Abstract: A method of treating a bacterial infection including bacteria that have become resistant to an antibiotic in a subject in need thereof is provided. The method includes administering to the subject a safe and therapeutically effective amount of the antibiotic and a reviving agent selected from the group consisting of glass-ceramic particles, silver ions, and combinations thereof. The reviving agent restores antibiotic activity to the antibiotic against the bacteria.

Abstract: A bioactive scaffold is provided. The bioactive scaffold includes an interconnected web of struts composed of a glass-ceramic material, the web of struts being printed as a three-dimensional structure from a filament composition having a bimodal distribution of glass-ceramic microparticles, wherein the bioactive scaffold has a porosity defined by spaces between struts of greater than or equal to about 40% to less than or equal to about 80% and an average pore size of greater than or equal to about 200 ?m to less than or equal to about 400 ?m. Methods of making the bioactive scaffold and treating bone defects using the bioactive scaffolds are also provided.

Abstract: A filled and 3D printable filament is provided. In another aspect, a flexible filament comprises polyisoprene, a polymer and a filler. An aspect of a filament or fiber apparatus includes a flexible filament composition coiled around a spool, the filament or fiber composition further including polyisoprene, a polymer, and a ceramic or metallic filler. Another aspect of a filament or fiber apparatus includes a flexible filament composition further including an isoprene rubber, a polymer, a sintering aid additive, and a ceramic or metallic filler.

Abstract: A method of treating a bacterial infection including bacteria that have become resistant to an antibiotic in a subject in need thereof is provided. The method includes administering to the subject a safe and therapeutically effective amount of the antibiotic and a reviving agent selected from the group consisting of glass-ceramic particles, silver ions, and combinations thereof. The reviving agent restores antibiotic activity to the antibiotic against the bacteria.