Abstract: The invention provides a compound for use as a protein kinase B inhibitor, the compound being a compound of the formula (I) or salts, solvates, tautomers or N-oxides thereof, wherein T is N or CR5; J1-J2 is N?C(R6), (R7)C?N, (R8)N—C(O), (R8)2C—C(O), N?N or (R7)C?C(R6); E is a monocyclic carbocyclic or heterocyclic group of 5 or 6 ring members, the heterocyclic group containing up to 3 heteroatoms selected from O, N and S; Q1 is a bond or a saturated C1-3 hydrocarbon linker group, one of the carbon atoms in the linker group being optionally be replaced by an oxygen or nitrogen atom, or an adjacent pair of carbon atoms may be replaced by CONRq or NRqCO where Rq is hydrogen or methyl, or Rq is a C1-4 alkylene chain linked to R1 or a carbon atom of Q1 to form a cyclic moiety; and wherein the carbon atoms of the linker group Q1 may optionally bear one or more substituents selected from fluorine and hydroxy; Q2 is a bond or a saturated hydrocarbon linker group containing from 1 to 3 carbon atoms, wherein one of the

Abstract: A linear actuator comprises rotary motion producing means (1,2,3,4,5); linear motion producing means (6,7,10,11,12) coupled with the rotary motion producing means for converting rotary motion to linear motion; a driven member (18) movable linearly by the linear motion providing means from a first position to a second position; and back-drive means (22) for returning the driven member to the first position. The arrangement is such that the linear motion producing means includes torque reaction means (13,15,16,17) which, in normal operation, is in an activated condition and provides a torque reaction path to enable the driven member to be moved from the first to the second position but which, in the event of a fault, is in a de-activated condition so that it no longer provides the torque reaction path and the back-drive means can move the driven member to the first position, without disengaging the rotary motion producing means from the linear motion producing means.

Abstract: A horseshoe (2) comprising a base portion (4) having a base surface (8), see FIG. 7, which, in use, is adjacent the hoof of a horse, an integral flange portion (6) which projects downwardly from the base portion (4), the flange portion (6) extending substantially along the entire length of the base portion (4), the flange portion (6) comprising, in cross section, first, second, third and fourth portions (30, 22, 18, 34), see FIG.