Patents by Inventor Alison Velyian Todd
Alison Velyian Todd has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11802308Abstract: The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.Type: GrantFiled: June 25, 2020Date of Patent: October 31, 2023Assignee: SPEEDX PTY LTDInventors: Alison Velyian Todd, Elisa Mokany, Samantha Walker, Cortny Donald, Dina Lonergan, Lit Yeen Tan
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Publication number: 20230220463Abstract: The present invention provides oligonucleotides and methods for their use in the detection and/or differentiation of target nucleic acids. The oligonucleotides and methods find particular application in amplifying, detecting, and/or discriminating multiple targets simultaneously.Type: ApplicationFiled: June 30, 2020Publication date: July 13, 2023Inventors: Alison Velyian Todd, Nicole Jane Hasick, Ryung Rae Kim, Andrea Lee Lawrence
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Publication number: 20220056507Abstract: The present invention provides oligonucleotides and methods for their use in the detection and/or differentiation of target nucleic acids. The oligonucleotides and methods find particular application in amplifying, detecting, and/or discriminating multiple targets simultaneously.Type: ApplicationFiled: August 9, 2019Publication date: February 24, 2022Inventors: Nicole Jane HASICK, Ryung Rae KIM, Andrea Lee LAWRENCE, Alison Velyian TODD
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Publication number: 20210108261Abstract: The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.Type: ApplicationFiled: June 25, 2020Publication date: April 15, 2021Applicant: SPEEDX PTY LTDInventors: Alison Velyian Todd, Elisa Mokany, Samantha Walker, Cortny Donald, Dina Lonergan, Lit Yeen Tan
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Publication number: 20200299754Abstract: The present invention relates to compositions and methods for the detection of target molecules, and the amplification of detectable signals generated by detection assays. More specifically, the present invention relates to methods utilizing catalytic nucleic acid enzymes to generate and/or amplify a signal indicative of the presence of target molecules (e.g. nucleic acids and proteins), and compositions for use in the methods.Type: ApplicationFiled: April 11, 2018Publication date: September 24, 2020Applicant: SPEEDX PTY LTDInventors: Alison Velyian TODD, Nicole Jane HASICK
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Patent number: 10724080Abstract: The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.Type: GrantFiled: March 27, 2018Date of Patent: July 28, 2020Assignee: SPEEDX PTY LTDInventors: Alison Velyian Todd, Elisa Mokany, Samantha Walker, Cortny Donald, Dina Lonergan, Lit Yeen Tan
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Publication number: 20200199651Abstract: The present invention provides methods for quantitative data normalisation, and/or ascertaining levels of transcription in cells, organisms, viruses, and the like. The methods can be used in numerous applications including, but not limited to, determining transcriptional upregulation and downregulation, identifying transcriptional perturbation, determining viability/death, and assessing responses to treatment with agents (e.g. resistance or sensitivity to drugs).Type: ApplicationFiled: December 21, 2018Publication date: June 25, 2020Applicant: SpeeDx Pty LtdInventors: Alison Velyian Todd, Nicole Elizabeth Lima
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Patent number: 10273526Abstract: The invention relates to nucleic acid substrates for catalytic nucleic acid enzymes and methods utilizing the substrates.Type: GrantFiled: October 31, 2016Date of Patent: April 30, 2019Assignee: SPEEDX PTY LTDInventors: Alison Velyian Todd, Elisa Mokany, Evelyn Meiria Linardy, Dina Lonergan
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Publication number: 20190024160Abstract: The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.Type: ApplicationFiled: March 27, 2018Publication date: January 24, 2019Inventors: Alison Velyian Todd, Elisa Mokany, Samantha Walker, Cortny Donald, Dina Lonergan, Lit Yeen Tan
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Patent number: 9963738Abstract: The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.Type: GrantFiled: February 20, 2013Date of Patent: May 8, 2018Assignee: SPEEDX PTY LTDInventors: Alison Velyian Todd, Elisa Mokany, Samantha Walker, Cortny Donald, Dina Lonergan, Lit Yeen Tan
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Patent number: 9862990Abstract: The present invention relates to compositions and methods for the use of enzymes composed of nucleic acid and/or protein enzymes to generate and amplify a signal indicative of the presence of a target. More particularly, the invention relates to compositions comprising nucleic acid structures that serve as partial or complete enzyme substrates and methods for using these structures to facilitate detection of targets.Type: GrantFiled: November 21, 2011Date of Patent: January 9, 2018Assignee: SPEEDX PTY LTDInventors: Alison Velyian Todd, Evelyn Meiria Linardy, Elisa Mokany, Dina Lonergan
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Patent number: 9725757Abstract: The present invention relates to compositions and methods for the detection of target molecules, and the amplification of detectable signals generated by detection assays. More specifically, the present invention relates to methods utilizing catalytic nucleic acid enzymes to generate and/or amplify a signal indicative of the presence of target molecules (e.g. nucleic acids and proteins), and compositions for use in the methods.Type: GrantFiled: June 18, 2013Date of Patent: August 8, 2017Assignee: SPEEDX PTY LTDInventors: Simon Mark Bone, Alison Velyian Todd, Timothy Daniel Meehan
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Publication number: 20170114397Abstract: The invention relates to nucleic acid substrates for catalytic nucleic acid enzymes and methods utilising the substrates.Type: ApplicationFiled: October 31, 2016Publication date: April 27, 2017Inventors: Alison Velyian Todd, Elisa Mokany, Evelyn Meiria Linardy, Dina Lonergan
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Publication number: 20160348161Abstract: The present invention provides modified oligonucleotides and methods for their use in the detection of nucleic acids. The oligonucleotides and methods find particular application in amplifying and/or detecting areas of genetic variation in target nucleic acid sequences.Type: ApplicationFiled: February 20, 2013Publication date: December 1, 2016Applicant: SPEEDX PTY LTDInventors: Alison Velyian Todd, Elisa Mokany, Samantha Walker, Cortny Donald, Dina Lonergan, Lit Yeen Tan
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Patent number: 9506108Abstract: The invention relates to nucleic acid substrates for catalytic nucleic acid enzymes and methods utilizing the substrates.Type: GrantFiled: September 10, 2012Date of Patent: November 29, 2016Assignee: SPEEDX PTY LTDInventors: Alison Velyian Todd, Elisa Mokany, Evelyn Meiria Linardy, Dina Lonergan
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Publication number: 20160083785Abstract: The present invention relates to compositions and methods for the detection of target molecules, and the amplification of detectable signals generated by detection assays. More specifically, the present invention relates to methods utilizing catalytic nucleic acid enzymes to generate and/or amplify a signal indicative of the presence of target molecules (e.g. nucleic acids and proteins), and compositions for use in the methods.Type: ApplicationFiled: June 18, 2013Publication date: March 24, 2016Applicant: SpeeDx Pty LtdInventors: Simon Mark Bone, Alison Velyian Todd, Timothy Daniel Meehan
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Patent number: 9127311Abstract: The present invention relates to compositions and methods that allow the manipulation of the catalytic activity of multi-component nucleic acid complexes. Further, the invention provides methods which use these compositions and methods to create molecular sensors, molecular switches, and/or modulators or propagators of autocatalytic self-replicating cascades and other iterative processes. More particularly, the invention relates to compositions allowing self-assembly of active and inactive multicomponent nucleic acid complexes, methods of making such compositions, and methods for use.Type: GrantFiled: October 5, 2007Date of Patent: September 8, 2015Assignee: SpeeDx Pty LtdInventors: Alison Velyian Todd, Elisa Mokany, Donald John Birkett, Tram Bich Doan, Christopher Roland Reid
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Patent number: 8962238Abstract: The present invention relates to methods that utilize multi-component nucleic acid complex (MNA complex) cascades. The MNA complexes may have cleavage or ligase activity. Further, the invention provides cascades which may include one or more DNAzymes. The invention also provides methods which use these cascades for the identification, detection and quantification of targets.Type: GrantFiled: April 4, 2008Date of Patent: February 24, 2015Assignee: SpeedDx Pty LtdInventors: Alison Velyian Todd, Elisa Mokany, Tram Bich Doan, Paul Ean Young
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Publication number: 20150050656Abstract: The invention relates to nucleic acid substrates for catalytic nucleic acid enzymes and methods utilising the substrates.Type: ApplicationFiled: September 10, 2012Publication date: February 19, 2015Applicant: SPEEDX PTY LTDInventors: Alison Velyian Todd, Elisa Mokany, Evelyn Meiria Linardy, Dina Lonergan
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Patent number: 8945836Abstract: The present invention relates to Multicomponent Nucleic Acid Enzymes (MNAzymes) and methods for their use. MNAzymes comprise two or more oligonucleotide components which self-assemble in the presence of one or more MNAzyme assembly facilitator molecules to form a catalytically active structure. Compositions for making MNAzymes, and collections of MNAzymes are provided. Also provided are methods for using MNAzymes for the detection, identification and/or quantification of one or more targets. The methods can be practiced in solution-based assays or in assays where one or more reaction components are attached to a support structure. The methods allow for multiplexing the MNAzyme detection to detect multiple targets in a single reaction. Also provided are kits for making the compositions, and for practicing the methods provided herein.Type: GrantFiled: January 15, 2013Date of Patent: February 3, 2015Assignee: SpeeDx Pty LtdInventors: Alison Velyian Todd, Elisa Mokany