss, Todd J. Nilsen, Alison Ling, Kevin Wu
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Patent number: D864414Type: GrantFiled: October 3, 2017Date of Patent: October 22, 2019Assignee: Musculoskeletal Transplant FoundationInventors: Elizabeth Ann Poyss, Todd J. Nilsen, Alison Ling, Kevin Wu
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Patent number: D954993Type: GrantFiled: June 17, 2020Date of Patent: June 14, 2022Assignee: Musculoskeletal Transplant FoundationInventors: Kevin Wu, Elizabeth Ann Poyss, Todd Nilsen, Alison Ling
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Patent number: D1001311Type: GrantFiled: January 5, 2022Date of Patent: October 10, 2023Assignee: Musculoskeletal Transplant FoundationInventors: Kevin Wu, Elizabeth Ann Poyss, Todd Nilsen, Alison Ling