Patents by Inventor Alistair Lochead

Alistair Lochead has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • SUBSTITUTED N-OXIDE PYRAZINE DERIVATIVES
    Publication number: 20110136828
    Abstract: N-oxide pyrazine derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: R1. R2, R3, R4, and R5 are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I) and their use in therapeutics.
    Type: Application
    Filed: December 15, 2010
    Publication date: June 9, 2011
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Alistair LOCHEAD, Mourad SAADY, Philippe YAICHE
  • DERIVATIVES OF 5-PYRIDINYL-1-AZABICYCLO[3.2.1]OCTANE, PREPARATION METHOD THEREOF AND USE OF SAME IN THERAPEUTICS
    Publication number: 20110077264
    Abstract: The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
    Type: Application
    Filed: November 29, 2010
    Publication date: March 31, 2011
    Applicant: SANOFI-AVENTIS
    Inventors: Frederic GALLI, Odile LECLERC, Alistair LOCHEAD, Julien VACHE
  • SUBSTITUTED ARYLAMIDE DIAZEPINOPYRIMIDONE DERIVATIVES
    Publication number: 20110039835
    Abstract: The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4, R5 and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
    Type: Application
    Filed: July 27, 2010
    Publication date: February 17, 2011
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Aude FAYOL, Alistair LOCHEAD, Mourad SAADY, Julien VACHE, Philippe YAICHE
  • SUBSTITUTED HETEROARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES
    Publication number: 20110015176
    Abstract: The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4 and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
    Type: Application
    Filed: July 27, 2010
    Publication date: January 20, 2011
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Aude FAYOL, Alistair LOCHEAD, Mourad SAADY, Julien VACHE, Philippe YAICHE
  • SUBSTITUTED HETEROARYLAMIDE DIAZEPINOPYRIMIDONE DERIVATIVES
    Publication number: 20110015187
    Abstract: The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4, R5 and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
    Type: Application
    Filed: July 27, 2010
    Publication date: January 20, 2011
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Aude FAYOL, Alistair LOCHEAD, Mourad SAADY, Julien VACHE, Philippe YAICHE
  • SUBSTITUTED ARYLAMIDE OXAZEPINOPYRIMIDONE DERIVATIVES
    Publication number: 20110015177
    Abstract: The disclosure relates to a series pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: wherein: Y, Z, R1, R2, R3, R4 and n are as defined in the disclosure. Also disclosed are methods of preparing the compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
    Type: Application
    Filed: July 27, 2010
    Publication date: January 20, 2011
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Aude FAYOL, Alistair LOCHEAD, Mourad SAADY, Julien VACHE, Philippe YAICHE
  • Derivatives of 5-pyridinyl-1-azabicyclo[3.2.1]octane, preparation method thereof and use of same in therapeutics
    Patent number: 7863290
    Abstract: The invention relates to compounds having general formula (I), wherein R is as defined herein. The invention also relates to acid addition salt, a hydrate or a solvate of compounds of formula (I). The invention further relates to the method of preparing said compounds and to the use of same in therapeutics.
    Type: Grant
    Filed: February 11, 2008
    Date of Patent: January 4, 2011
    Assignee: sanofi-aventis
    Inventors: Frederic Galli, Odile LeClerc, Alistair Lochead, Julien Vache
  • Use of substituted 2-pyrimidinyl-6,7,8,9-tetrahydropyrimido[1,2-] pyrimidin-4-one and 7-pyrimidinyl-2,3-dihydroimidazo[1,2-] pyrimidin-5(1)one derivatives
    Patent number: 7781440
    Abstract: The invention relates to use of a pyrimidone derivative represented by formula (I) or a salt thereof as therapeutic agents: Wherein m, n, p, X, Y, R1, R2, R3, R4 R5, are as defined herein. The invention specifically relates to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3? or GSK3? and cdk5/p25, such as Alzheimer disease.
    Type: Grant
    Filed: May 14, 2008
    Date of Patent: August 24, 2010
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Thierry Gallet, Patrick Lardenois, Alistair Lochead, Severine Marguerie, Alain Nedelec, Mourad Saady, Franck Slowinski, Philippe Yaiche
  • ARYLAMIDE PYRIMIDONE COMPOUNDS
    Publication number: 20100087461
    Abstract: The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein X, Z, R1, R2, R3, R4, R5, R6, R7, n and m are as defined herein. Also disclosed herein are the methods of preparation of compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
    Type: Application
    Filed: October 27, 2009
    Publication date: April 8, 2010
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Alistair LOCHEAD, Mourad SAADY, Corinne VERONIQUE, Philippe YAICHE
  • HETEROARYLAMIDE PYRIMIDONE COMPOUNDS
    Publication number: 20100087449
    Abstract: The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein X, Z, R1, R2, R3, R4, R5, R6, R7, n and m are as defined herein. Also disclosed herein are the methods of preparation of compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
    Type: Application
    Filed: October 27, 2009
    Publication date: April 8, 2010
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Alistair Lochead, Mourad Saady, Corinne Veronique, Philippe Yaiche
  • ARYLAMIDE PYRIMIDONE DERIVATIVES
    Publication number: 20100087460
    Abstract: The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein X, Z, R1, R2, R3, R4, R5, R6, R7, n and m are as defined herein. Also disclosed herein are the methods of preparation of compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
    Type: Application
    Filed: October 27, 2009
    Publication date: April 8, 2010
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Nathalie CHEREZE, Thierry GALLET, Alistair LOCHEAD, Mourad SAADY, Corinne VERONIQUE, Philippe YAICHE
  • HETEROARYLAMIDE PYRIMIDONE DERIVATIVES
    Publication number: 20100081677
    Abstract: The present invention discloses a series of pyrimidone derivatives represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof: Wherein X, Z, R1, R2, R3, R4, R5, R6, R7, n and m are as defined herein. Also disclosed herein are the methods of preparation of compounds of formula (I), intermediates therefor and their utility in treating a variety of disease conditions.
    Type: Application
    Filed: October 27, 2009
    Publication date: April 1, 2010
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Nathalie CHEREZE, Thierry GALLET, Alistair LOCHEAD, Mourad SAADY, Corinne VERONIQUE, Philippe YAICHE
  • AZABICYCLOALKANE DERIVATIVES, PREPARATION THEREOF AND USE THEREOF IN THERAPY
    Publication number: 20100035916
    Abstract: The invention relates to compounds of the general formula (I): Wherein R, m, n and o are as defined herein. The invention also relates to a method for preparing the same and to the application in therapy.
    Type: Application
    Filed: August 4, 2009
    Publication date: February 11, 2010
    Applicant: SANOFI-AVENTIS
    Inventors: Omar BEN AYAD, Odile LECLERC, Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Julien VACHE
  • SUBSTITUTED HETEROARYL PYRIDOPYRIMIDONE DERIVATIVES
    Publication number: 20090306088
    Abstract: A pyrimidone derivative represented by formula (I) or a salt thereof, or a solvate thereof or a hydrate thereof are disclosed and claimed. Wherein m, n, o, Y, Z, R1, R2, R3, R4, R5 R6 and R7 are as described herein. Also disclosed are the salts of compounds of formula (I). The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Application
    Filed: June 18, 2009
    Publication date: December 10, 2009
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Aude FAYOL, Thierry GALLET, Alistair LOCHEAD, Mourad SAADY, Corinne VERONIQUE, Philippe YAICHE
  • SUBSTITUTED 8-PIPERIDINYL-2-PYRIDINYL-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE AND 8-PIPERIDINYL-2-PYRIMIDINYL-PYRIMIDO[1,2-a] PYRIMIDIN-6-ONE DERIVATIVES
    Publication number: 20090281121
    Abstract: The invention relates to a pyrimidone derivative represented by formula (I) or a salt thereof: Wherein X, Y, R1, R2, R3, R4, n, p, q, o and m are as described herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Application
    Filed: May 1, 2009
    Publication date: November 12, 2009
    Applicants: SANOFI-AVENTIS, MITSUBISHI TANABE PHARMA CORPORATION
    Inventors: Alistair LOCHEAD, Mourad SAADY, Franck SLOWINSKI, Philippe YAICHE
  • 1-[alkyl], 1-[(heteroaryl)alkyl] and 1-[(aryl)alkyl]-7-pyridinyl-imidazo[1,2-a]pyrimidin-5(1h)-one derivatives
    Patent number: 7608624
    Abstract: The invention relates to a method of treatment of a variety of neurodegenerative diseases such as Alzheimer disease using a imidazo[1,2-a]pyrimidone derivative represented by formula (I) or a salt thereof: Wherein X, R1, R2, and n are as defined herein.
    Type: Grant
    Filed: March 8, 2006
    Date of Patent: October 27, 2009
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation Tokyo
    Inventors: Alistair Lochead, Severine Marguerie, Mourad Saady, Philippe Yaiche
  • Derivatives of 1,4-diazabicyclo[3.2.1]octanecarboxamide, preparation method thereof and use of same in therapeutics
    Patent number: 7589201
    Abstract: The invention relates to a compound of formula (I): Wherein R1, X, P, Q, R and W are as defined herein. The invention also relates to the use of same in therapeutics.
    Type: Grant
    Filed: July 10, 2006
    Date of Patent: September 15, 2009
    Assignee: Sanofi-Aventis
    Inventors: Frederic Galli, Odile LeClerc, Alistair Lochead
  • Derivatives of 5-(pyridin-3-yl)-1-azabicyclo[3.2.1]octane, their preparation and their therapeutic application
    Patent number: 7585974
    Abstract: Compounds complying with the general formula in which R either represents a halogen atom or a phenyl group substituted by one or more groups chosen from halogen atoms and (C1-C6)alkyl, (C1-C6)alkoxy, nitro, amino, trifluoromethyl, cyano, hydroxy, acetyl or methylenedioxy groups, or represents a pyridinyl group, a thienyl group, an indolyl group, or a pyrimidinyl group optionally substituted by one or more (C1-C6)alkoxy groups, where, of the two carbon-carbon bonds represented by , one is single and the other may be single or double. The compounds of this invention are useful as therapeutic agents.
    Type: Grant
    Filed: April 5, 2007
    Date of Patent: September 8, 2009
    Assignee: Sanofi-Aventis
    Inventors: Frederic Galli, Odile LeClerc, Alistair Lochead, Alain Nedelec
  • 2-pyridinyl-6,7,8,9-tetrahydropyrimido[1,2-a] pyrimidin-4-one and 7-pyridinyl-2,3-dihydroimidazo[1,2-a] pyrimidin-5(1)one derivatives
    Patent number: 7566720
    Abstract: The invention relates to therapeutic uses of a pyrimidone derivative represented by formula (I) or a salt thereof: Wherein X, Y, R1, R2, m and n are as defined herein. Specifically, a medicament comprising the said derivative or a salt thereof as an active ingredient is used for preventive and/or therapeutic treatment of a neurodegenerative diseases caused by abnormal activity of GSK3? such as Alzheimer's disease.
    Type: Grant
    Filed: August 20, 2007
    Date of Patent: July 28, 2009
    Assignees: Sanofi-Aventis, MItsubishi Pharma Corporation
    Inventors: Antonio Almario Garcia, Thierry Gallet, Adrien Tak Li, Alistair Lochead, Severine Marguerie, Alain Nedelec, Mourad Saady, Philippe Yaiche
  • Substituted 8?-pyri(MI)dinyl-dihydrospiro-[cycloalkylamine]-pyrimido[1,2-]pyrimidin-6-one derivatives
    Patent number: 7547705
    Abstract: The invention relates to a dihydrospiro-[cycloalkylamine]-pyrimidone derivative represented by formula (I) or a salt thereof: wherein: X, Y, R1, R2, R3, R4, o, m, n, p and q are as defined herein. The invention relates also to a medicament comprising the said derivative or a salt thereof as an active ingredient which is used for preventive and/or therapeutic treatment of a neurodegenerative disease caused by abnormal activity of GSK3?, such as Alzheimer disease.
    Type: Grant
    Filed: October 3, 2007
    Date of Patent: June 16, 2009
    Assignees: Sanofi-Aventis, Mitsubishi Pharma Corporation
    Inventors: Nathalie Chereze, Alistair Lochead, Mourad Saady, Franck Slowinski, Philippe Yaiche