Abstract: The invention provides a compound of formula (0): or a pharmaceutically acceptable salt, N-oxide or tautomer thereof; wherein: n is 1 or 2; X is CH or N; Y is selected from CH and C—F; Z is selected from C—Rz and N; R1 is selected from: -(Alk1)t-Cyc1; wherein t is 0 or 1; Optionally substituted C1-6 acyclic hydrocarbon groups R2 is selected from hydrogen; halogen; and C1-8 hydrocarbon groups optionally substituted with one or more fluorine atoms; R3 is hydrogen or a group L1-R7; R4 is selected from hydrogen; methoxy; and optionally substituted C1-3 alkyl; and R4a is selected from hydrogen and a C1-3 alkyl group; wherein Rz, Alk1, Cyc1, L1 and R7 are defined herein; provided that the compound is other than 6-benzyl-3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and 3-{2-[(2-methylpyrimidin-4-yl)amino]pyridin-4-yl}-7,8-dihydro-1,6-naphthyridin-5(6H)-one and salts and tautomers thereof.

Abstract: A building framing system includes a floor portion or floor framing system, a wall portion or wall framing system, and a roof portion or roof framing system. Each framing system comprises a plurality of components. Each component defines a connection geometry for connecting one component to another. The connection geometries are such that mechanical or other similar fasteners are not required to hold the various components together; rather, the connection geometries connect the components and hold them in place with respect to one another. Further, the framing systems utilize pre-cut components such that the components of each framing system arrive onsite cut to a needed length and width and with the appropriate connection geometry.

Abstract: A building framing system includes a floor portion or floor framing system, a wall portion or wall framing system, and a roof portion or roof framing system. Each framing system comprises a plurality of components. Each component defines a connection geometry for connecting one component to another. The connection geometries are such that mechanical or other similar fasteners are not required to hold the various components together; rather, the connection geometries connect the components and hold them in place with respect to one another. Further, the framing systems utilize pre-cut components such that the components of each framing system arrive onsite cut to a needed length and width and with the appropriate connection geometry.

Abstract: A mild cleansing composition is disclosed. The composition includes a from about 3.5 percent to about 8.5 percent of an anionic surfactant; from about 0.1 percent to about 3 percent of a hydrophobically modified, crosslinked, anionic acrylic copolymer; and c) from about 1 percent to about 25 percent of a nonionic surfactant, wherein the weight ratio of component a) to component b) is about 1:1 to about 25:1. The composition is useful as shampoos, washes, baths, gels, lotions, creams, and the like.

Abstract: A mild cleansing composition is disclosed. The composition includes a from about 4 percent to about 8.5 percent of an anionic surfactant; from about 1 percent to about 30 percent of an amphoteric surfactant; and from about 0.1 percent to less than about 3 percent of a hydrophobically modified, crosslinked, anionic acrylic copolymer, wherein the weight ratio of anionic surfactant to hydrophobically modified, crosslinked, anionic acrylic copolymer is about 3:1 to about 40:1. The composition is useful as shampoos, washes, baths, gels, lotions, creams, and the like.

Abstract: A mild cleansing composition is disclosed. The composition includes a from about 1 percent to about 8 percent of an anionic surfactant; and from about 0.1 percent to about 3 percent of a hydrophobically modified, crosslinked, anionic acrylic copolymer, wherein the weight ratio of component a) to component b) is about 1:1 to about 20:1 and wherein the composition is substantially free of non-ionic surfactants. The compositions are useful as shampoos, washes, baths, gels, lotions, creams, and the like.

Abstract: A mild cleansing composition is disclosed. The composition includes a from about 4 percent to about 8.5 percent of an anionic surfactant; from about 1 percent to about 30 percent of an amphoteric surfactant; and from about 0.1 percent to less than about 3 percent of a hydrophobically modified, crosslinked, anionic acrylic copolymer, wherein the weight ratio of anionic surfactant to hydrophobically modified, crosslinked, anionic acrylic copolymer is about 3:1 to about 40:1. The composition is useful as shampoos, washes, baths, gels, lotions, creams, and the like.

Abstract: A cleansing composition including a) from about 0.1 percent to about 12.5 percent of an anionic surfactant; and b) from about 0.1 percent to about 8 percent of a hydrophobically modified, crosslinked, anionic acrylic copolymer, wherein the weight ratio of component a) to component b) is about 1:1 to about 40:1, and the composition is substantially free of amphoteric surfactants. The composition is useful as shampoos, washes, baths, gels, lotions, creams, and the like.

Abstract: A mild cleansing composition is disclosed. The composition includes a from about 1 percent to about 8 percent of an anionic surfactant; and from about 0.1 percent to about 3 percent of a hydrophobically modified, crosslinked, anionic acrylic copolymer, wherein the weight ratio of component a) to component b) is about 1:1 to about 20:1 and wherein the composition is substantially free of non-ionic surfactants. The compositions are useful as shampoos, washes, baths, gels, lotions, creams, and the like.

Abstract: A mild cleansing composition is disclosed. The composition includes a from about 3.5 percent to about 8.5 percent of an anionic surfactant; from about 0.1 percent to about 3 percent of a hydrophobically modified, crosslinked, anionic acrylic copolymer; and c) from about 1 percent to about 25 percent of a nonionic surfactant, wherein the weight ratio of component a) to component b) is about 1:1 to about 25:1. The composition is useful as shampoos, washes, baths, gels, lotions, creams, and the like.