Patents by Inventor Alison M. Goate

Alison M. Goate has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sequences associated with TDP-43 proteinopathies and methods of using the same
    Patent number: 10683544
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
    Type: Grant
    Filed: November 8, 2016
    Date of Patent: June 16, 2020
    Assignee: Washington University
    Inventors: Nigel J. Cairns, Robert H. Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • SEQUENCES ASSOCIATED WITH TDP-43 PROTEINOPATHIES AND METHODS OF USING THE SAME
    Publication number: 20170067112
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
    Type: Application
    Filed: November 8, 2016
    Publication date: March 9, 2017
    Inventors: Nigel J. Cairns, Robert H. Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • Sequences associated with TDP-43 proteinopathies and methods of using the same
    Patent number: 9523128
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
    Type: Grant
    Filed: October 14, 2014
    Date of Patent: December 20, 2016
    Assignee: WASHINGTON UNIVERSITY
    Inventors: Nigel J. Cairns, Robert H. Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • SEQUENCES ASSOCIATED WITH TDP-43 PROTEINOPATHIES AND METHODS OF USING THE SAME
    Publication number: 20150065384
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an array comprising the nucleic acids and peptides of the invention.
    Type: Application
    Filed: October 14, 2014
    Publication date: March 5, 2015
    Inventors: Nigel J. Cairns, Robert H. Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • Sequences associated with TDP-43 proteinopathies and methods of using the same
    Patent number: 8889597
    Abstract: The present invention provides nucleic acids and peptides, and methods of using the nucleic acids and peptides to identify subjects at risk for a TDP-43 proteinopathy. The invention also provides for an army comprising the nucleic acids and peptides of the invention.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: November 18, 2014
    Assignee: Washington University
    Inventors: Nigel J. Cairns, Robert H Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • Markers for addiction
    Patent number: 8080371
    Abstract: Correlations between polymorphisms and addiction are provided. Methods of diagnosing, prognosing, and treating addiction are provided. Systems and kits for diagnosis, prognosis and treatment of addiction are provided. Methods of identifying addiction modulators are also described.
    Type: Grant
    Filed: March 1, 2007
    Date of Patent: December 20, 2011
    Assignee: The Washington University
    Inventors: Dennis Ballinger, Karel Konvicka, Laura Jean Bierut, John Rice, Frank Scott Saccone, Anthony L. Hinrichs, Alison M. Goate, Jen Wang
  • GENETIC POLYMORPHISMS AND SUBSTANCE DEPENDENCE
    Publication number: 20110143344
    Abstract: The invention encompasses methods for identifying subjects at risk for substance dependence by detecting the presence of polymorphism in the CHRNA5-CHRNA3-CHRNB4 gene cluster and the CHRNA4 gene. The invention also encompasses determining the response of a subject to a therapeutic substance, treating substance dependence in a subject, and evaluating the response of a subject to a substance cessation treatment.
    Type: Application
    Filed: November 29, 2010
    Publication date: June 16, 2011
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Alison M. Goate, Laura J. Bierut, Jen-Chyong C. Wang
  • SEQUENCES ASSOCIATED WITH TDP-43 PROTEINOPATHIES AND METHODS OF USING THE SAME
    Publication number: 20110065600
    Abstract: Nucleic acids and peptides and methods of using thereof to identify subjects at risk for a TDP-43 proteinopathy are disclosed An array is also disclosed which contains the nucleic acids and peptides
    Type: Application
    Filed: January 30, 2009
    Publication date: March 17, 2011
    Applicant: THE WASHINGTON UNIVERSITY
    Inventors: Niegel J. Cairns, Robert H Baloh, Alan Pestronk, Michael A. Gitcho, Alison M. Goate
  • GENETIC POLYMORPHISMS AND SUBSTANCE DEPENDENCE
    Publication number: 20090176878
    Abstract: The invention encompasses a method for identifying subjects at risk for substance dependence by detecting the presence of polymorphism in the CHRNA5-CHRNA3-CHRNB4 gene cluster and the CHRNA4 gene. The invention also encompasses determining the response of a subject to a therapeutic substance, treating substance dependence in a subject, and evaluating the response of a subject to a substance cessation treatment.
    Type: Application
    Filed: October 6, 2008
    Publication date: July 9, 2009
    Applicant: WASHINGTON UNIVERSITY IN ST. LOUIS
    Inventors: Alison M. Goate, Laura J. Bierut, Jen C. Wang
  • Pathogenic tau mutations
    Patent number: 6475723
    Abstract: Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals containing a Tau pathology also are also described.
    Type: Grant
    Filed: April 30, 1999
    Date of Patent: November 5, 2002
    Assignees: Mayo Foundation for Medical Education and Research, Washington University, Erasmus Universiteit Rotterdam, The Victoria University of Manchester
    Inventors: Michael L. Hutton, Peter Heutink, Alison M. Goate, Stuart M. Brown
  • PATHOGENIC TAU MUTATIONS
    Publication number: 20020026651
    Abstract: Isolated nucleic acid molecules that include a tau gene sequence are described. The tau gene sequences have a mutation linked to a Tau pathology. Transgenic non-human mammals containing a Tau pathology also are also described.
    Type: Application
    Filed: April 30, 1999
    Publication date: February 28, 2002
    Inventors: Michael L. Hutton, Peter Heutink, Alison M. Goate, Stuart M. Brown
  • Method for elucidation and detection of polymorphisms, splice variants, and proximal coding mutations using intronic sequences of the alzheimer's S182 gene
    Patent number: 6083694
    Abstract: A method of detecting polymorphisms in the S182 gene by detecting mutations in the S182 gene using selected mismatched PCR primers comprising sequences derived from intronic sequences of the S182 gene is provided. A method of identifying an individual susceptible to late onset Alzheimer's Disease is also provided.
    Type: Grant
    Filed: October 25, 1996
    Date of Patent: July 4, 2000
    Assignees: University of South Florida, Washington University
    Inventors: John Hardy, Alison M. Goate
  • Mutant S182 genes
    Patent number: 5973133
    Abstract: The invention provides novel mutant S182 sequences, methods of diagnosing Alzheimer's disease using these novel mutant S182 genes, a model system for Alzheimer's disease comprising a mutant S182 gene, and methods of identifying mutations in genes homologous to the S182 gene.
    Type: Grant
    Filed: June 26, 1996
    Date of Patent: October 26, 1999
    Assignees: Washington University, University of South Flordia
    Inventors: John A. Hardy, Alison M. Goate