Patents by Inventor Alja{hacek over (z)} Kajtna

Alja{hacek over (z)} Kajtna has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process to convert technical ascomycin into purified pimecrolimus
    Patent number: 10975097
    Abstract: The present disclosure is directed to an improved process to convert crude ascomycin to purified pimecrolimus. Crude ascomycin is chlorinated with triphenylphosphine and N-chlorosuccinimide (NCS) to yield crude pimecrolimus, which is then purified further by HPLC and subsequent crystallization. The processes of the present disclosure enable the removal of close homologs of pimecrolimus by high-pressure liquid chromatography without prior purification of the ascomycin starting material. This improvement may make the conversion of ascomycin to pimecrolimus industrially applicable and less expensive.
    Type: Grant
    Filed: May 2, 2018
    Date of Patent: April 13, 2021
    Inventors: Borut Gabriel, Alja{hacek over (z)} Kajtna, Ajna Lukic, Dominic De Souza, Werner Hasselwander