Abstract: A new anti-herpetic composition is proposed which comprises a virion preparation containing herpes simplex viruses of serotypes 1 and 2 inactivated by formalin or ?-irradiation; the composition further comprises a hi-tech immunomodulator Polyoxidonium, and also amino acids valine and lysine, as well as a combination consisting of at least two amino acids selected from the group: phenylalanine, leucine, alanine, threonine, histidine, arginine, methionine, and can also comprise isoleucine, which is able to stimulate the formation of anti-herpetic peptides at the cell level. The composition can be formulated into various pharmaceutical forms, and owing to its properties it can be used not only in the case of acute, but also in the case of chronic herpetic pathology.